Bio-inspired amyloid polypeptides: From self-assembly to nanostructure design and biotechnological applications

doi:10.1016/j.apmt.2021.100966

	Bio-inspired amyloid polypeptides: From self-assembly to nanostructure design and biotechnological applications
	Lai, Yi 1; Li, Fenglin 1; Zou, Zhifeng 1; Saeed, Madiha 2; Xu, Zhiai 1; Yu, Haijun 2
刊名	APPLIED MATERIALS TODAY
	2021-03-01
卷号	22 页码:23
关键词	Amyloid polypeptide Bio-inspired Nanomedicine Self-assembly
ISSN号	2352-9407
DOI	10.1016/j.apmt.2021.100966
通讯作者	Xu, Zhiai(zaxu@chem.ecnu.edu.cn) ; Yu, Haijun(hjyu@simm.ac.cn)
英文摘要	The aggregation of amyloid polypeptide plays a crucial role in inducing various chronic diseases, such as neurodegenerative diseases and type II diabetes. Up to date, amyloid polypeptide-based nanostructures have been extensively investigated for various biotechnological applications while exploiting the pathogenic mechanism of amyloid polypeptide-related diseases. Despite extensive and significant progress having been made, the fundamental understanding and the strategies to organize amyloid polypeptide nanomaterials remain elusive. Herein, the blooming developments of bio-inspired self assembled amyloid polypeptide nanostructures on synthesis, properties and applications are mainly introduced. We begin with an emphasis of the importance of thermodynamic and kinetic factors on the self-assembly. Second, the cutting-edge advances and challenges for engineering of amyloid peptide based nanomaterials on multiple dimensions are summarized. Finally, the comprehensive applications in biosensing, bioimaging, drug/gene delivery, cellular scaffolds and air pollution governance of amyloid polypeptide-based nanomaterials are presented. Through summarizing these aspects of amyloid polypeptides, this review is expected to motivate researchers to devote more efforts to investigating of novel architectures and translating the artificial designs for intriguing applications. ? 2021 Elsevier Ltd. All rights reserved.
资助项目	National Natural Science Foundation of China[22074043] ; National Natural Science Foundation of China[21775046] ; Fundamental Research Funds for the Central Universities
WOS研究方向	Materials Science
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000632615400009
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295321]
专题	中国科学院上海药物研究所
通讯作者	Xu, Zhiai; Yu, Haijun
作者单位	1.East China Normal Univ, Sch Chem & Mol Engn, Shanghai 200241, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med SIMM, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Lai, Yi,Li, Fenglin,Zou, Zhifeng,et al. Bio-inspired amyloid polypeptides: From self-assembly to nanostructure design and biotechnological applications[J]. APPLIED MATERIALS TODAY,2021,22:23.
APA	Lai, Yi,Li, Fenglin,Zou, Zhifeng,Saeed, Madiha,Xu, Zhiai,&Yu, Haijun.(2021).Bio-inspired amyloid polypeptides: From self-assembly to nanostructure design and biotechnological applications.APPLIED MATERIALS TODAY,22,23.
MLA	Lai, Yi,et al."Bio-inspired amyloid polypeptides: From self-assembly to nanostructure design and biotechnological applications".APPLIED MATERIALS TODAY 22(2021):23.