ZEB1 Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation Partly via Wnt/beta-Catenin Signaling

doi:10.3389/fmolb.2021.682728

	ZEB1 Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation Partly via Wnt/beta-Catenin Signaling
	Xu, Cuidi 1; Shi, Hongli 1; Jiang, Xin 1; Fan, Yongqian 2; Huang, Donghui 2; Qi, Xinming 3; Cheng, Qun 1
刊名	FRONTIERS IN MOLECULAR BIOSCIENCES
	2021-05-24
卷号	8 页码:11
关键词	ZEB1 osteogenesis Wnt/beta-catenin postmenopausal osteoporosis BMSCs
DOI	10.3389/fmolb.2021.682728
通讯作者	Qi, Xinming(xmqi@cdser.simm.ac.cn) ; Cheng, Qun(chengqun@fudan.edu.cn)
英文摘要	Zinc finger E-box-binding homebox 1 (ZEB1) is a zinc-finger transcription factor best known for its role in promoting the epithelial-mesenchymal transition, which is also related to osteogenesis. Here, ZEB1 was investigated for its role in the commitment of bone marrow mesenchymal stem cells (BMSCs) to osteoblasts. In vitro, ZEB1 expression decreased following osteogenic differentiation. Furthermore, silencing of ZEB1 in BMSCs promoted osteogenic activity and mineralization. The increase in osteogenic differentiation induced by si-ZEB1 could be partly rescued by the inhibition of Wnt/beta-catenin (si-beta-catenin). In vivo, knockdown of ZEB1 in BMSCs inhibited the rapid bone loss of ovariectomized (OVX) mice. ZEB1 expression has also been negatively associated with bone mass and bone formation in postmenopausal women. In conclusion, ZEB1 is an essential transcription factor in BMSC differentiation and may serve as a potential anabolic strategy for treating and preventing postmenopausal osteoporosis (PMOP).
资助项目	National Natural Science Foundation of China (NSFC)[81471089] ; National Key R&D Program of China[2018YFC2000201]
WOS关键词	DELTA-EF1 ; REPRESSES ; EXPRESSION ; LOOP
WOS研究方向	Biochemistry & Molecular Biology
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000658430100001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/297053]
专题	中国科学院上海药物研究所
通讯作者	Qi, Xinming; Cheng, Qun
作者单位	1.Fudan Univ, Shanghai Geriatr Inst, Res Sect Geriatr Metab Bone Dis, Dept Osteoporosis & Bone Dis,Huadong Hosp, Shanghai, Peoples R China 2.Fudan Univ, Huadong Hosp, Dept Orthoped, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Drug Safety Evaluat & Res, State Key Lab Drug Res, Shanghai, Peoples R China
推荐引用方式 GB/T 7714	Xu, Cuidi,Shi, Hongli,Jiang, Xin,et al. ZEB1 Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation Partly via Wnt/beta-Catenin Signaling[J]. FRONTIERS IN MOLECULAR BIOSCIENCES,2021,8:11.
APA	Xu, Cuidi.,Shi, Hongli.,Jiang, Xin.,Fan, Yongqian.,Huang, Donghui.,...&Cheng, Qun.(2021).ZEB1 Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation Partly via Wnt/beta-Catenin Signaling.FRONTIERS IN MOLECULAR BIOSCIENCES,8,11.
MLA	Xu, Cuidi,et al."ZEB1 Mediates Bone Marrow Mesenchymal Stem Cell Osteogenic Differentiation Partly via Wnt/beta-Catenin Signaling".FRONTIERS IN MOLECULAR BIOSCIENCES 8(2021):11.