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北京大学 [2]
兰州大学 [2]
复旦大学上海医学院 [2]
南华大学 [1]
厦门大学 [1]
中南大学 [1]
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期刊论文 [12]
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2016 [1]
2015 [2]
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cell biolo... [1]
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Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance
期刊论文
European Journal of Medicinal Chemistry, 2017, 卷号: 135, 页码: 34-48
作者:
Zha, Gao-Feng
;
Qin, Hua-Li*
;
Youssif, Bahaa G. M.
;
Amjad, Muhammad Wahab
;
Raja, Maria Abdul Ghafoor
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/04
Epidermal growth factor receptor (EGFR)
BRAF
Focal adhesion kinase (FAK)
Tubulin polymerization
Cancer cell lines
MDR
multidrug resistance
EGFR
epidermal growth factor receptor
EMEA
European Medicines Evaluation Agency
FDA
US Food and Drug Administration
NSCLC
non-small cell lung
FAK
focal adhesion kinase
RTK
receptor tyrosine kinases
MAPK
mitogen-activated protein kinase
ABC
ATP-binding cassette
NF-kB
NF-kappaB
FERM
Four-point-one, ezrin, radixin, moesin
TMP
Ligustrazine or tetramethylpyrazine
Adr
Adriamycin
DRS
death receptors
TFN
tumor necrosis factor
PI
propidium iodide
TKIs
tyrosine kinase inhibitors
FAR
fluorescence activity ratio
HRMS
high resolution mass spectra
TLC
thin layer chromatography
UV
ultraviolet
DMEM
Dulbecco's modified Eagle's medium
DMSO
dimethyl sulfoxide
IBX
2-iodoxybenzoic acid
PTK2-mediated degradation of ATG3 impedes cancer cells susceptible to DNA damage treatment
期刊论文
AUTOPHAGY, 2017
Ma, Ke
;
Fu, Wan
;
Tang, Ming
;
Zhang, Chaohua
;
Hou, Tianyun
;
Li, Ran
;
Lu, Xiaopeng
;
Wang, Yanan
;
Zhou, Jingyi
;
Li, Xue
;
Zhang, Luyao
;
Wang, Lina
;
Zhao, Ying
;
Zhu, Wei-Guo
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2017/12/03
ATG3
cancer therapy
mitotic catastrophe
PTK2
tyrosine phosphorylation
FOCAL ADHESION KINASE
MITOTIC CATASTROPHE
AUTOPHAGOSOME FORMATION
OVARIAN-CANCER
TUMOR-GROWTH
FAK
CONJUGATION
CARCINOMA
PATHWAYS
DEATH
Inhibition of osteopontin reduce the cardiac myofibrosis in dilated cardiomyopathy via focal adhesion kinase mediated signaling pathway
期刊论文
2016, 卷号: 8, 期号: 9, 页码: 3645-3655
作者:
Zhao, Hui
;
Wang, Wei
;
Zhang, Jie
;
Liang, Tuo
;
Fan, Guang-Pu
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/04
Osteopontin (OPN)
Focal Adhesion Kinase (FAK)
cardiac fibrosis
dilated cardiomyopathy (DCM)
fibroblast
PTEN inhibits macrophage polarization from M1 to M2 through CCL2 and VEGF-A reduction and NHERF-1 synergism.
