Expression analysis of receptor tyrosine kinase phosphorylation in a prostate cancer tissue and its para-carcinoma tissue

CORC > 上海药物研究所 > 中国科学院上海药物研究所 > 药理学第一研究室

	Expression analysis of receptor tyrosine kinase phosphorylation in a prostate cancer tissue and its para-carcinoma tissue
	Huang Tao 4; Zhang Qing1 ; Ma Binbin 4; Liu Jingli 1; Liu Jianhe 3; Chu Chenlong 4; Wang Mingwei4 ; Yan Lei 1; Zhou Wenlong 2; Yu Qiang1
刊名	Chinese Journal of Andrology
	2015
卷号	29 期号:6 页码:33
关键词	prostatic neoplasms receptor tyrosine kinase
ISSN号	1008-0848
其他题名	前列腺癌及其癌旁组织中受体酪氨酸激酶的磷酸化分析
文献子类	Article
英文摘要	Objective To detect the expression and activation of receptor tyrosine kinases (RTKs) in prostate cancer tissue, and explore potential biomarkers and drug targets for prostate cancer. Methods The phosphorylation levels of 49 types of receptor tyrosine kinase in a prostate cancer tissue and its para-carcinoma tissue were examined by RTK microarray. Results The phosphorylation expressions of EGFR, ErbB2, ЕrbВ3, ErbB4, Insulin R, Axl, PDGFR а , PDGFR beta,M-CSFR,VEGFR2 were all upregulated in prostate cancer tissueas compared with that in its para-carcinoma tissue. Conclusion Phosphorylation of EGFR, ErbB2, ЕrbВ3, ErbB4, Insulin R, Axl, PDGFR alpha,PDGFR beta,M-CSFR, VEGFR2 in prostate cancer tissue may contribute to development and progress of prostate cancer.
WOS研究方向	Oncology (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:5510513
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/269270]
专题	药理学第一研究室
通讯作者	Yu Qiang
作者单位	1.Shanghai Institute of Materia Medica, Chinese Academy of Sciences.; 2.Department Urology of the Ruijin Hospital. 3.Department Urology of the Xinhua Hospital.; 4.Department of Urology, Luwan Branch of the Ruijin Hospital, Shanghai 200020, China.;
推荐引用方式 GB/T 7714	Huang Tao,Zhang Qing,Ma Binbin,et al. Expression analysis of receptor tyrosine kinase phosphorylation in a prostate cancer tissue and its para-carcinoma tissue[J]. Chinese Journal of Andrology,2015,29(6):33.
APA	Huang Tao.,Zhang Qing.,Ma Binbin.,Liu Jingli.,Liu Jianhe.,...&Yu Qiang.(2015).Expression analysis of receptor tyrosine kinase phosphorylation in a prostate cancer tissue and its para-carcinoma tissue.Chinese Journal of Andrology,29(6),33.
MLA	Huang Tao,et al."Expression analysis of receptor tyrosine kinase phosphorylation in a prostate cancer tissue and its para-carcinoma tissue".Chinese Journal of Andrology 29.6(2015):33.