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食用蔬菜能吸收和积累微塑料
期刊论文
科学通报, 2019, 卷号: 64, 期号: 9, 页码: 928-934
作者:
李连祯
;
周倩
;
尹娜
;
涂晨
;
骆永明
收藏
  |  
浏览/下载:63/0
  |  
提交时间:2020/06/17
微塑料
生菜
聚苯乙烯微球
吸收
积累
健康风险
microplastics
lettuce
polystyrene microbeads
uptake
accumulation
human health risk
Microplastic (MP, 100 nm-5 mm) may present an attributable risk to ecosystem and human health, and its pollution has become a global environmental concern. Despite a wealth of information on the accumulation of MPs in aquatic species, there is no information on the uptake and accumulation of MPs by higher plants. Terrestrial edible plants are directly exposed to MPs when agricultural soil was applied with organic manure, sewage sludge as fertilizer or plastic mulching. In this paper, the uptake of two sizes of polystyrene (PS) microbeads (0.2 and 1.0 mum) and then their distribution and migration in an edible plant lettuce were firstly investigated based on laboratory experiments. We used fluorescent markers to track PS microbeads in plant tissues and found fluorescence to be a sensitive and reliable detection method. Sections from untreated control lettuce showed no autofluorescence. When roots were treated with fluorescently labeled PS microbeads, the microbeads could be identified by its fluorescence. Our main study investigated the uptake of 0.2 mum beads, as few luminescence signals were observed in lettuce roots for 1.0 mum beads in our experiment. We observed that 0.2 mum fluorescent microbeads were extracellularly trapped in the root cap mucilage (which is a highly hydrated polysaccharide) and a dark green tip (which was typical of lettuce roots exposed to label PS beads) was usually visible to the naked eye. Confocal images revealed that the PS luminescence signals were mainly located in the vascular system and on the cell walls of the cortex tissue of the roots, indicated that the beads passed through the intercellular space via the apoplastic transport system. Once inside the central cylinder, the 0.2 mum PS beads were transferred from the roots to the stems and leaves via the vascular system following the transpiration stream. We also observed that the PS beads adhered to one another and self-assembled systematically into grape-like and (chain) string-like clusters in the intercellular space of the root and stem vascular tissue of lettuce plant. In contrast to the root and stem, PS beads were dispersed in the leaf tissue. Here, for the first time we provide evidence of the adherence, uptake, accumulation, and translocation of submicrometer MPs within an edible plant. Our findings highlight the previously underappreciated human exposure pathway to MPs through the consumption of contaminated crops and emphasize the need for new management strategies to control the release of MPs waste products into the terrestrial environment. Ultimately, the potential impacts of low range sized MPs on food safety of crop plants and human health need to be urgently considered.
Role of C/EBP homologous protein and endoplasmic reticulum stress in asthma exacerbation by regulating the IL-4/signal transducer and activator of transcription 6/transcription factor EC/IL-4 receptor α positive feedback loop in M2 macrophages
期刊论文
Journal of Allergy and Clinical Immunology, 2017, 卷号: 140, 期号: 6, 页码: 1550-1561.e8
作者:
Wang, Yi
;
Zhu, Jianghui
;
Zhang, Lei
;
Zhang, Zhijun
;
He, Long
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/03
C/EBP homologous protein
asthma
macrophage
endoplasmic reticulum stress
AHR
Airway hyperresponsiveness
Atf4
Activating transcription factor 4
BALF
Bronchoalveolar lavage fluid
Bip
Binding immunoglobulin protein
ChIP
Chromatin immunoprecipitation
Chop
C/EBP homologous protein
eIF2α
Eukaryotic initiation factor 2α
ER
Endoplasmic reticulum
Fizz1
Found in inflammatory zone 1
IL-4Rα
IL-4 receptor α
OVA
Ovalbumin
PEF
Peak expiratory flow
Rn
Lung resistance
shRNA
Short hairpin RNA
STAT6
Signal transducer and activator of transcription 6
Tfec
Transcription factor EC
WT
Wild-type
Mid-late Pleistocene glacial evolution in the Grove Mountains, East Antarctica, constraints from cosmogenic Be-10 surface exposure dating of glacial erratic cobbles
期刊论文
QUATERNARY SCIENCE REVIEWS, 2016, 卷号: 145, 期号: 0, 页码: 71-81
作者:
Dong, GC (Dong, Guocheng)
;
Huang, FX (Huang, Feixin)
;
Caffee, MW (Caffee, Marc W.)
