Cephalodiones A-D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition

doi:10.1002/anie.202015332

	Cephalodiones A-D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition
	Ge, Zhan-Peng 1; Fan, Yao-Yue 1; Deng, Wen-De 2; Zheng, Cheng-Yu 1; Li, Ting 2; Yue, Jian-Min 1
刊名	ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
	2021-03-10
页码	6
关键词	[6+6]-cycloaddition C-19-norditerpenoid dimers natural products semisynthesis Th17 cell differentiation
ISSN号	1433-7851
DOI	10.1002/anie.202015332
通讯作者	Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要	Cephalodiones A-D (1-4), the first example of C-19-norditerpenoid dimers, were isolated and fully characterized from a Cephalotaxus plant. These new skeletal natural products shared a unique tricyclo[6.4.1.1(2,7)]tetradeca-3,5,9,11-tetraene-13,14-dione core that was capped in both ends with rigid multicyclic ring systems either C-2-symmetrically or asymmetrically. Compounds 1-4 were proposed to be biosynthetically produced by the [6+6]-cycloaddition of two identical C-19-norditerpenoid troponoids, which was validated by the semisyntheses of dimers 2-4. Moreover, some compounds showed significant inhibition on Th17 cell differentiation.
资助项目	National Natural Science Foundation of the People's Republic of China[81872758] ; National Natural Science Foundation of the People's Republic of China[21532007] ; National Natural Science Foundation of the People's Republic of China[21772213] ; Medical and Health Science and Technology Innovation Project of CAMS[2019-I2M-5-080] ; Biological Resources Program of CAS[ZSTH-032]
WOS研究方向	Chemistry
语种	英语
出版者	WILEY-V C H VERLAG GMBH
WOS记录号	WOS:000627043400001
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/295788]
专题	中国科学院上海药物研究所
通讯作者	Yue, Jian-Min
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Macau Univ Sci & Technol, Macau Inst Appl Res Med & Hlth, State Key Lab Qual Res Chinese Med, Ave Wai Long, Taipa 999078, Macau, Peoples R China
推荐引用方式 GB/T 7714	Ge, Zhan-Peng,Fan, Yao-Yue,Deng, Wen-De,et al. Cephalodiones A-D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2021:6.
APA	Ge, Zhan-Peng,Fan, Yao-Yue,Deng, Wen-De,Zheng, Cheng-Yu,Li, Ting,&Yue, Jian-Min.(2021).Cephalodiones A-D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,6.
MLA	Ge, Zhan-Peng,et al."Cephalodiones A-D: Compound Characterization and Semisynthesis by [6+6] Cycloaddition".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021):6.