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	Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
	Yang, Xin; Xu, Zhipeng; Zhang, Chunlan; Cai, Zixin; Zhang, Jingjing*
刊名	Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
	2017
卷号	1863期号:8页码:1984-1990
关键词	A1c glycated hemoglobin AACE American Association of Clinical Endocrinologists ACC acetyl-CoA carboxylase ADA American Diabetes Association Akt/PKB tyrosine kinase/protein kinase B AMP adenosine monophosphate AMPK adenosine monophosphate-activated protein Ang II angiotensin II ATP adenosine triphosphate BAT brown adipose tissue CHOP CEBP-homologous protein CEBP CCAAT enhancer binding protein CoA coenzyme A DPP Diabetes Prevention Program EASD European Association for the Study of Diabetes eNOS endothelial nitric oxide synthase ER endoplasmic reticulum FDA Food and Drug Administration FFA free fatty acid FOXO1 forkhead box protein O1 G6P glucose 6-phosphate GDM gestational diabetes mellitus GIPR glucose-dependent insulinotropic polypeptide receptor GLP-1R glucagon-like peptide-1 receptor GLUT1 glucose transporter-1 GLUT4 glucose transporter type 4 GLUTs glucose transporters G6P glucose 6-phosphate, glucose transporter-1 GPR40 G protein-coupled receptor 40 HbA1c hemoglobin A1c HGP hepatic glucose production HSL hormone sensitive lipase IL-6 interleukin 6 INS-1 insulinoma cells in rat IR insulin resistance IRS-1 insulin receptor substrate 1 JNK c-Jun. N-terminal kinase Kir6.2 inwardly rectifying potassium/kalium channel LDs lipid droplets LDL low density lipoprotein LV left ventricular MIN6 cells mouse insulinoma cells MAPK mitogen-activated protein kinases mPTP mitochondrial permeability transition pore opening mTOR mammalian target of rapamycin NADPH nicotinamide adenine dinucleotide phosphate NF-kappaB nuclear factors-kappa B NIT-1 cells insulinoma cells p70S6K p70 ribosomal S6 kinase PA palmitic acid NOS NADPH oxidase p38 MAPK p38 mitogen-activated protein kinase PA palmitic acid PCOS polycystic ovary syndrome PGC-1α peroxisome proliferator-activated receptor-g coactivator-1α PI3K phosphatidylinositol 3-kinase PKB protein kinase B PKC protein kinase C PPARα peroxisome-proliferator activated receptor α PTP permeability transition pore RCT randomized controlled trial RISK reperfusion injury salvage kinase ROS reactive oxygen species SERCA2 reticulum sarcoplasmic Ca2 +-ATPase RISK reperfusion injury salvage kinase Smad3 mothers against decapentaplegic homolog 3 SRC-2 steroid receptor coactivator 2 T1DM Type 1 diabetes mellitus T2DM Type 2 diabetes mellitus TGFβ1 transforming growth factor β1 TLR4 Toll-like receptor TNF-α tumor necrosis factor α TR4 testicular receptor 4 UKPDS United Kingdom Prospective Diabetes Study VLDL very low density lipoprotein Metformin Pancreatic β Cells Heart failure Insulin sensitizer
ISSN号	0925-4439
DOI	10.1016/j.bbadis.2016.09.019
URL标识	查看原文
WOS记录号	WOS:000405048200013;PMID:27702625
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/3331332
专题	中南大学
作者单位	1.[Zhang, Chunlan 2.Zhang, Jingjing 3.Yang, Xin 4.Xu, Zhipeng 5.Cai, Zixin] Cent S Univ, Dept Endocrinol & Metab, Changsha 410011, Hunan, Peoples R China.
推荐引用方式 GB/T 7714	Yang, Xin,Xu, Zhipeng,Zhang, Chunlan,et al. Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells[J]. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,2017,1863(8):1984-1990.
APA	Yang, Xin,Xu, Zhipeng,Zhang, Chunlan,Cai, Zixin,&Zhang, Jingjing*.(2017).Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells.Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,1863(8),1984-1990.
MLA	Yang, Xin,et al."Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells".Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863.8(2017):1984-1990.

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