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复旦大学上海医学院 [10]
武汉物理与数学研究所 [8]
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Imatinib protects against human beta-cell death via inhibition of mitochondrial respiration and activation of AMPK
期刊论文
CLINICAL SCIENCE, 2021, 卷号: 135, 期号: 19, 页码: 2243-2263
作者:
Elksnis, Andris
;
Schiffer, Tomas A.
;
Palm, Fredrik
;
Wang, Yun
;
Cen, Jing
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/12/01
Bio-inspired amyloid polypeptides: From self-assembly to nanostructure design and biotechnological applications
期刊论文
APPLIED MATERIALS TODAY, 2021, 卷号: 22, 页码: 23
作者:
Lai, Yi
;
Li, Fenglin
;
Zou, Zhifeng
;
Saeed, Madiha
;
Xu, Zhiai
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2021/05/24
Amyloid polypeptide
Bio-inspired
Nanomedicine
Self-assembly
Oligomannuronate prevents mitochondrial dysfunction induced by IAPP in RINm5F islet cells by inhibition of JNK activation and cell apoptosis
期刊论文
Chinese Medicine, 2020, 卷号: 15, 期号: 1, 页码: 1-12.
作者:
Xi Liu
;
Qiong Li
;
Xiaolei Cheng
;
Zhichun Liu
;
Xiaoliang Zhao
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2022/03/10
Oligomannuronate
Type 2 diabetes
Islet amyloid polypeptide
JNK activation
Mitochondrial dysfunction
RINm5F cells
Interplay between Alzheimer's disease and global glucose metabolism revealed by the metabolic profile alterations of pancreatic tissue and serum in APP/PS1 transgenic mice
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 10, 页码: 1259-1268
作者:
Liu, Xia
;
Wang, Wei
;
Chen, Hua-li
;
Zhang, Hai-yan
;
Zhang, Nai-xia
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
Alzheimer's disease
type 2 diabetes
APP/PS1 transgenic mice
metabolomics
NMR
glucose metabolism dysfunctions
All-atom structure ensembles of islet amyloid polypeptides determined by enhanced sampling and experiment data restraints
期刊论文
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2019, 卷号: 87, 期号: 7, 页码: 541-550
作者:
Su, Xinyue
;
Wang, Ke
;
Liu, Na
;
Chen, Jiawen
;
Li, Yong
收藏
  |  
浏览/下载:73/0
  |  
提交时间:2019/10/14
aggregation
chemical shift restraint
islet amylod polypeptide
metadynamics
Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 卷号: 92, 期号: 6, 页码: 1998-2008
作者:
Zhong, Li
;
Liu, Qing
;
Ting, Yan Sie
;
Vun Yien Thien
;
Kalong, Nurwafa Syafiqah Binti
收藏
  |  
浏览/下载:89/0
  |  
提交时间:2019/01/08
adenine derivative
structural optimization
thioredoxin-binding protein-2
thioredoxin-interacting protein
vitamin D3-upregulated protein-1
Dual effect of peg-pe micelle over the oligomerization and fibrillation of human islet amyloid polypeptide
期刊论文
Scientific reports, 2018, 卷号: 8, 页码: 12
作者:
Fang, Xiaocui
;
Yousaf, Maryam
;
Huang, Qunxing
;
Yang, Yanlian
;
Wang, Chen
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2019/04/23
The Inhibitory Effect of Hydroxylated Carbon Nanotubes on the Aggregation of Human Islet Amyloid Polypeptide Revealed by a Combined Computational and Experimental Study
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 11
作者:
Mo, Yuxiang
;
Brahmachari, Sayanti
;
Lei, Jiangtao
;
Gilead, Sharon
;
Tang, Yiming
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/05
protein aggregation
human islet amyloid polypeptide
hydroxylated carbon nanotubes
inhibitory mechanism
replica exchange molecular dynamics simulations
TEM experiment
Replica Exchange Molecular Dynamics: A Practical Application Protocol with Solutions to Common Problems and a Peptide Aggregation and Self-Assembly Example.
期刊论文
Methods in molecular biology (Clifton, N.J.), 2018, 卷号: 1777
作者:
Qi Ruxi
;
Wei Guanghong
;
Ma Buyong
;
Nussinov Ruth
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/05
Free energy landscape
GROMACS
Human islet amyloid polypeptide
Molecular dynamics simulations
Protein aggregation
REMD
Replica exchange method
Recent computational studies of membrane interaction and disruption of human islet amyloid polypeptide: Monomers, oligomers and protofibrils
期刊论文
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2018, 卷号: 1860, 期号: 9
作者:
Dong, Xuewei
;
Qiao, Qin
;
Qian, Zhenyu
;
Wei, Guanghong
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/05
Human islet amyloid polypeptide
Type 2 diabetes
Amyloid aggregates
Conformational ensemble
Membrane disruption
Molecular dynamics simulations
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