期刊论文
Cancer Biology and Therapy, 2015, 卷号: Vol.16 No.2, 页码: 297-306
作者:
Ning Li
;
Junfang Qin
;
Lan Lan
;
Hongyao Zhang
;
Fang Liu
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/02/27
CAFs, cancer associated fibroblasts
CCL2
CM, complete medium
CXCL, the chemokine (C-X-C motif) ligand
CXCR3, Chemokine (C-X-C motif) receptor 3
FAK, focal adhesion kinase
NHERF-1
NHERF-1, Na+/H+ exchanger regulating factor1
PTEN
PTEN, phosphatase and tensin homolog deletedon chromosome 10
SCC, squamous cell carcinoma
TAM
TAMs, tumor-associated macrophages
TSN, tumor culture supernatant
co-culture
transformation
MicroRNAs in osteosarcoma
期刊论文
Clinica Chimica Acta, 2015, 卷号: 444, 页码: 9-17
作者:
Zhang, Jian
;
Yan, Yi-Guo
;
Wang, Cheng
;
Zhang, Shu-Jun
;
Yu, Xiao-Hua*
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2019/12/27
OS
osteosarcoma
miRNAs
microRNAs
CSCs
cancer stem cells
RNA pol
RNA polymerase
DGCR8
DiGeorge syndrome critical gene 8
RISC
RNA-induced silencing complex
Exp 5
exportin 5
Ago
argonaute
MREs
miRNA recognition elements
APE1
apurinic/apyrimidinic endonuclease 1
MDM
murine double minute
TP53
tumor suppressor p53
mTOR
mammalian target of rapamycin
Eag1
ether à go-go 1
PI3K
phosphatidylinositol-3-kinase
PTEN
phosphatase and tensin homolog deleted on chromosome ten
Hsp90B1
heat shock protein 90B1
BMP2
bone morphogenetic protein 2
IGF1R
insulin-like growth factor 1 receptor
FAK
phospho-Akt and focal adhesion kinase
LPAATβ
lysophosphatidic acid acyltransferase β
HMGB1
high-mobility group box 1
FASN
fatty acid synthase
LZTS1
leucine zipper putative tumor suppressor 1
MMP
matrix metalloproteinase
LNA
locked nucleic acid
DATS
diallyl trisulfide
miRNAs
OS
TP53
Notch
Chemoresistance
The role of integrin-beta/FAK in cyclic mechanical stimulation in MG-63 cells.
期刊论文
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2014, 卷号: 7, 期号: 11, 页码: 7451-7459
作者:
Yang, Min
;
Xiao, Li-Wei*
;
Liao, Er-Yuan
;
Wang, Qiao-Jing
;
Wang, Bei-Bei
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
ERK signal pathway
Integrin-beta
focal adhesion kinase (FAK)
human osteosarcoma MG63 cells
mechanical stimulation
Trans-3,4,5,4 '-tetramethoxystilbene, a resveratrol analog, potently inhibits angiogenesis in vitro and in vivo
期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 9
作者:
Chen, LK
;
Qiang, PF
;
Xu, QP
;
Zhao, YH
;
Dai, F
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2014/12/05
angiogenesis
trans-3,4,5,4 '-tetramethoxystilbene
resveratrol
endothelial cell
VEGF
VEGF receptor 2
c-Src
Erk1/2
Akt
mTOR
focal adhesion kinase (FAK)
ribosomal protein S6 kinase (p70S6K)
Cytoskeletal reorganization mediates fluid shear stress-induced ERK5 activation in osteoblastic cells
期刊论文
CELL BIOLOGY INTERNATIONAL, 2012, 卷号: 36, 期号: 3, 页码: 229-236
作者:
Li, P
;
Ma, YC
;
Shen, HL
;
Han, H
;
Wang, J
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2016/03/29
cytoskeleton
extracellular-signal-regulated kinase 5 (ERK5)
focal adhesion kinase (FAK)
fluid shear stress
reorganization
Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP beta/zeta signaling by menin
期刊论文
http://dx.doi.org/10.1038/onc.2010.282, 2010
Feng, Z-J
;
Gao, S-B
;
Wu, Y.
;
Xu, X-F
;
Hua, X.
;
Jin, G-H
;
金光辉
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2015/07/22
FOCAL-ADHESION KINASE
TYROSINE-PHOSPHATASE BETA/ZETA
UP-REGULATION
GENE
PLEIOTROPHIN
INTEGRIN
FAK
METASTASIS
INVASION
PATHWAY
FAAP, a novel murine protein, is involved in cell adhesion through regulating vinculin-paxillin association
期刊论文
frontiers in bioscience landmark, 2008
Hu, Jinsong
;
Teng, Junlin
;
Ding, Naizheng
;
He, Mei
;
Sun, Yuhui
;
Yu, Albert Cheung Hoi
;
Chen, Jianguo
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2015/11/16
D10Wsu52e gene
FAAP
cell adhesion
vinculin
paxillin
FAK
FOCAL ADHESIONS
KINASE
MATRIX
PHOSPHORYLATION
EXPRESSION
MIGRATION
SRC
LOCALIZATION
APOPTOSIS
DYNAMICS
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