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上海药物研究所 [20]
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期刊论文 [20]
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2018 [3]
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2013 [2]
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Chemistry [2]
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Metabolism, pharmacokinetics, and hepatic disposition of xanthones and saponins on Zhimu treatments for exploratively interpreting the discrepancy between the herbal safety and timosaponin A3-induced hepatotoxicity
期刊论文
Acta pharmacologica Sinica, 2018, 卷号: 39, 期号: 12, 页码: 1923-1934
作者:
Xie, Yang
;
Zhou, Xu
;
Pei, Hu
;
Chen, Ming-Cang
;
Sun, Zhao-Lin
收藏
  |  
浏览/下载:96/0
  |  
提交时间:2019/01/08
Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS
期刊论文
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2018, 卷号: 66, 期号: 46, 页码: 12227-12235
作者:
Guo, Xiaozhen
;
Cheng, Mingcang
;
Hu, Pei
;
Shi, Zhangpeng
;
Chen, Shuoji
收藏
  |  
浏览/下载:269/0
  |  
提交时间:2019/01/08
norathyriol
pharmacokinetics
bioavailability
metabolism
HPLC-MS/MS
metabolismpharmacokineticsandhepaticdispositionofxanthonesandsaponinsonzhimutreatmentsforexplorativelyinterpretingthediscrepancybetweentheherbalsafetyandtimosaponina3inducedhepatotoxicity
期刊论文
actapharmacologicasinica, 2018, 卷号: 39, 期号: 12, 页码: 1923
作者:
Xie Yang
;
Zhou Xu
;
Pei Hu
;
Chen Mingcang
;
Sun Zhaolin
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2020/07/01
B-II
LIVER-INJURY
IN-VITRO
ANEMARRHENA-ASPHODELOIDES
OXIDATIVE STRESS
RAT PLASMA
A-III
MANGIFERIN
NORATHYRIOL
EXTRACT
Zhimu
timosaponin A3
mangiferin
pharmacokinetics
metabolism
hepatotoxicity
antioxidant
Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo
期刊论文
BIOFACTORS, 2016, 卷号: 42, 期号: 5, 页码: 533-544
作者:
Tian, Xiaoting
;
Gao, Yu
;
Xu, Zhou
;
Lian, Shan
;
Ma, Yuanjie
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2019/01/08
mangiferin
norathyriol
pharmacokinetics
metabolism
liver
Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 2: Influence of UGT, CYP450, P-gp, and enterobacteria and the potential interaction in Rhizoma Anemarrhenae decoction with timosaponin B2 as the major contributor
期刊论文
BIOFACTORS, 2016, 卷号: 42, 期号: 5, 页码: 545-555
作者:
Tian, Xiaoting
;
Xu, Zhou
;
Li, Zhixiong
;
Ma, Yuanjie
;
Lian, Shan
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/01/08
mangiferin
norathyriol
pharmacokinetics
drug-drug interaction
timosaponin B2
Rhizoma Anemarrhenae
Mangiferin attenuates the symptoms of dextran sulfate sodium-induced colitis in mice via NF-κB and MAPK signaling inactivation
期刊论文
International immunopharmacology, 2014, 卷号: 23, 期号: 1, 页码: 170-8
作者:
Dou, Wei
;
Zhang, Jingjing
;
Ren, Gaiyan
;
Ding, Lili
;
Sun, Aning
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters
期刊论文
ACTA PHARMACOLOGICA SINICA, 2014, 卷号: 35, 期号: 9, 页码: 1188-1198
作者:
Wu, Zhi-tao
;
Qi, Xin-ming
;
Sheng, Jing-jing
;
Ma, Lei-lei
;
Ni, Xuan
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/01/08
timosaponin A3
hepatotoxicity
cholestasis
bile acid
transporter
Cyp7a1
ROS
N-acetyl-L-cysteine
mangiferin
Xanthones from Swertia mussotii as Multitarget-Directed Antidiabetic Agents
期刊论文
CHEMMEDCHEM, 2014, 卷号: 9, 期号: 7, 页码: 1374-1377
作者:
Zheng, Huan-Huan
;
Luo, Cui-Ting
;
Chen, Heru
;
Lin, Juan-Na
;
Ye, Chun-Ling
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2019/01/08
aldose reductases
antioxidants
diabetes
alpha-glucosidases
multitarget inhibitors
xanthones
Antioxidant xanthones from Swertia mussotii, a high altitude plant
期刊论文
FITOTERAPIA, 2013, 卷号: 91, 页码: 140-147
作者:
Luo, Cui-Ting
;
Mao, Shuang-Shuang
;
Liu, Fang-Lan
;
Yang, Mao-xun
;
Chen, Heru
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2019/01/08
Swertia L.
Swertia mussotii
Xanthones
Antioxidant
ORAC
Characterization and Identification of Major Constituents in Baihe Zhimu Decoction by HPLC-MSn
期刊论文
ASIAN JOURNAL OF CHEMISTRY, 2013, 卷号: 25, 期号: 16, 页码: 8976-8980
作者:
Jiang, Weixin
;
Liu, Zhiyu
;
Wu, Bin
;
Huang, Chenggang
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2019/01/08
Baihe Zhimu decoction
Traditional Chinese medicine recipe
HPLC-MSn
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