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上海药物研究所 [4]
中南大学 [2]
大连理工大学 [1]
南开大学 [1]
中国医学科学院 北京... [1]
合肥物质科学研究院 [1]
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期刊论文 [10]
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2022 [1]
2020 [2]
2015 [1]
2014 [3]
2013 [1]
2011 [1]
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Key Considerations in Targeted Protein Degradation Drug Discovery and Development
期刊论文
FRONTIERS IN CHEMISTRY, 2022, 卷号: 10
作者:
Qin, Liena
;
Dai, Han
;
Wang, Junfeng
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2022/12/23
targeted protein degradation
PROTAC
molecular glue
chemically induced proximity
drug discovery and development
Recent advances in dopaminergic strategies for the treatment of Parkinson's disease
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Mao, Qi
;
Qin, Wang-zhi
;
Zhang, Ao
;
Ye, Na
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Parkinson's disease
dopamine
D-1 receptor
D-2 receptor
allosteric modulator
neuroprotection
multitarget
drug discovery and development
neurodegenerative diseases
recentadvancesindopaminergicstrategiesforthetreatmentofparkinsonsdisease
期刊论文
actapharmacologicasinica, 2020, 卷号: 41, 期号: 4, 页码: 471
作者:
Mao Qi
;
Qin Wangzhi
;
Zhang Ao
;
Ye Na
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
Parkinson’s disease
dopamine
D_1 receptor
D_2 receptor
allosteric modulator
neuroprotection
multitarget
drug discovery and development
neurodegenerative diseases
Genomics and Evolution in Traditional Medicinal Plants: Road to a Healthier Life
期刊论文
2015, 卷号: 11, 页码: 197-212
作者:
Hao, Da-Cheng
;
Xiao, Pei-Gen
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/13
genome evolution
medicinal plants
phylogeny
phylogenomics
drug discovery and development
TCM-based new drug discovery and development in China
期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2014, 卷号: 12, 期号: 4, 页码: 241-250
作者:
Wv Wan-Ying
;
Hou Jin-Jun
;
Long Hua-Li
;
Yang Wen-Zhi
;
Mang Jian
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/01/08
China
China Food and Drug Administration (CFDA)
Traditional Chinese Medicine
Regulatory classification
Drug discovery
Drug development
The Screening Research of Anti-Inflammatory Bioactive Markers from Different Flowering Phases of Flos Lonicerae Japonicae.
期刊论文
PLoS ONE, 2014, 卷号: Vol.9 No.5, 页码: 1-10
作者:
Jiang, Min
;
Han, Yan-qi
;
Zhou, Meng-ge
;
Zhao, Hong-zhi
;
Xiao, Xue
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/02/27
Biochemistry
Biology and life sciences
Cytokines
Developmental biology
Drug discovery
Drug research and development
Flowering plants
Immune response
Immune system
Immunology
Inflammation
Medicine and health sciences
Molecular development
Organisms
Pharmacology
Plant growth and development
Plants
Research Article
SABRE: Ligand/Structure-Based Virtual Screening Approach Using Consensus Molecular-Shape Pattern Recognition
期刊论文
JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2014, 卷号: 54, 页码: 338-346
作者:
Wei, Ning-Ning
;
Hamza, Adel
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2019/12/09
Active compounds
Binding pockets
Chemical similarity
Linear combinations
Molecular shapes
Receptor binding site
Structural diversity
Virtual Screening, Algorithms
Binding sites
Data fusion
Ligands
Molecules
Pattern recognition, Three dimensional, ligand
protein, algorithm
automated pattern recognition
binding site
biology
chemical database
chemical structure
chemical structure
chemistry
computer interface
computer program
drug database
drug development
drug screening
human
metabolism
procedures
statistics and numerical data
validation study, Algorithms
Binding Sites
Computational Biology
Databases, Chemical
Databases, Pharmaceutical
Drug Discovery
Drug Evaluation, Preclinical
Humans
Ligands
Models, Molecular
Molecular Structure
Pattern Recognition, Automated
Proteins
Software
User-Computer Interface
Genome-Scale Screening of Drug-Target Associations Relevant to Ki Using a Chemogenomics Approach
期刊论文
PLOS ONE, 2013, 卷号: 8, 期号: 4, 页码: e57680
作者:
Cao, Dong-Sheng
;
Liang, Yi-Zeng*
;
Deng, Zhe
;
Hu, Qian-Nan
;
He, Min
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/03
Drug interactions,Drug discovery,Protein interactions,Forecasting,Protein sequencing,Trees,Serotonin,Drug research and development
Progress in function and mechanism study of heparan sulfate proteoglycan
期刊论文
Chinese Bulletin of Life Sciences, 2011, 卷号: 23, 期号: 7, 页码: 648-661
作者:
QIU Hong
;
DING Kan
收藏
  |  
浏览/下载:45/0
  |  
提交时间:2019/01/08
heparan sulfate proteoglycan (HSPG)
syndecan
glypican
perlecan
agrin
drug discovery and development
clinical diganostics
Imatinib and Nilotinib Reverse Multidrug Resistance in Cancer Cells by Inhibiting the Efflux Activity of the MRP7 (ABCC10)
期刊论文
PLOS ONE, 2009, 卷号: 4, 期号: 10, 页码: e7520
作者:
Shen, Tong*
;
Kuang, Ye-Hong
;
Ashby, Charles R., Jr.
;
Lei, Yu
;
Chen, Angel
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/03
Cancer treatment,Protein expression,Cancer drug discovery,MTT assay,Drug research and development,Drug synthesis,Drug therapy,Nitrocellulose
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