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浏览/检索结果: 共4条，第1-4条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择发表日期升序发表日期降序作者升序作者降序提交时间升序提交时间降序题名升序题名降序 Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review 期刊论文 Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 5277-5285 作者:  Huang, Ruixue;  Ding, Ping;  Yang, Fei* 收藏  |  浏览/下载：15/0  |  提交时间：2019/12/03 CDH1  as a tumor suppressor gene  contributes sporadic breast cancer (BC) progression. However  the association between CDH1 hypermethylation and BC  and its clinicopathological significance remains unclear. We conducted a meta-analysis to investigate the relationship between the CDH1 methylation profile and the major clinicopathological features. A detailed literature was searched through the electronic databases PubMed  Web of Science™  and EMBASE™ for related research publications. The data were extracted and assessed by two reviewers independently. Odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated and summarized respectively. The frequency of CDH1 methylation was significantly higher in invasive ductal carcinoma than in normal breast tissues (OR =5.83  95% CI 3.76–9.03  P<0.00001). CDH1 hypermethylation was significantly higher in estrogen receptor (ER)-negative BC than in ER-positive BC (OR =0.62  95% CI 0.43–0.87  P=0.007). In addition  we found that the CDH1 was significantly methylated in HER2-negative BC than in HER2-positive BC (OR =0.26  95% CI 0.15–0.44  P<0.00001). However  CDH1 methylation frequency was not associated with progesterone receptor (PR) status  or with grades  stages  or lymph node metastasis of BC patients. Our results indicate that CDH1 hypermethylation is a potential novel drug target for developing personalized therapy. CDH1 hypermethylation is strongly associated with ER-negative and HER2-negative BC  respectively  suggesting CDH1 methylation status could contribute to the development of novel therapeutic approaches for the treatment of ER-negative or HER2-negative BC with aggressive tumor biology.   A High-Throughput Screening System for Arabidopsis Transcription Factors and Its Application to Med25-Dependent Transcriptional Regulation 期刊论文 分子植物, 2011 Ou, Bin; Yin, Kang-Quan; Liu, Sai-Nan; Yang, Yan; Gu, Tren; Hui, Jennifer Man Wing; Zhang, Li; Miao, Jin; Kondou, Youichi; Matsui, Minami; Gu, Hong-Ya; Qu, Li-Jia 收藏  |  浏览/下载：3/0  |  提交时间：2015/11/10 Transcription factors  Arabidopsis  yeast-one-hybrid  yeast-two-hybrid  Med25  PROTEIN-PROTEIN INTERACTIONS  PLANT DEFENSIN GENE  RNA-POLYMERASE-II  ONE-HYBRID SYSTEM  SALICYLIC-ACID  MEDIATOR COMPLEX  FLOWERING-TIME  PR-1 GENE  JASMONATE  ACTIVATION   Expression analysis of light-regulated genes isolated from a full-length-enriched cDNA library of Onosma paniculatum cell cultures 期刊论文 Journal of Plant Physiology, 2008, 卷号: 165, 期号: 14, 页码: 1474-1482 作者:  Qi, Jin-Liang;  Zhang, Wen-Ju;  Liu, Shao-Hua 收藏  |  浏览/下载：12/0  |  提交时间：2019/12/23 cDNA library  Ethylene  Gene expression  Light signal  Shikonin  4CL  4-coumarate: CoA ligase gene  ACC synthase  1-amino-cyclopropane-1-carboxylate synthase  ARD  aci-reductone dioxygenase  C4H  cinnamic acid 4-hydroxylase gene  CO  carbon monoxide  ds-cDNA  double-strand cDNA  ERF  ethylene responsive factor  EST  expressed sequence tag  HMGR  3-hydroxy-3-methylglutaryl-coenzyme A reductase gene  LD-PCR  long-distance PCR  LeDI  Lithospermum erythrorhizon dark-inducible gene  LePGT  p-hydroxybenzoate 3-geranyltransferase gene  MTA  5′-methylthioadenosine  NCBInr  non-redundant databases of National Center of Biotechnology Institute  PAL  phenylalanine ammonialyase gene  phyA  phytochrome A  phyAphyB  phytochrome A and phytochrome B double mutants  PR  pathogenesis-related gene  PTI5  PTO-interacting protein 5  SAM  S-adenosylmethionine  SAMDC  SAM-decarboxylase  SMART  Switching Mechanism At 5′-end of RNA Transcript   WRKY62 transcription factor acts downstream of cytosolic NPR1 and negatively regulates jasmonate-responsive gene expression 期刊论文 plant and cell physiology, 2007 Mao, Peng; Duan, Mingrui; Wei, Chunhong; Li, Yi 收藏  |  浏览/下载：3/0  |  提交时间：2015/11/14 cytosolic  jasmonate  NPR1  salicylate  WRKY62  SYSTEMIC ACQUIRED-RESISTANCE  DNA-BINDING PROTEINS  ARABIDOPSIS-THALIANA  SALICYLIC-ACID  PLANT DEFENSE  SIGNALING PATHWAYS  PR-1 GENE  DISEASE-RESISTANCE  TGA FACTORS  CROSS-TALK