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上海药物研究所 [8]
北京大学 [1]
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海洋研究所 [1]
中南大学 [1]
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期刊论文 [16]
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2024 [1]
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2019 [2]
2017 [2]
2016 [3]
2015 [1]
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JC-010a, a novel selective SHP2 allosteric inhibitor, overcomes RTK/non-RTK-mediated drug resistance in multiple oncogene-addicted cancers
期刊论文
CANCER LETTERS, 2024, 卷号: 582, 页码: 15
作者:
Lu, Xuxiu
;
Yu, Rilei
;
Li, Zhen
;
Yang, Mengke
;
Dai, Jiajia
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/04/07
Acquired resistance
Cancer
NSCLC
JC-010a
SHP2
Profiling Receptor Tyrosine Kinase Fusions in Chinese Breast Cancers
期刊论文
FRONTIERS IN ONCOLOGY, 2021, 卷号: 11
作者:
Tao, Zhonghua
;
Liu, Jianxia
;
Li, Ting
;
Xu, Hong
;
Chen, Kai
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/01/10
receptor tyrosine kinase
gene fusion
genomic rearrangments
breast cancer
next-generation sequencing
Activation and function of receptor tyrosine kinases in human clear cell renal cell carcinomas
期刊论文
BMC CANCER, 2019, 卷号: 19, 期号: 1, 页码: 13
作者:
Zhang, Qing
;
Liu, Jian-He
;
Liu, Jing-Li
;
Qi, Chun-Ting
;
Yan, Lei
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2020/07/01
Receptor tyrosine kinases (RTKs)
Activation and function
Clear cell renal cell carcinomas (ccRCCs)
Targeted therapy
PDGFR beta
Stroma cells
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer
期刊论文
NATURE COMMUNICATIONS, 2019, 卷号: 10, 页码: 15
作者:
Jin, Nan
;
Bi, Aiwei
;
Lan, Xiaojing
;
Xu, Jun
;
Wang, Xiaomin
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2020/07/01
Concomitant inhibition of receptor tyrosine kinases and downstream AKT synergistically inhibited growth of KRAS/BRAF mutant colorectal cancer cells
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 3, 页码: 5003-5015
作者:
Song, Qiaoling
;
Sun, Xiaoxiao
;
Guo, Hui
;
Yu, Qiang
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
receptor tyrosine kinases
AKT
colorectal cancer
drug combination
RAS/RAF
Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance
期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 135, 页码: 34-48
作者:
Zha, Gao-Feng
;
Qin, Hua-Li*
;
Youssif, Bahaa G. M.
;
Amjad, Muhammad Wahab
;
Raja, Maria Abdul Ghafoor
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/04
Epidermal growth factor receptor (EGFR)
BRAF
Focal adhesion kinase (FAK)
Tubulin polymerization
Cancer cell lines
MDR
multidrug resistance
EGFR
epidermal growth factor receptor
EMEA
European Medicines Evaluation Agency
FDA
US Food and Drug Administration
NSCLC
non-small cell lung
FAK
focal adhesion kinase
RTK
receptor tyrosine kinases
MAPK
mitogen-activated protein kinase
ABC
ATP-binding cassette
NF-kB
NF-kappaB
FERM
Four-point-one, ezrin, radixin, moesin
TMP
Ligustrazine or tetramethylpyrazine
Adr
Adriamycin
DRS
death receptors
TFN
tumor necrosis factor
PI
propidium iodide
TKIs
tyrosine kinase inhibitors
FAR
fluorescence activity ratio
HRMS
high resolution mass spectra
TLC
thin layer chromatography
UV
ultraviolet
DMEM
Dulbecco's modified Eagle's medium
DMSO
dimethyl sulfoxide
IBX
2-iodoxybenzoic acid
Receptor Tyrosine Kinase Phosphorylation Pattern-Based Multidrug Combination Is an Effective Approach for Personalized Cancer Treatment
期刊论文
MOLECULAR CANCER THERAPEUTICS, 2016, 卷号: 15, 期号: 10, 页码: 2508-2520
作者:
Sun, Xiaoxiao
;
Song, Qiaoling
;
He, Li
;
Yan, Lei
;
Liu, Jingli
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
Suppression of Spry4 enhances cancer stem cell properties of human MDA-MB-231 breast carcinoma cells
期刊论文
CANCER CELL INTERNATIONAL, 2016, 卷号: 16
作者:
Hua, Shucheng
;
Jing, Hongyu
;
Liaw, Lucy
;
Friesel, Robert
;
Vary, Calvin
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/05
Sprouty4 (Spry4)
Cancer stem cells
Beta3-integrin (CD61)
CD133
Receptor tyrosine kinases (RTK)
Co-expression modules of NF1, PTEN and sprouty enable distinction of adult diffuse gliomas according to pathway activities of receptor tyrosine kinases
期刊论文
ONCOTARGET, 2016
Zhang, Wanyu
;
Lv, Yuhong
;
Xue, Yang
;
Wu, Chenxing
;
Yao, Kun
;
Zhang, Chuanbao
;
Jin, Qiang
;
Huang, Rong
;
Li, Jiuyi
;
Sun, Yingyu
;
Su, Xiaodong
;
Jiang, Tao
;
Fan, Xiaolong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2017/12/04
glioma
molecular classification
receptor tyrosine kinase
HUMAN GLIOBLASTOMA CELLS
HIGH-GRADE GLIOMA
TUMOR ANGIOGENESIS
MALIGNANT GLIOMAS
HUMAN-DISEASE
EXPRESSION
PROGRESSION
LANDSCAPE
PDGFRA
EGFR
Expression analysis of receptor tyrosine kinase phosphorylation in a prostate cancer tissue and its para-carcinoma tissue
期刊论文
Chinese Journal of Andrology, 2015, 卷号: 29, 期号: 6, 页码: 33
作者:
Huang Tao
;
Zhang Qing
;
Ma Binbin
;
Liu Jingli
;
Liu Jianhe
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
prostatic neoplasms
receptor tyrosine kinase
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