Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP beta/zeta signaling by menin

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	Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP beta/zeta signaling by menin
	Feng, Z-J ; Gao, S-B ; Wu, Y. ; Xu, X-F ; Hua, X. ; Jin, G-H ; Jin GH(金光辉)
刊名	http://dx.doi.org/10.1038/onc.2010.282
	2010-09
关键词	FOCAL-ADHESION KINASE TYROSINE-PHOSPHATASE BETA/ZETA UP-REGULATION GENE PLEIOTROPHIN INTEGRIN FAK METASTASIS INVASION PATHWAY
英文摘要	NFSC [30701003]; National Cancer Institute [R01CA113962]; Menin encoded by the multiple endocrine neoplasia type 1 (MEN1) gene is associated with chromatin and the nuclear matrix and exerts multiple biological functions including regulation of cell proliferation and adhesion. Men1 mutations increase the likelihood of lung cancer development in mice. Menin expression is reduced in certain human non-small cell lung cancer cells, and reduction of menin is closely correlated with increased lung cancer metastasis to lymph nodes. However, it is poorly understood whether menin affects migration of lung cancer cells. In this study, we show that meninregulated A549 lung cancer cell migration, which was mediated by growth factor pleiotrophin (PTN) and its cell surface receptor, protein tyrosine phosphatase beta/zeta (RPTP beta/zeta). Ectopic menin expression significantly repressed PTN transcription, but indirectly inhibited RPTP beta/zeta expression through repressing PTN expression. Further studies revealed that menin-regulated cell migration through PTN/RPTP beta/zeta, in conjunction with integrin alpha(v)beta(3), focal adhesion kinase, phosphatidylinositol 3-kinase and phosphorylated extracellular signal regulated kinase 1/2. These findings provide mechanistic insights into the molecular basis for menin/PTN-mediated regulation of A549 lung cancer cell migration. Oncogene (2010) 29, 5416-5426; doi: 10.1038/onc.2010.282; published online 19 July 2010
语种	英语
出版者	ONCOGENE
内容类型	期刊论文
源URL	[http://dspace.xmu.edu.cn/handle/2288/93175]
专题	医学院－已发表论文
推荐引用方式 GB/T 7714	Feng, Z-J,Gao, S-B,Wu, Y.,et al. Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP beta/zeta signaling by menin[J]. http://dx.doi.org/10.1038/onc.2010.282,2010.
APA	Feng, Z-J.,Gao, S-B.,Wu, Y..,Xu, X-F.,Hua, X..,...&金光辉.(2010).Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP beta/zeta signaling by menin.http://dx.doi.org/10.1038/onc.2010.282.
MLA	Feng, Z-J,et al."Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP beta/zeta signaling by menin".http://dx.doi.org/10.1038/onc.2010.282 (2010).