;
Huang, FX
;
Yi, CL (Yi, Chaolu)
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2017/09/26
Glacial HisTories From The East Antarctic Ice Sheet (Eais) Provide Keys To UnderstAndIng Correlations Between The Eats And Global Climate. They Are Especially Helpful In The Assessment Of Global Sea Level Change
And As a Means Of Quantifying The Magnitude Of pAst Glacial Activity And The RAte At Which Ice Responded To climAte Change. Given The Significance Of Eais Glacial hisTories
It Is Imperative That More Glacial Chronologic Data For thIs Region Be Obtained
Especially For The Mid-to-lAte Pleistocene. We Report Cosmogenic Be-10 Surface Exposure DAtIng Results From Glacially Transported Cobbles Embedded In Blue-ice moraIne MAterial At Mount hardIng
The Grove Mountains
Eais. Forty Exotic Cobbles Sampled AlOng Two PrOfiles (a And b) On This Blue-ice MoraIne Present Apparent Exposure-ages RangIng From 7.2 To 542.2 Ka. We Explore This Scattered Dataset By UsIng PrIncipal compOnent Analysis (Pca) To Identify Statistically Significant Trends In The Data. We Identify a correlatiOn betWeen Exposure-age And Distance Of The Cobbles From Mount hardIng. In prOfile a
Cobbles Further From Mount HardIng Yield Older Exposure-ages Than Those That Are Relatively Close. In Profile b
Cobbles Closer To Mount HardIng Are Found To Have Relatively Older Exposure-ages. In Term Of Glacial hisTory We Suggest That The Direction Of Ice Flow Changed durIng The Period From Similar To 60 To 200 Ka
And That Multiple Glacial Fluctuations Occurred In The Mid-late Pleistocene. (c) 2016 Elsevier Ltd. All Rights Reserved.
Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review
期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 5277-5285
作者:
Huang, Ruixue
;
Ding, Ping
;
Yang, Fei*
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/03
CDH1
as a tumor suppressor gene
contributes sporadic breast cancer (BC) progression. However
the association between CDH1 hypermethylation and BC
and its clinicopathological significance remains unclear. We conducted a meta-analysis to investigate the relationship between the CDH1 methylation profile and the major clinicopathological features. A detailed literature was searched through the electronic databases PubMed
Web of Science™
and EMBASE™ for related research publications. The data were extracted and assessed by two reviewers independently. Odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated and summarized respectively. The frequency of CDH1 methylation was significantly higher in invasive ductal carcinoma than in normal breast tissues (OR =5.83
95% CI 3.76–9.03
P<0.00001). CDH1 hypermethylation was significantly higher in estrogen receptor (ER)-negative BC than in ER-positive BC (OR =0.62
95% CI 0.43–0.87
P=0.007). In addition
we found that the CDH1 was significantly methylated in HER2-negative BC than in HER2-positive BC (OR =0.26
95% CI 0.15–0.44
P<0.00001). However
CDH1 methylation frequency was not associated with progesterone receptor (PR) status
or with grades
stages
or lymph node metastasis of BC patients. Our results indicate that CDH1 hypermethylation is a potential novel drug target for developing personalized therapy. CDH1 hypermethylation is strongly associated with ER-negative and HER2-negative BC
respectively
suggesting CDH1 methylation status could contribute to the development of novel therapeutic approaches for the treatment of ER-negative or HER2-negative BC with aggressive tumor biology.
Solitary skull metastasis as the first symptom of hepatocellular carcinoma: case report and literature review
期刊论文
Neuropsychiatric Disease and Treatment, 2014, 卷号: 10, 页码: 681-686
作者:
Guo, Xieli
;
Yin, Jiangliu
;
Jiang, Yugang*
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  |  
浏览/下载:5/0
  |  
提交时间:2019/12/03
Skull metastasis from hepatocellular carcinoma (HCC) is reported rarely. In addition
solitary skull metastasis as the first symptom of HCC is reported even less. Here
we reported a case of solitary skull metastasis as the first symptom of HCC and reviewed the literature on skull metastasis. A 49-year-old male patient was admitted to Jinjiang Hospital of Quanzhou Medical College with a painless parietal-occipital scalp mass
and he denied any history of hepatic disease. A cranial computed tomography demonstrated a hypervascular enhancement with osteolytic change in the right parietal-occipital region
cranial magnetic resonance imaging indicated a highly enhanced and osteolytic skull tumor
and abdominal computed tomography showed a huge tumor in the liver. The other examinations showed no other metastases. Laboratory data showed no liver dysfunction while hepatitis B surface antigen was positive
and alpha fetal protein level was high. A craniectomy was performed and the mass was totally removed. The histological diagnosis was skull metastasis from HCC. The patient was subsequently treated by transcatheter arterial chemoembolization. In a review of published literature
the incidence of skull metastasis from HCC in the period between 1990 and 2011 has significantly increased. The misdiagnosis rate of skull metastases as the first symptom from HCC was high. Therefore
it is necessary to give each patient with a scalp mass that has invaded the skull a liver ultrasound or computed tomography scan. On the other hand
we found that metastases that occurred in the calvaria site were more frequent than those that occurred in the skull base and facial skeleton. This may be worthy of further investigation in the future.
