Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS

doi:10.1021/acs.jafc.8b03763

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	Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS
	Guo, Xiaozhen 1,2; Cheng, Mingcang 1; Hu, Pei 1; Shi, Zhangpeng 1; Chen, Shuoji 1; Liu, Huan 1,2; Shi, Haoyun 1,2; Xu, Zhou 1; Tian, Xiaoting 1,2; Huang, Chenggang1,2
刊名	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
	2018-11-21
卷号	66 期号:46 页码:12227-12235
关键词	norathyriol pharmacokinetics bioavailability metabolism HPLC-MS/MS
ISSN号	0021-8561
DOI	10.1021/acs.jafc.8b03763
文献子类	Article
英文摘要	Norathyriol, an aglycone of mangiferin, is a bioactive tetrahydroxyxanthone present in mangosteen and many medicinal plants. However, the biological fate of norathyriol in vivo remains unclear. In this study, the absorption and metabolism of norathyriol in rats were evaluated through HPLC-MS/MS. Results showed that norathyriol was well absorbed, as indicated by its absolute bioavailability of 30.4%. Besides, a total of 21 metabolites of norathyriol were identified in rats, including methylated, glucuronidated, sulfated and glycosylated conjugates, which suggested norathyriol underwent extensive phase II metabolism. Among those metabolites, 15 metabolites were also identified in hepatocytes incubated with norathyriol, indicating the presence of hepatic metabolism. Furthermore, glucuronide and sulfate conjugates, rather than their parent compound, were found to be the main forms existing in vivo after administration of norathyriol, as implicated by the great increase of exposure of norathyriol determined after hydrolysis with beta-glucuronidase and sulfatase. The information obtained from this study contributes to better understanding of the pharmacological mechanism of norathyriol.
资助项目	National Natural Science Foundation of China[81030065] ; National Natural Science Foundation for Young Scientists of China[81603280] ; Strategic Priority Scientific and Technological Project of Chinese Academy of Science[XDA12040203] ; National Science and Technology Major Project of the Ministry of Science and Technology of China[2018ZX09731016-003] ; National Science and Technology Major Project of the Ministry of Science and Technology of China[2018ZX09201001-001-008]
WOS关键词	CHEMICAL-CONSTITUENTS ; NATURAL-PRODUCTS ; IN-VITRO ; INHIBITION ; DERIVATIVES ; XANTHONES ; SYSTEM
WOS研究方向	Agriculture ; Chemistry ; Food Science & Technology
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000451496600009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/279490]
专题	上海中药现代化研究中心
通讯作者	Tian, Xiaoting; Huang, Chenggang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Guo, Xiaozhen,Cheng, Mingcang,Hu, Pei,et al. Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2018,66(46):12227-12235.
APA	Guo, Xiaozhen.,Cheng, Mingcang.,Hu, Pei.,Shi, Zhangpeng.,Chen, Shuoji.,...&Huang, Chenggang.(2018).Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,66(46),12227-12235.
MLA	Guo, Xiaozhen,et al."Absorption, Metabolism, and Pharmacokinetics Profiles of Norathyriol, an Aglycone of Mangiferin, in Rats by HPLC-MS/MS".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 66.46(2018):12227-12235.