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科研机构
北京大学 [2]
中南大学 [1]
湖南农业大学 [1]
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期刊论文 [4]
发表日期
2015 [1]
2011 [1]
2008 [1]
2007 [1]
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Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review
期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 5277-5285
作者:
Huang, Ruixue
;
Ding, Ping
;
Yang, Fei*
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/12/03
CDH1
as a tumor suppressor gene
contributes sporadic breast cancer (BC) progression. However
the association between CDH1 hypermethylation and BC
and its clinicopathological significance remains unclear. We conducted a meta-analysis to investigate the relationship between the CDH1 methylation profile and the major clinicopathological features. A detailed literature was searched through the electronic databases PubMed
Web of Science™
and EMBASE™ for related research publications. The data were extracted and assessed by two reviewers independently. Odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated and summarized respectively. The frequency of CDH1 methylation was significantly higher in invasive ductal carcinoma than in normal breast tissues (OR =5.83
95% CI 3.76–9.03
P<0.00001). CDH1 hypermethylation was significantly higher in estrogen receptor (ER)-negative BC than in ER-positive BC (OR =0.62
95% CI 0.43–0.87
P=0.007). In addition
we found that the CDH1 was significantly methylated in HER2-negative BC than in HER2-positive BC (OR =0.26
95% CI 0.15–0.44
P<0.00001). However
CDH1 methylation frequency was not associated with progesterone receptor (PR) status
or with grades
stages
or lymph node metastasis of BC patients. Our results indicate that CDH1 hypermethylation is a potential novel drug target for developing personalized therapy. CDH1 hypermethylation is strongly associated with ER-negative and HER2-negative BC
respectively
suggesting CDH1 methylation status could contribute to the development of novel therapeutic approaches for the treatment of ER-negative or HER2-negative BC with aggressive tumor biology.
A High-Throughput Screening System for Arabidopsis Transcription Factors and Its Application to Med25-Dependent Transcriptional Regulation
期刊论文
分子植物, 2011
Ou, Bin
;
Yin, Kang-Quan
;
Liu, Sai-Nan
;
Yang, Yan
;
Gu, Tren
;
Hui, Jennifer Man Wing
;
Zhang, Li
;
Miao, Jin
;
Kondou, Youichi
;
Matsui, Minami
;
Gu, Hong-Ya
;
Qu, Li-Jia
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  |  
浏览/下载:3/0
  |  
提交时间:2015/11/10
Transcription factors
Arabidopsis
yeast-one-hybrid
yeast-two-hybrid
Med25
PROTEIN-PROTEIN INTERACTIONS
PLANT DEFENSIN GENE
RNA-POLYMERASE-II
ONE-HYBRID SYSTEM
SALICYLIC-ACID
MEDIATOR COMPLEX
FLOWERING-TIME
PR-1 GENE
JASMONATE
ACTIVATION
Expression analysis of light-regulated genes isolated from a full-length-enriched cDNA library of Onosma paniculatum cell cultures
期刊论文
Journal of Plant Physiology, 2008, 卷号: 165, 期号: 14, 页码: 1474-1482
作者:
Qi, Jin-Liang
;
Zhang, Wen-Ju
;
Liu, Shao-Hua
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  |  
浏览/下载:12/0
  |  
提交时间:2019/12/23
cDNA library
Ethylene
Gene expression
Light signal
Shikonin
4CL
4-coumarate: CoA ligase gene
ACC synthase
1-amino-cyclopropane-1-carboxylate synthase
ARD
aci-reductone dioxygenase
C4H
cinnamic acid 4-hydroxylase gene
CO
carbon monoxide
ds-cDNA
double-strand cDNA
ERF
ethylene responsive factor
EST
expressed sequence tag
HMGR
3-hydroxy-3-methylglutaryl-coenzyme A reductase gene
LD-PCR
long-distance PCR
LeDI
Lithospermum erythrorhizon dark-inducible gene
LePGT
p-hydroxybenzoate 3-geranyltransferase gene
MTA
5′-methylthioadenosine
NCBInr
non-redundant databases of National Center of Biotechnology Institute
PAL
phenylalanine ammonialyase gene
phyA
phytochrome A
phyAphyB
phytochrome A and phytochrome B double mutants
PR
pathogenesis-related gene
PTI5
PTO-interacting protein 5
SAM
S-adenosylmethionine
SAMDC
SAM-decarboxylase
SMART
Switching Mechanism At 5′-end of RNA Transcript
WRKY62 transcription factor acts downstream of cytosolic NPR1 and negatively regulates jasmonate-responsive gene expression
期刊论文
plant and cell physiology, 2007
Mao, Peng
;
Duan, Mingrui
;
Wei, Chunhong
;
Li, Yi
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  |  
浏览/下载:3/0
  |  
提交时间:2015/11/14
cytosolic
jasmonate
NPR1
salicylate
WRKY62
SYSTEMIC ACQUIRED-RESISTANCE
DNA-BINDING PROTEINS
ARABIDOPSIS-THALIANA
SALICYLIC-ACID
PLANT DEFENSE
SIGNALING PATHWAYS
PR-1 GENE
DISEASE-RESISTANCE
TGA FACTORS
CROSS-TALK
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