Recent progress in the study of intracellular toxicity of amyloid beta   peptide in Alzheimer&apos;s disease

doi:10.1080/10020070612331343253

CORC > 北京大学 > 生命科学学院

	Recent progress in the study of intracellular toxicity of amyloid beta peptide in Alzheimer's disease
	Zhang Yan ; Yu Longchuan
刊名	progress in natural science
	2007
关键词	Alzheimer&apos amyloid beta peptide neruonal loss APOPTOTIC CELL-DEATH A-BETA SECRETASE CLEAVAGE HUMAN NEURONS NEUROTROPHIN RECEPTOR PRECURSOR PROTEIN TRANSGENIC MICE CYTOTOXICITY ACCUMULATION EXPRESSION s disease
DOI	10.1080/10020070612331343253
英文摘要	Amyloid beta (A beta) deposition is one of the major pathological markers of Alzheimer's disease (AD). Extracellular A beta toxicity has been studied for a long time in AD research field. However, controversial data show that extracellular A(3 load does not correlate with the dementia levels of AD patients and extracellular A(3 only induces significant cell death at non-physiological high concentrations. With the evolvement of A beta hypothesis, considerable attention has been devoted to the study of intracellular A beta toxicity recently. Intracellular A beta induces dramatic cell loss in AD transgenic models and in human primary neurons (at pM concentrations) through p53, Bax and caspase-6 pathways. Here, we review the generation, toxicity and possible pathways of intracellular A beta toxicity, and discuss the implication and current knowledge of intracellular A beta in neuronal cell loss in neurodegenerative diseases.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000246193900001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Materials Science, Multidisciplinary; Multidisciplinary Sciences; SCI(E); EI; 0; REVIEW; 3; 233-236; 17
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/320265]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang Yan,Yu Longchuan. Recent progress in the study of intracellular toxicity of amyloid beta peptide in Alzheimer's disease[J]. progress in natural science,2007.
APA	Zhang Yan,&Yu Longchuan.(2007).Recent progress in the study of intracellular toxicity of amyloid beta peptide in Alzheimer's disease.progress in natural science.
MLA	Zhang Yan,et al."Recent progress in the study of intracellular toxicity of amyloid beta peptide in Alzheimer's disease".progress in natural science (2007).