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上海药物研究所 [28]
山东大学 [23]
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期刊论文 [190]
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2019 [190]
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发表日期:2019
内容类型:期刊论文
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Raptor/mTORC1 Acts as a Modulatory Center to Regulate Anti-bacterial Immune Response in Rockfish
期刊论文
FRONTIERS IN IMMUNOLOGY, 2019, 卷号: 10, 页码: 14
作者:
Li, Kang
;
Wei, Xiumei
;
Zhang, Libin
;
Chi, Heng
;
Yang, Jialong
收藏
  |  
浏览/下载:139/0
  |  
提交时间:2020/03/20
teleost
mTORC1
raptor
lymphocyte
immune regulation
evolution
Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 184, 页码: 15
作者:
Lu, Wenchao
;
Wang, Jun
;
Li, Yong
;
Tao, Hongru
;
Xiong, Huan
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2020/07/01
Hippo pathway
TEAD transcription factor
Covalent inhibitor
Palmitoylation inhibitor
Discovery of a novel protein kinase C activator from Croton tiglium for inhibition of non-small cell lung cancer
期刊论文
PHYTOMEDICINE, 2019, 卷号: 65, 页码: 11
作者:
Wang Yuwei
;
Tang Chunping
;
Yao Sheng
;
Lai Huanling
;
Li Runze
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  |  
浏览/下载:40/0
  |  
提交时间:2020/07/01
Non-small cell lung cancer
Natural product
Croton tiglium
Protein kinase C
Molecular modelling
Design, synthesis, and biological evaluation of thieno[3,2-d]pyrimidine derivatives as potential simplified phosphatidylinositol 3-kinase alpha inhibitors
期刊论文
CHEMICAL BIOLOGY & DRUG DESIGN, 2019, 卷号: 94, 期号: 6, 页码: 2013-2022
作者:
Yang, Xiuyan
;
Deng, Meng
;
Zhang, Xi
;
Wang, Yi
;
Song, Kun
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  |  
浏览/下载:78/0
  |  
提交时间:2020/07/01
PI3K alpha inhibitors
proliferation inhibition
thieno[3
2-d]pyrimidine derivatives
3-Deoxy-2 beta,16-dihydroxynagilactone E, a natural compound from Podocarpus nagi, preferentially inhibits JAK2/STAT3 signaling by allosterically interacting with the regulatory domain of JAK2 and induces apoptosis of cancer cells
期刊论文
ACTA PHARMACOLOGICA SINICA, 2019, 卷号: 40, 期号: 12, 页码: 1578-1586
作者:
Shan, Hui
;
Yao, Sheng
;
Ye, Yang
;
Yu, Qiang
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  |  
浏览/下载:10/0
  |  
提交时间:2020/07/01
JAK/STAT
3-deoxy-2 beta,16-dihydroxynagilactone E
tyrosine kinase inhibitor
allosteric inhibitor
cancer
PI signal transduction and ubiquitination respond to dehydration stress in the red seaweed Gloiopeltis furcata under successive tidal cycles
期刊论文
BMC PLANT BIOLOGY, 2019, 卷号: 19, 期号: 1, 页码: 14
作者:
Liu, Shun
;
Hu, Zi-Min
;
Zhang, Quansheng
;
Yang, Xiaoqi
;
Critchley, Alan T.
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  |  
浏览/下载:77/0
  |  
提交时间:2020/03/20
Seaweed
Dehydration
Ubiquitination
Phosphatidylinositol signaling system
Weighted gene co-expression network analysis
Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling
期刊论文
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2019, 卷号: 183, 页码: -
作者:
Liang, Shaojun
;
Liang, Shengxian
;
Zhou, Hui
;
Yin, Nuoya
;
Faiola, Francesco
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  |  
浏览/下载:24/0
  |  
提交时间:2020/09/10
Human neural stem cells (hNSCs)
TBBPA/TBBPS/TCBPA
BDE-209/BDE-47
Human neural developmental toxicity
GSK3 beta
T3 signaling
Isoflurane produces antidepressant effects inducing BDNF-TrkB signaling in CUMS mice
期刊论文
PSYCHOPHARMACOLOGY, 2019, 卷号: 236, 期号: 11, 页码: 3301-3315
作者:
Zhang, Sha-Sha
;
Tian, Yu-Hua
;
Jin, Song-Jun
;
Wang, Wen-Cheng
;
Zhao, Jing-Xin
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2020/09/21
Isoflurane
Rapid antidepressant activity
Chronic unpredictable mild stressed
Brain-derived neurotrophic factor
Tropomyosin receptor kinase B
Dendritic spine density
PD-L1 expression levels on tumor cells affect their immunosuppressive activity
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 5, 页码: 5399-5407
作者:
Zheng, Yang
;
Fang, You-Chen
;
Li, Jing
收藏
  |  
浏览/下载:55/0
  |  
提交时间:2020/07/01
programmed cell death 1
programmed death-ligand 1
co-culture
immunosuppression
signaling pathway
fDiscovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 180, 页码: 72-85
作者:
Zhan, Wenhu
;
Che, Jinxin
;
Xu, Lei
;
Wu, Yizhe
;
Hu, Xiaobei
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  |  
浏览/下载:17/0
  |  
提交时间:2020/07/01
Pyrazole-thiophene derivatives
Akt inhibitor
Antitumor
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