Co-expression modules of NF1, PTEN and sprouty enable distinction of   adult diffuse gliomas according to pathway activities of receptor   tyrosine kinases

doi:10.18632/oncotarget.10359

CORC > 北京大学 > 生命科学学院

	Co-expression modules of NF1, PTEN and sprouty enable distinction of adult diffuse gliomas according to pathway activities of receptor tyrosine kinases
	Zhang, Wanyu ; Lv, Yuhong ; Xue, Yang ; Wu, Chenxing ; Yao, Kun ; Zhang, Chuanbao ; Jin, Qiang ; Huang, Rong ; Li, Jiuyi ; Sun, Yingyu ; Su, Xiaodong ; Jiang, Tao ; Fan, Xiaolong
刊名	ONCOTARGET
	2016
关键词	glioma molecular classification receptor tyrosine kinase HUMAN GLIOBLASTOMA CELLS HIGH-GRADE GLIOMA TUMOR ANGIOGENESIS MALIGNANT GLIOMAS HUMAN-DISEASE EXPRESSION PROGRESSION LANDSCAPE PDGFRA EGFR
DOI	10.18632/oncotarget.10359
英文摘要	Inter-individual variability causing elevated signaling of receptor tyrosine kinases (RTK) may have hampered the efficacy of targeted therapies. We developed a molecular signature for clustering adult diffuse gliomas based on the extent of RTK pathway activities. Glioma gene modules co-expressed with NF1 (NF1-M), Sprouty (SPRY-M) and PTEN (PTEN-M) were identified, their signatures enabled robust clustering of adult diffuse gliomas of WHO grades II-IV from five independent data sets into two subtypes with distinct activities of RAS-RAF-MEK-MAPK cascade and PI3KAKT pathway (named RMPA(high) and RMPA(low) subtypes) in a morphology-independent manner. The RMPA(high) gliomas were associated with poor prognosis compared to the RMPA(low) gliomas. The RMPA(high) and RMPA(low) glioma subtypes harbored unique sets of genomic alterations in the RTK signaling-related genes. The RMPA(high) gliomas were enriched in immature vessel cells and tumor associated macrophages, and both cell types expressed high levels of pro-angiogenic RTKs including MET, VEGFR1, KDR, EPHB4 and NRP1. In gliomas with major genomic lesions unrelated to RTK pathway, high RMPA signature was associated with short survival. Thus, the RMPA signatures capture RTK activities in both glioma cells and glioma microenvironment, and RTK signaling in the glioma microenvironment contributes to glioma progression.; National Natural Science Foundation [81472348]; Beijing Municipal Commission of Education; Beijing Normal University; SCI(E); PubMed; ARTICLE; XFan@bnu.edu.cn; 37; 59098-59114; 7
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/493531]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, Wanyu,Lv, Yuhong,Xue, Yang,et al. Co-expression modules of NF1, PTEN and sprouty enable distinction of adult diffuse gliomas according to pathway activities of receptor tyrosine kinases[J]. ONCOTARGET,2016.
APA	Zhang, Wanyu.,Lv, Yuhong.,Xue, Yang.,Wu, Chenxing.,Yao, Kun.,...&Fan, Xiaolong.(2016).Co-expression modules of NF1, PTEN and sprouty enable distinction of adult diffuse gliomas according to pathway activities of receptor tyrosine kinases.ONCOTARGET.
MLA	Zhang, Wanyu,et al."Co-expression modules of NF1, PTEN and sprouty enable distinction of adult diffuse gliomas according to pathway activities of receptor tyrosine kinases".ONCOTARGET (2016).