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上海中医药大学 [2]
南华大学 [1]
北京大学 [1]
中南大学 [1]
上海大学 [1]
湖南农业大学 [1]
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期刊论文 [9]
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2015 [2]
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2011 [2]
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Huangqi (astragalus) decoction ameliorates diabetic nephropathy via IRS1-PI3K-GLUT signaling pathway
期刊论文
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2018, 卷号: 10, 期号: 8
作者:
Chen, Xia
;
Wang, Hao
;
Jiang, Minqian
;
Zhao, Jie
;
Fan, Chunling
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/12/05
Astragalus
insulin receptor substrate1
phosphatidylinositol 3 kinase
glucose transporter
db/db mice
diabetic nephropathy
Huangqi (astragalus) decoction ameliorates diabetic nephropathy via IRS1-PI3K-GLUT signaling pathway
期刊论文
American journal of translational research, 2018, 卷号: 10, 页码: 2491-2501
作者:
Chen Xia[1]
;
Wang Hao[2]
;
Jiang Minqian[3]
;
Zhao Jie[4]
;
Fan Chunling[5]
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/04/22
Astragalus
db/db mice
diabetic nephropathy
glucose transporter
insulin receptor substrate1
phosphatidylinositol 3 kinase
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
Long-term effect of early postnatal overnutrition on insulin resistance and serum fatty acid profiles in male rats
期刊论文
LIPIDS IN HEALTH AND DISEASE, 2015, 卷号: 14
作者:
Bei, Fei
;
Jia, Jia
;
Jia, Yi-Qun
;
Sun, Jian-Hua
;
Liang, Fei
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
Early overnutrition
Insulin resistance
Insulin receptor substrate 1
Glucose transporter 4
Fatty acid
Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance
期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2015, 卷号: 15, 期号: 4, 页码: 423-432
作者:
Li, Shuaizhang
;
Zhang, Wen
;
Yin, Xuejiao
;
Xing, Shilai
;
Xie, Heidi Qunhui
收藏
  |  
浏览/下载:182/0
  |  
提交时间:2016/03/10
ATP-binding cassette (ABC) transporter
cancer
inhibitors
multi-drug resistance
substrate
Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice
期刊论文
Journal of Hepatology, 2014, 卷号: 60, 期号: 5, 页码: 1046-1054
作者:
Zhu, Li-Hua
;
Wang, Aibing
;
Luo, Pengcheng
;
Wang, Xinan
;
Jiang, Ding-Sheng
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/23
IR
insulin resistance
WT
wild type
KO
knockout
TG
transgenic
NTG
non-transgenic
NC
normal chow
HFD
high-fat diet
PPARα
peroxisome proliferator-activated receptor alpha
ECM
extracellular matrix
NL
normal liver
NAFLD
non-alcoholic fatty liver disease
H&E
hematoxylin and eosin
ALT
alanine transaminase
AST
aspartate transaminase
ALP
alkaline phosphatase
HMGCR
3-hydroxy-3-methyl-glutaryl-CoA reductase
LDL
low density lipoprotein
HDL
high density lipoprotein
LDLR
low-density lipoprotein receptor
GPAT
glycerol-3-phosphate acyltransferase
DGAT
diglyceride acyltransferase
FFA
free fatty acid
SREBP1c
sterol response element binding protein 1c
ACC
acetyl-CoA carboxylase
FAS
fatty acid synthase
SCD
stearoyl-CoA desaturase
LXR-α
liver X receptor-α
ARG-1
arginase-1
ABCA
ATP-binding cassette transporter A
ABCG
ATP-binding cassette transporter G
CYP7A1
cytochrome P450, family 7, subfamily A, polypeptide 1
AMPK
AMP-activated protein kinase
IL
interleukin
TNF-α
tumor necrosis factor alpha
MCP-1
monocyte chemoattractant protein 1
MRC1
mannose receptor, C type 1
MGL
macrophage galactose-type C-type lectin
JNK
Jun N-terminal kinase
FBG
fasting glucose
HOMA-IR
homeostasis model assessment of insulin resistance
GTT
glucose tolerance test
ITT
intraperitoneal insulin tolerance test
Fins
fasting insulin
shRNA
short hairpin RNA
GFP
green fluorescent protein
IRS
insulin receptor substrate
Akt
protein kinase B
HSL
hormone sensitive lipase
ATGL
adipose triacylglycerol lipase
ACOX
acyl-coenzyme A oxidase
CPT-1α
carnitine palmitoyltransferase-1-α
LCAD
long-chain acyl-CoA dehydrogenase
MCAD
medium-chain acyl-CoA dehydrogenase
UCP
uncoupling protein
FGF21
fibroblast growth factor
PPRE
peroxisome proliferators response element
AUC
area under the curve
IKKβ
inhibitor of nuclear factor kappa B kinase beta subunit
Spondin 2
Fatty liver
Insulin resistance
PPARα
Apelin and its receptor APJ in cardiovascular diseases
期刊论文
Clinica chimica acta, international journal of clinical chemistry, 2014, 卷号: 428, 页码: 1-8
作者:
Yu, Xiao-Hua*
;
Tang, Zhi-Bin
;
Liu, Li-Jing
;
Qian, Hong
;
Tang, Shi-Lin
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/27
ABCA1
ACAT1
APJ
ATP-binding cassette transporter A1
Ang II
Ang-1
Apelin
Atherosclerosis
BMP
BNP
CAD
COX-2
FGF2
GSK
HDAC
HIF-1alpha
Heart failure
Hypertension
ICAM-1
IRS1
JNK
MCP-1
MEF2
MIRI
NO
PAH
PDGF-BB
PGE2
PI3K
PKB
PKC
PPAR response elements
PPREs
TGF-beta
TNF-alpha
VCAM-1
VEGFA
VSMC
acyl coenzyme A:cholesterol acyltransferase-1
angiopoietin-1
angiotensin II
apo E
apolipoprotein E
bone morphogenic protein
brain natriuretic peptide
c-Jun N-terminal kinase
coronary heart disease
cyclooxygenase-2
fibroblast growth factor 2
glycogen synthase kinase
histone deacetylase
hypoxia-inducible factor 1alpha
insulin receptor substrate 1
intercellular adhesion molecule-1
monocyte chemoattractant protein-1
myocardial ischemia-reperfusion injury
myocyte enhancer factor 2
nitric oxide
phosphatidylinositol 3-kinase
platelet-derived growth factor-BB
prostaglandin E2
protein kinase B
protein kinase C
pulmonary arterial hypertension
transforming growth factor-beta
tumor necrosis factor-alpha
vascular cell adhesion molecule-1
vascular endothelial growth factor type A
vascular smooth muscle cell
TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates
期刊论文
science china life sciences, 2011
Zhao Min
;
Chen YanMing
;
Qu DaCheng
;
Qu Hong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/11/11
transporter substrate
biological database
compound classification
compound metabolic network
RELATIONAL DATABASE
RESOURCE
KEGG
PHARMACOGENOMICS
INFORMATION
UPDATE
TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates
期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2011, 卷号: 54, 期号: 1, 页码: 60-64
作者:
Zhao Min
;
Chen YanMing
;
Qu DaCheng
;
Qu Hong
;
quh@mail.cbi.pku.edu.cn
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2013/11/27
Transporter Substrate
Biological Database
Compound Classification
Compound Metabolic Network
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