开源PaaS平台初探
期刊论文
《广东通信技术》, 2014, 卷号: 34, 页码: 9-12
作者:
李丽[1,2]
;
杨新章[2]
;
陆刚[2]
;
何震苇[2]
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/04/25
PAAS
开源
CLOUD Found
Cloudi
DOCKER
轻量 服务
大数据
Molecular Weight Dependency of Crystallization and Melting Behavior of beta-Nucleated Isotactic Polypropylene
期刊论文
journal of polymer science part b-polymer physics, 2014, 卷号: 52, 期号: 19, 页码: 1301-1308
Lu, Ying
;
Wang, Qiao
;
Men, Yongfeng
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2015/10/19
Compounds of isotactic polypropylene (iPP) and beta-nucleating agent were used to investigate the relationship between the development of beta phase and molecular weight in iPP under quiescent crystallization conditions by using wide angle X-ray diffraction and differential scanning calorimetry techniques. In all cases
the dependency of the formation of beta phase in iPP on molecular weight of iPP at a defined crystallization temperature range was found. The iPP with high molecular weight possessed a wide range of crystallization temperature in inducing rich beta phase. However
poor or even no beta phase was obtained for the samples with low molecular weight in the same range. In addition
an upper critical crystallization temperature of producing dominant beta phase was found at 125 degrees C. Beyond this temperature
a phenomenon of prevailing alpha phase became obvious. (C) 2014 Wiley Periodicals
Inc.
Gradient Structure-Induced Temperature Responsiveness in Styrene/Methyl Methacrylate Gradient Copolymers Micelles
期刊论文
macromolecular rapid communications, 2014, 卷号: 35, 期号: 3, 页码: 309-316
Zheng,Chao
;
Huang,Haiying
;
He,Tianbai
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2015/10/15
In this work
micelles are formed by gradient copolymer of styrene and methyl methacrylate in acetone-water mixture and their temperature responsiveness is investigated in a narrow range near room temperature. Three different kinds of structural transitions could be induced by temperature: unimers to micelle transition
shrinkage/stretching of micelles
and morphological transition from spherical micelles to vesicles. In addition
a model analysis on the interface of gradient copolymer micelle is made to better understand these phenomena. It is found that both position and composition of the interface could alter in response to the change in temperature. According to the experiments and model analysis
it is proposed that temperature responsiveness might be an intrinsic and universal property of gradient copolymer micelles
which only originates from the gradient structure.
中国城镇居民住房的需求与供给
研究报告
2013
邹至庄
;
牛霖琳
收藏
  |  
浏览/下载:48/0
  |  
提交时间:2013/11/08
住房需求
住房供给
联立方程
Abstract
This
paper
addresses
the
issue
of
demand
and
supply
for
residential
housing
in
urban
China
since
the
late
1980s
when
the
urban
housing
market
became
commercialized.
We
start
with
the
basic
premise
that
the
standard
theory
of
demand
for
and
supply
of
consumer
durable
goods
is
applicable
to
urban
housing
in
China
after
the
market
for
housing
was
established.
In
a
simultaneous
equations
framework
we
provide
estimates
of
income
and
price
elasticities
of
demand
and
price
elasticity
of
supply.
Analysis
of
aggregated
annual
data
from
1987
to
2006
shows
that
the
rapid
increase
of
urban
residential
housing
can
be
well
explained
by
the
forces
of
demand
and
supply
i.e.
growth
in
income
and
change
in
construction
cost
determines
the
aggregated
movement
in
housing
price
to
a
large
extent.
We
have
found
the
(long-run)
income
elasticity
of
demand
for
urban
housing
to
be
about
1
and
the
price
elasticity
of
demand
to
be
between
-0.5
and
-0.6.
The
price
elasticity
of
supply
of
the
total
stock
of
housing
is
about
0.83.
Keywords:
housing
demand
housing
supply
simultaneous
equations
Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells
期刊论文
PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299
作者:
收藏
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浏览/下载:28/0
  |  
提交时间:2015/05/14
2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)
one of the major components isolated from the traditional
Chinese medicine Rubia yunnanensis
exhibited inhibitory activity on the proliferation of several
human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay
and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle
arrest in human cervical carcinoma HeLa cells. Further
MTA was found to induce apoptosis of HeLa cells
through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and
release of cytochrome c into the cytosol
which caused the cleavage of caspase and poly(ADP-ribose)
polymerase and finally triggered the apoptosis. Furthermore
the p53/p21/Cdc2-cyclin B1 signaling was
found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of
cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused
the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of
R. yunnanensis
a folk anti-cancer herb used in Yunnan
China.
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