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	Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance
	Zha, Gao-Feng; Qin, Hua-Li*; Youssif, Bahaa G. M.; Amjad, Muhammad Wahab; Raja, Maria Abdul Ghafoor; Abdelazeem, Ahmed H.; Bukhari, Syed Nasir Abbas*
刊名	European Journal of Medicinal Chemistry
	2017
卷号	135页码:34-48
关键词	Epidermal growth factor receptor (EGFR) BRAF Focal adhesion kinase (FAK) Tubulin polymerization Cancer cell lines MDR multidrug resistance EGFR epidermal growth factor receptor EMEA European Medicines Evaluation Agency FDA US Food and Drug Administration NSCLC non-small cell lung FAK focal adhesion kinase RTK receptor tyrosine kinases MAPK mitogen-activated protein kinase ABC ATP-binding cassette NF-kB NF-kappaB FERM Four-point-one, ezrin, radixin, moesin TMP Ligustrazine or tetramethylpyrazine Adr Adriamycin DRS death receptors TFN tumor necrosis factor PI propidium iodide TKIs tyrosine kinase inhibitors FAR fluorescence activity ratio HRMS high resolution mass spectra TLC thin layer chromatography UV ultraviolet DMEM Dulbecco's modified Eagle's medium DMSO dimethyl sulfoxide IBX 2-iodoxybenzoic acid
ISSN号	0223-5234
DOI	10.1016/j.ejmech.2017.04.025
URL标识	查看原文
WOS记录号	WOS:000403512100004
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/3371189
专题	武汉理工大学
作者单位	1.[Qin, Hua-Li 2.Bukhari, Syed Nasir Abbas 3.Zha, Gao-Feng] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Dept Pharmaceut Engn, 205 Luoshi Rd, Wuhan 430070, Peoples R China.
推荐引用方式 GB/T 7714	Zha, Gao-Feng,Qin, Hua-Li*,Youssif, Bahaa G. M.,et al. Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance[J]. European Journal of Medicinal Chemistry,2017,135:34-48.
APA	Zha, Gao-Feng.,Qin, Hua-Li*.,Youssif, Bahaa G. M..,Amjad, Muhammad Wahab.,Raja, Maria Abdul Ghafoor.,...&Bukhari, Syed Nasir Abbas*.(2017).Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance.European Journal of Medicinal Chemistry,135,34-48.
MLA	Zha, Gao-Feng,et al."Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance".European Journal of Medicinal Chemistry 135(2017):34-48.

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