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	Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review
	Huang, Ruixue; Ding, Ping; Yang, Fei*
刊名	Drug Design, Development and Therapy
	2015
卷号	9页码:5277-5285
关键词	CDH1 as a tumor suppressor gene contributes sporadic breast cancer (BC) progression. However the association between CDH1 hypermethylation and BC and its clinicopathological significance remains unclear. We conducted a meta-analysis to investigate the relationship between the CDH1 methylation profile and the major clinicopathological features. A detailed literature was searched through the electronic databases PubMed Web of Science™ and EMBASE™ for related research publications. The data were extracted and assessed by two reviewers independently. Odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated and summarized respectively. The frequency of CDH1 methylation was significantly higher in invasive ductal carcinoma than in normal breast tissues (OR =5.83 95% CI 3.76–9.03 P<0.00001). CDH1 hypermethylation was significantly higher in estrogen receptor (ER)-negative BC than in ER-positive BC (OR =0.62 95% CI 0.43–0.87 P=0.007). In addition we found that the CDH1 was significantly methylated in HER2-negative BC than in HER2-positive BC (OR =0.26 95% CI 0.15–0.44 P<0.00001). However CDH1 methylation frequency was not associated with progesterone receptor (PR) status or with grades stages or lymph node metastasis of BC patients. Our results indicate that CDH1 hypermethylation is a potential novel drug target for developing personalized therapy. CDH1 hypermethylation is strongly associated with ER-negative and HER2-negative BC respectively suggesting CDH1 methylation status could contribute to the development of novel therapeutic approaches for the treatment of ER-negative or HER2-negative BC with aggressive tumor biology.
ISSN号	1177-8881
DOI	10.2147/DDDT.S86929
URL标识	查看原文
WOS记录号	WOS:000361793600001
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/3345931
专题	中南大学
作者单位	1.[Ding, Ping 2.Huang, Ruixue 3.Yang, Fei] Cent S Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Changsha 410083, Hunan, Peoples R China.
推荐引用方式 GB/T 7714	Huang, Ruixue,Ding, Ping,Yang, Fei*. Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review[J]. Drug Design, Development and Therapy,2015,9:5277-5285.
APA	Huang, Ruixue,Ding, Ping,&Yang, Fei*.(2015).Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review.Drug Design, Development and Therapy,9,5277-5285.
MLA	Huang, Ruixue,et al."Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review".Drug Design, Development and Therapy 9(2015):5277-5285.

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