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Characteristics and potential role of M2 macrophages in COPD 期刊论文
International Journal of Chronic Obstructive Pulmonary Disease, 2017, 卷号: 12, 页码: 3029-3039
作者:  He, Shengyang;  Xie, Lihua*;  Lu, Junjuan;  Sun, Shenghua*
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03
Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 5277-5285
作者:  Huang, Ruixue;  Ding, Ping;  Yang, Fei*
收藏  |  浏览/下载：15/0  |  提交时间：2019/12/03
CDH1  as a tumor suppressor gene  contributes sporadic breast cancer (BC) progression. However  the association between CDH1 hypermethylation and BC  and its clinicopathological significance remains unclear. We conducted a meta-analysis to investigate the relationship between the CDH1 methylation profile and the major clinicopathological features. A detailed literature was searched through the electronic databases PubMed  Web of Science™  and EMBASE™ for related research publications. The data were extracted and assessed by two reviewers independently. Odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated and summarized respectively. The frequency of CDH1 methylation was significantly higher in invasive ductal carcinoma than in normal breast tissues (OR =5.83  95% CI 3.76–9.03  P<0.00001). CDH1 hypermethylation was significantly higher in estrogen receptor (ER)-negative BC than in ER-positive BC (OR =0.62  95% CI 0.43–0.87  P=0.007). In addition  we found that the CDH1 was significantly methylated in HER2-negative BC than in HER2-positive BC (OR =0.26  95% CI 0.15–0.44  P<0.00001). However  CDH1 methylation frequency was not associated with progesterone receptor (PR) status  or with grades  stages  or lymph node metastasis of BC patients. Our results indicate that CDH1 hypermethylation is a potential novel drug target for developing personalized therapy. CDH1 hypermethylation is strongly associated with ER-negative and HER2-negative BC  respectively  suggesting CDH1 methylation status could contribute to the development of novel therapeutic approaches for the treatment of ER-negative or HER2-negative BC with aggressive tumor biology.  
基于WEB的学报在线稿件管理系统设计与实现 学位论文
2014, 2013
周莹洁
收藏  |  浏览/下载：3/0  |  提交时间：2016/01/13
Single-cell clones of liver cancer stem cells have the potential of differentiating into different types of tumor cells 期刊论文
cell death disease, 2013
Liu, H.; Zhang, W.; Jia, Y.; Yu, Q.; Grau, G. E.; Peng, L.; Ran, Y.; Yang, Z.; Deng, H.; Lou, J.
收藏  |  浏览/下载：4/0  |  提交时间：2015/11/16
Astrocytic Ca2+ waves mediate activation of extrasynaptic NMDA receptors in hippocampal neurons to aggravate brain damage during ischemia 期刊论文
疾病神经生物学实验神经学b辑, 2013
Dong, Qi-ping; He, Jing-quan; Chai, Zhen
收藏  |  浏览/下载：2/0  |  提交时间：2015/11/10
Regulation of Endothelial Progenitor Cell Release by Wnt Signaling in Bone Marrow 期刊论文
http://dx.doi.org/10.1167/iovs.13-13163, 2013
Liu, Xiaochen; McBride, Jeffrey; Zhou, Yueping; Liu, Zuguo; Ma, Jian-xing; 周跃平; 刘祖国
收藏  |  浏览/下载：2/0  |  提交时间：2015/07/22
Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing 期刊论文
bmc microbiology, 2009
Wang, Huiping; Kong, Fanrong; Sorrell, Tania C.; Wang, Bin; McNicholas, Paul; Pantarat, Namfon; Ellis, David; Xiao, Meng; Widmer, Fred; Chen, Sharon C. A.
收藏  |  浏览/下载：5/0  |  提交时间：2015/11/16
UV-VUV spectral irradiance responsivity calibration for space remote sensing spectroradiometer (EI CONFERENCE) 会议论文
Advanced Materials and Devices for Sensing and Imaging III, November 12, 2007 - November 14, 2007, Beijing, China
Yu H.; Shurong W.; Guanyu L.; Longqi W.
收藏  |  浏览/下载：14/0  |  提交时间：2013/03/25
In order to overcome the irradiance responsivity calibration troubles caused by the weak response of most spectral radiometers in ultraviolet band and poor ratio of signal to noise  and to meet special calibration condition for some remote sensing spectroradiometers in space  a spectral irradiance responsivity calibration unit based on parallel light illumination mode is established  it is composed of a 150W deuterium lamp and a spherical mirror. The calibration unit gets the output standard value of spectral irradiance by irradiance transfer  this way avoids the spectral reflectance measurement difficulty of the spherical mirror. A flight spectral radiometer model used for space remote sense was calibrated in range from 160nm to 300nm  the calibration error of spectral irradiance responsivity is 4.7%. Some factors which contribute to calibration uncertainties are discussed.  
Geometrical modulation transfer function of different active pixel of CMOS APS (EI CONFERENCE) 会议论文
2nd International Symposium on Advanced Optical Manufacturing and Testing Technologies: Optical Test and Measurement Technology and Equipment, November 2, 2005 - November 5, 2005, Zian, China
Li J.; Liu J.; Hao Z.
收藏  |  浏览/下载：20/0  |  提交时间：2013/03/25
The geometrical Modulation Transfer Function (MTF) of CMOS APS (active pixel sensor) is analyzed in this paper. Advanced APS have been designed and fabricated where different pixel shapes such as square  rectangle and L shape  were placed  because the amplifier circuit and other function circuits inter pixel of APS take up some pixel area. MTF is an important figure of merit in focal plane array imaging sensors. Research on analyzing the MTF for the proper pixel shape is currently in progress for a centroidal configuration of a target position. MTF will give us a more complete understanding of the tradeoffs opposed by the different pixel designs and by the signal processing conditions. Based on image sensor sampling and reconstructing model  the MTF expression of any active pixel shape has been deduced in this paper. According to actual pixel shape  three different active area pixels were analyzed  they were square  rectangle  and L shape  their Fill Factor (FF) is 30%  44% and 55%  respectively. Results of simulation experiments indicate that different pixel geometrical characteristics contribute significantly to the figures of their MTF. Different geometrical shape of active sensitive area of pixel and different station in pixel would influence MTF figures. The analysis results are important in designing better APS pixel and more important in analyzing imaging system performance of APS subpixel precision system.  
a new two-dimensional discrete chaotic system with rational fraction and its tracking and synchronization 期刊论文
CHAOS SOLITONS & FRACTALS, 2005, 卷号: 24, 期号: 4, 页码: 1135-1143
Chang L; Lu JA; Deng XM
收藏  |  浏览/下载：9/0  |  提交时间：2011/07/28

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