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期刊论文 [9]
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Visualization of Alzheimer's Disease Related alpha-/beta-/gamma-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer
期刊论文
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 卷号: 11, 期号: 1, 页码: 431
作者:
Wang, Xin
;
Pei, Gang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/04/28
Amyloid Precursor Protein
Beta-secretase
App
Site
Cleavage
Adam10
Bace1
Localization
Dimerization
Endocytosis
Alzheimer's disease-associated mutations increase amyloid precursor protein resistance to gamma-secretase cleavage and the A beta 42/A beta 40 ratio
期刊论文
CELL DISCOVERY, 2016, 卷号: 2
作者:
Xu, Ting-Hai
;
Yan, Yan
;
Kang, Yanyong
;
Jiang, Yi
;
Melcher, Karsten
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/01/08
Alzheimer's disease
C99
gamma-secretase
familial Alzheimer disease (FAD)-linked mutations
epsilon-cleavage assay
SCG10 promotes non-amyloidogenic processing of amyloid precursor protein by facilitating its trafficking to the cell surface
期刊论文
human molecular genetics, 2013
Wang, Jingjing
;
Shan, Chunyan
;
Cao, Wenyuan
;
Zhang, Chen
;
Teng, Junlin
;
Chen, Jianguo
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2015/11/13
MICROTUBULE-DESTABILIZING ACTIVITY
GROWTH-ASSOCIATED PROTEIN
BETA-SECRETASE CLEAVAGE
ALZHEIMERS-DISEASE
AXONAL-TRANSPORT
GAMMA-SECRETASE
MOUSE MODEL
RAT-BRAIN
IN-VITRO
STATHMIN
Divalent cation tolerance protein binds to beta-secretase and inhibits the processing of amyloid precursor protein
期刊论文
http://dx.doi.org/10.3969/j.issn.1673-5374.2013.11.004, 2013
Liu, Runzhong
;
Hou, Haibo
;
Yi, Xuelian
;
Wu, Shanwen
;
Zeng, Huan
;
刘润忠
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2015/07/22
GATED SODIUM-CHANNELS
ALZHEIMERS-DISEASE
PEPTIDE GENERATION
TRANSGENIC MICE
MEMORY DEFICITS
GAMMA-SECRETASE
BACE1
ACETYLCHOLINESTERASE
CLEAVAGE
BRAIN
Hippocampal metabolomics using ultrahigh-resolution mass spectrometry reveals neuroinflammation from Alzheimer's disease in CRND8 mice
期刊论文
http://dx.doi.org/10.1007/s00216-013-6825-1, 2013
Lin, Shuhai
;
Liu, Hongde
;
Kanawati, Basem
;
Liu, Liangfeng
;
Dong, Jiyang
;
Li, Min
;
Huang, Jiandong
;
Schmitt-Kopplin, Philippe
;
Cai, Zongwei
;
董继扬
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2015/07/22
TRANSGENIC MOUSE MODEL
SWEDISH APP MUTATION
AMYLOID DEPOSITION
METABOLITE IDENTIFICATION
SECRETASE CLEAVAGE
FT-ICR
INFLAMMATION
DEFICITS
gamma-Secretase-mediated growth hormone receptor proteolysis: Mapping of the intramembranous cleavage site
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 卷号: 408, 期号: 3, 页码: 432-436
作者:
Wang, Xiangdong
;
Cowan, Jon W.
;
Gerhart, Mary
;
Zelickson, Blake R.
;
Jiang, Jing
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  |  
浏览/下载:2/0
  |  
提交时间:2019/12/23
GH receptor
gamma-Secretase
Cleavage site
Proteolysis
Hypoxia-inducible factor 1 alpha (HIF-1 alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation
期刊论文
http://dx.doi.org/10.1074/jbc.M608856200, 2007
Zhang, X.
;
Zhou, K.
;
Wang, R. S.
;
Cui, J. K.
;
Lipton, S. A.
;
Liao, F. F.
;
Xu, H. X.
;
Zhang, Y. W.
;
张云武
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2013/12/12
HUMAN NEUROBLASTOMA SH-SY5Y
ALPHA-SECRETASE CLEAVAGE
PRECURSOR PROTEIN
ALZHEIMERS-DISEASE
TRANSCRIPTIONAL REGULATION
CEREBRAL-ISCHEMIA
INDUCIBLE FACTOR-1-ALPHA
GENE-EXPRESSION
MESSENGER-RNA
APP
Recent progress in the study of intracellular toxicity of amyloid beta peptide in Alzheimer's disease
期刊论文
progress in natural science, 2007
Zhang Yan
;
Yu Longchuan
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2015/11/13
Alzheimer&apos
amyloid beta peptide
neruonal loss
APOPTOTIC CELL-DEATH
A-BETA
SECRETASE CLEAVAGE
HUMAN NEURONS
NEUROTROPHIN RECEPTOR
PRECURSOR PROTEIN
TRANSGENIC MICE
CYTOTOXICITY
ACCUMULATION
EXPRESSION
s disease
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