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	Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance
	Li, Shuaizhang; Zhang, Wen; Yin, Xuejiao; Xing, Shilai; Xie, Heidi Qunhui; Cao, Zhengyu; Zhao, Bin
刊名	ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
	2015
卷号	15期号:4页码:423-432
关键词	ATP-binding cassette (ABC) transporter cancer inhibitors multi-drug resistance substrate
英文摘要	The ABC (ATP-binding cassette) transporter is one of the largest and most ancient protein families with members functioning from protozoa to human. The resistance of cancer and tumor cells to anticancer drugs is due to the over-expression of some ABC transporters, which may finally lead to chemotherapy failure. The mouse ABC transporters are classified into seven subfamilies by phylogenetic analysis. The mouse ABC transporter gene, alias, chromosomal location and function have been determined. Within the ABC super-family, the MDR transporters (Abcb1, Abcc1, Abcg2) in mouse models have been proved to be valuable to investigate the biochemistry and physiological functions. This review concentrates on the multidrug resistance of mouse ABC transporters in cancer and tumor cells.
研究领域[WOS]	Oncology ; Chemistry, Medicinal
WOS记录号	WOS:000353913200002
公开日期	2016-03-15
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/32624]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
推荐引用方式 GB/T 7714	Li, Shuaizhang,Zhang, Wen,Yin, Xuejiao,et al. Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance[J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,2015,15(4):423-432.
APA	Li, Shuaizhang.,Zhang, Wen.,Yin, Xuejiao.,Xing, Shilai.,Xie, Heidi Qunhui.,...&Zhao, Bin.(2015).Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance.ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY,15(4),423-432.
MLA	Li, Shuaizhang,et al."Mouse ATP-Binding Cassette (ABC) Transporters Conferring Multi-Drug Resistance".ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY 15.4(2015):423-432.

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