Progress in function and mechanism study of heparan sulfate proteoglycan

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	Progress in function and mechanism study of heparan sulfate proteoglycan
	QIU Hong; DING Kan
刊名	Chinese Bulletin of Life Sciences
	2011
卷号	23 期号:7 页码:648-661
关键词	heparan sulfate proteoglycan (HSPG) syndecan glypican perlecan agrin drug discovery and development clinical diganostics
ISSN号	1004-0374
其他题名	硫酸乙酰肝素蛋白聚糖的功能机制研究进展
文献子类	Article
英文摘要	Heparan sulfate proteoglycan (HSPG)is a glycoconjugate composed of core protein to which heparan sulfate chains are attached.They are widely distributed on the cell membrane and extracellular matrix.Syndecans and glypicans are the main heparan sulfate proteoglycan located on the cell membrane,while perlecan and agrin are the most investigated heparan sulfate proteoglycan in the extracellular matrix.They play an important role during physiological and pathological conditions including development,wound healing,cancer development,infection,immune response.Their function can be attributed to both the core protein and the attached heparan sulfate chains.In this review,we would like to summarize the recent progress of the heparan sulfate proteoglycan research.In the meantime,we will also highlight the potential of heparan sulfate proteoglycan as target for drug discovery & development and marker for clinical diagnostics.
资助项目	中国科学院百人计划择优资助基金[00000000]
WOS研究方向	Biochemistry & Molecular Biology (provided by Clarivate Analytics)
语种	中文
CSCD记录号	CSCD:4273262
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/267870]
专题	药理学第三研究室
通讯作者	DING Kan
作者单位	Glycobiology and Glycochemistry Lab,Shanghai Institutes of Materia Medica,Chinese Academy of Sciences, Shanghai 201203, China.
推荐引用方式 GB/T 7714	QIU Hong,DING Kan. Progress in function and mechanism study of heparan sulfate proteoglycan[J]. Chinese Bulletin of Life Sciences,2011,23(7):648-661.
APA	QIU Hong,&DING Kan.(2011).Progress in function and mechanism study of heparan sulfate proteoglycan.Chinese Bulletin of Life Sciences,23(7),648-661.
MLA	QIU Hong,et al."Progress in function and mechanism study of heparan sulfate proteoglycan".Chinese Bulletin of Life Sciences 23.7(2011):648-661.