Recent advances in dopaminergic strategies for the treatment of Parkinson's disease

doi:10.1038/s41401-020-0365-y

	Recent advances in dopaminergic strategies for the treatment of Parkinson's disease
	Mao, Qi 1,3; Qin, Wang-zhi 1,3; Zhang, Ao 2,4,5; Ye, Na 1,3
刊名	ACTA PHARMACOLOGICA SINICA
	2020-02-28
页码	12
关键词	Parkinson's disease dopamine D-1 receptor D-2 receptor allosteric modulator neuroprotection multitarget drug discovery and development neurodegenerative diseases
ISSN号	1671-4083
DOI	10.1038/s41401-020-0365-y
通讯作者	Ye, Na(yena@suda.edu.cn)
英文摘要	Parkinson's disease (PD) is the second most common progressive neurodegenerative disease worldwide. However, there is no available therapy reversing the neurodegenerative process of PD. Based on the loss of dopamine or dopaminergic dysfunction in PD patients, most of the current therapies focus on symptomatic relief to improve patient quality of life. As dopamine replacement treatment remains the most effective symptomatic pharmacotherapy for PD, herein we provide an overview of the current pharmacotherapies, summarize the clinical development status of novel dopaminergic agents, and highlight the challenge and opportunity of emerging preclinical dopaminergic approaches aimed at managing the features and progression of PD.
资助项目	National Natural Science Foundation of China[81703330] ; Natural Science Foundation of Jiangsu Province[BK20170347] ; Priority Academic Program Development of the Jiangsu Higher Education Institutes (PAPD) ; Jiangsu Key Laboratory of Neuropsychiatric Diseases[BM2013003]
WOS关键词	METABOTROPIC GLUTAMATE RECEPTORS ; MONOAMINE-OXIDASE INHIBITION ; LEVODOPA-INDUCED DYSKINESIA ; SUBTYPE-SELECTIVE AGENTS ; IN-VIVO CHARACTERIZATION ; 5-HT1A DUAL-AGONIST ; MAO-B INHIBITORS ; ALLOSTERIC MODULATORS ; D2/D3 AGONIST ; NONDOPAMINERGIC TREATMENTS
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
语种	英语
出版者	NATURE PUBLISHING GROUP
WOS记录号	WOS:000517048200003
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/281449]
专题	中国科学院上海药物研究所
通讯作者	Ye, Na
作者单位	1.Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China 2.Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 3.Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou 215123, Peoples R China 4.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Mao, Qi,Qin, Wang-zhi,Zhang, Ao,et al. Recent advances in dopaminergic strategies for the treatment of Parkinson's disease[J]. ACTA PHARMACOLOGICA SINICA,2020:12.
APA	Mao, Qi,Qin, Wang-zhi,Zhang, Ao,&Ye, Na.(2020).Recent advances in dopaminergic strategies for the treatment of Parkinson's disease.ACTA PHARMACOLOGICA SINICA,12.
MLA	Mao, Qi,et al."Recent advances in dopaminergic strategies for the treatment of Parkinson's disease".ACTA PHARMACOLOGICA SINICA (2020):12.