TSdb: A database of transporter substrates linking metabolic pathways   and transporter systems on a genome scale via their shared substrates

doi:10.1007/s11427-010-4125-y

CORC > 北京大学 > 生命科学学院

	TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates
	Zhao Min ; Chen YanMing ; Qu DaCheng ; Qu Hong
刊名	science china life sciences
	2011
关键词	transporter substrate biological database compound classification compound metabolic network RELATIONAL DATABASE RESOURCE KEGG PHARMACOGENOMICS INFORMATION UPDATE
DOI	10.1007/s11427-010-4125-y
英文摘要	TSdb (http://tsdb.cbi.pku.edu.cn) is the first manually curated central repository that stores formatted information on the substrates of transporters. In total, 37608 transporters with 15075 substrates from 884 organisms were curated from UniProt functional annotation. A unique feature of TSdb is that all the substrates are mapped to identifiers from the KEGG Ligand compound database. Thus, TSdb links current metabolic pathway schema with compound transporter systems via the shared compounds in the pathways. Furthermore, all the transporter substrates in TSdb are classified according to their biochemical properties, biological roles and subcellular localizations. In addition to the functional annotation of transporters, extensive compound annotation that includes inhibitor information from the KEGG Ligand and BRENDA databases has been integrated, making TSdb a useful source for the discovery of potential inhibitory mechanisms linking transporter substrates and metabolic enzymes. User-friendly web interfaces are designed for easy access, query and download of the data. Text and BLAST searches against all transporters in the database are provided. We will regularly update the substrate data with evidence from new publications.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000286470400009&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biology; SCI(E); PubMed; 20; ARTICLE; 1; 60-64; 54
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/194595]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhao Min,Chen YanMing,Qu DaCheng,et al. TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates[J]. science china life sciences,2011.
APA	Zhao Min,Chen YanMing,Qu DaCheng,&Qu Hong.(2011).TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates.science china life sciences.
MLA	Zhao Min,et al."TSdb: A database of transporter substrates linking metabolic pathways and transporter systems on a genome scale via their shared substrates".science china life sciences (2011).