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科研机构
上海药物研究所 [208]
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期刊论文 [205]
会议论文 [2]
学位论文 [1]
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2021 [9]
2020 [9]
2019 [19]
2018 [18]
2017 [14]
2016 [12]
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Discovery of a subtype-selective, covalent inhibitor against palmitoylation pocket of TEAD3
期刊论文
ACTA PHARMACEUTICA SINICA B, 2021, 卷号: 11, 期号: 10, 页码: 3206-3219
作者:
Lu, Tian
;
Li, Yong
;
Lu, Wenchao
;
Spitters, Twgm
;
Fang, Xueyu
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/12/01
Hippo pathway
TEAD3
Covalent inhibitor
Palmitoylation inhibitor
Global identification of phospho-dependent SCF substrates reveals a FBXO22 phosphodegron and an ERK-FBXO22-BAG3 axis in tumorigenesis
期刊论文
CELL DEATH AND DIFFERENTIATION, 2021, 页码: 13
作者:
Liu, Ping
;
Cong, Xiaoji
;
Liao, Shengjie
;
Jia, Xinglong
;
Wang, Xiaomin
收藏
  |  
浏览/下载:81/0
  |  
提交时间:2021/08/17
DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation
期刊论文
DIABETES, 2021, 卷号: 70, 期号: 6, 页码: 1317-1333
作者:
Shuai, Lin
;
Li, Bo-Han
;
Jiang, Hao-Wen
;
Yang, Lin
;
Li, Jia
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2021/08/17
ZEB1 Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation Partly via Wnt/beta-Catenin Signaling
期刊论文
FRONTIERS IN MOLECULAR BIOSCIENCES, 2021, 卷号: 8, 页码: 11
作者:
Xu, Cuidi
;
Shi, Hongli
;
Jiang, Xin
;
Fan, Yongqian
;
Huang, Donghui
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/08/17
ZEB1
osteogenesis
Wnt/beta-catenin
postmenopausal osteoporosis
BMSCs
Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 215, 页码: 13
作者:
Gao, Feng
;
Chen, Xiaoxu
;
Lu, Junyan
;
Hu, Shulei
;
Xu, Hui
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2021/05/24
Ceramide analogs
AKT inhibitor
MK2206
Colon cancer
Combination therapy
9,10-Anhydrodehydroartemisinin Attenuates Experimental Autoimmune Encephalomyelitis by Inhibiting Th1 and Th17 Cell Differentiation
期刊论文
INFLAMMATION, 2021, 页码: 10
作者:
Lv, Jie
;
Zhuang, Wei
;
Zhang, Yan
;
Xie, Ling
;
Xiang, Zhenglong
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2021/05/24
9
10-Anhydrodehydroartemisinin
artemisinin
multiple sclerosis
Th1
Th17
experimental autoimmune encephalomyelitis
Cephalodiones A-D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition
期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 页码: 6
作者:
Ge, Zhan-Peng
;
Fan, Yao-Yue
;
Deng, Wen-De
;
Zheng, Cheng-Yu
;
Li, Ting
收藏
  |  
浏览/下载:75/0
  |  
提交时间:2021/05/24
[6+6]-cycloaddition
C-19-norditerpenoid dimers
natural products
semisynthesis
Th17 cell differentiation
A novel tricyclic BTK inhibitor suppresses B cell responses and osteoclastic bone erosion in rheumatoid arthritis
期刊论文
ACTA PHARMACOLOGICA SINICA, 2021, 页码: 12
作者:
Liu, Yu-ting
;
Ding, Hui-hua
;
Lin, Ze-min
;
Wang, Que
;
Chen, Li
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2021/05/24
rheumatoid arthritis
BTK inhibitors
B cells
macrophages
RANKL
osteoclastogenesis
CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis
期刊论文
THERANOSTICS, 2021, 卷号: 11, 期号: 20, 页码: 9821-9832
作者:
Li, Xiaoxun
;
Liang, Yajun
;
Lian, Cheng
;
Peng, Fangli
;
Xiao, Yansen
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2022/01/04
Breast cancer
Bone metastasis
Osteoclastogenesis
CST6
Peptide drug
Diphyllin Improves High-Fat Diet-Induced Obesity in Mice Through Brown and Beige Adipocytes
期刊论文
FRONTIERS IN ENDOCRINOLOGY, 2020, 卷号: 11, 页码: 13
作者:
Duan, Ya-Nan
;
Ge, Xiang
;
Jiang, Hao-Wen
;
Zhang, Hong-Jie
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2021/05/24
diphyllin
obesity
brown adipocyte
differentiation
thermogenesis
V-ATPase
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