Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling
	Liang, Shaojun 1; Liang, Shengxian 1; Zhou, Hui 1; Yin, Nuoya 1; Faiola, Francesco 1
刊名	ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
	2019-11-15
卷号	183 页码:-
关键词	Human neural stem cells (hNSCs) TBBPA/TBBPS/TCBPA BDE-209/BDE-47 Human neural developmental toxicity GSK3 beta T3 signaling
ISSN号	0147-6513
英文摘要	2',2',4,4'-tetrabromo diphenyl ether (BDE-47), one of the most abundant congeners of commercial pentaBDE utilized as flame retardants, has been phased out of production due to its potential neural toxicity and endocrine disrupting activities, and yet still present in the environment. Several alternatives to BDE-47, including tetrabromobisphenol A (TBBPA), tetrabromobisphenol S (TBBPS), tetrachlorobisphenol A (TCBPA) and decabromodiphenyl ether (BDE-209), are presently employed without restrictions and their potential toxic effects on human neural development are still unclear. In this study, we utilized a human neural stem cell (hNSC)-based system to evaluate the potential developmental neurotoxic effects of the above-mentioned five chemicals, at environment and human exposure relevant concentrations. We found that those compounds slightly altered the expression of hNSC identity markers (SOX2, SOX3 and NES), without impairing cell viability or proliferation, in part by either modulating glycogen synthase kinase 3 beta (GSK beta) signaling (TBBPS, TCBPA and BDE-47), and slightly disturbing the NOTCH pathway (TBBPA, TBBPS and TCBPA). Moreover, the five chemicals seemed to alter hNSC differentiation by perturbing triiodothyronine (T3) cellular signaling. Thus, our findings suggest that the five compounds, especially TBBPS, TCBPA, and BDE-47, may affect hNSC self-renewal and differentiation abilities and potentially elicit neural developmental toxicity.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/42611]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
作者单位	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Liang, Shaojun,Liang, Shengxian,Zhou, Hui,et al. Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2019,183:-.
APA	Liang, Shaojun,Liang, Shengxian,Zhou, Hui,Yin, Nuoya,&Faiola, Francesco.(2019).Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,183,-.
MLA	Liang, Shaojun,et al."Typical halogenated flame retardants affect human neural stem cell gene expression during proliferation and differentiation via glycogen synthase kinase 3 beta and T3 signaling".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 183(2019):-.