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浏览/检索结果: 共9条，第1-9条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Development of small-molecule immune checkpoint inhibitors of PD-1/PD-L1 as a new therapeutic strategy for tumour immunotherapy 期刊论文 2019, 卷号: 27, 期号: 3, 页码: 244-256 作者:  Li, Kui;  Tian, Hongqi 收藏  |  浏览/下载：11/0  |  提交时间：2020/01/03 Small-molecule inhibitors  PD-1  PD-L1 immune checkpoint  targeted therapy  tumour immunotherapy  clinical and preclinical research   Construction and application of service quality evaluation system in the preclinical research on cardiovascular implant devices 期刊论文 2019, 卷号: 19, 期号: 1, 页码: 37 作者:  Cui, Yongchun;  Luo, Fuliang;  Yang, Boqing;  Li, Bin;  Zhang, Qi 收藏  |  浏览/下载：8/0  |  提交时间：2020/01/03 Fuzzy analytical hierarchy process  Cardiovascular implant devices  Preclinical research and development service  Quality evaluation system   Image correction for diffusion tensor imaging of Rhesus monkey thoracic spinal cord 期刊论文 Journal of medical primatology, 2019, 卷号: 48, 页码: 320-328 作者:  Rao Jia-Sheng;  Liu Zuxiang;  Zhao Can;  Wei Rui-Han;  Liu Ruo-Xi 收藏  |  浏览/下载：10/0  |  提交时间：2019/12/30 image correction strategy  non-human primates  preclinical research  spinal cord injury   Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis? 期刊论文 HUMAN REPRODUCTION UPDATE, 2018, 卷号: 24, 期号: 5 作者:  Guo, Sun-Wei;  Groothuis, Patrick G. 收藏  |  浏览/下载：8/0  |  提交时间：2019/12/05 adenomyosis  clinical trial  drug research and development  endometriosis  innovation drought  pathophysiology  preclinical studies  transparency   Drug discovery and drug marketing with the critical roles of modern administration. 期刊论文 American journal of translational research, 2018, 卷号: Vol.10 No.12, 页码: 4302-4312 作者:  Jing Chen;  Xiaofang Luo;  Huimin Qiu;  Vienna Mackey;  Lichun Sun 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/26 Drug research and development  administration  laboratory  management  preclinical and clinical trial   Drug discovery and drug marketing with the critical roles of modern administration 期刊论文 AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2018, 卷号: Vol.10 No.12, 页码: 4302-4312 作者:  Chen, J;  Luo, XF;  Qiu, HM;  Mackey, V;  Sun, LC 收藏  |  浏览/下载：1/0  |  提交时间：2019/12/26 Drug research and development  laboratory  preclinical and clinical trial  administration  management   Drug discovery and drug marketing with the critical roles of modern administration 期刊论文 AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2018, 卷号: Vol.10 No.12, 页码: 4302-4312 作者:  Chen, J;  Luo, XF;  Qiu, HM;  Mackey, V;  Sun, LC 收藏  |  浏览/下载：2/0  |  提交时间：2019/12/26 Drug research and development  laboratory  preclinical and clinical trial  administration  management   Drug discovery and drug marketing with the critical roles of modern administration. 期刊论文 American journal of translational research, 2018, 卷号: Vol.10 No.12, 页码: 4302-4312 作者:  Jing Chen;  Xiaofang Luo;  Huimin Qiu;  Vienna Mackey;  Lichun Sun 收藏  |  浏览/下载：4/0  |  提交时间：2019/12/26 Drug  research  and  development  administration  laboratory  management  preclinical  and  clinical  trial   Profile of minocycline and its potential in the treatment of schizophrenia 期刊论文 Neuropsychiatric Disease and Treatment, 2014, 卷号: 10, 页码: 1103-1111 作者:  Zhang, Lulu;  Zhao, Jingping* 收藏  |  浏览/下载：3/0  |  提交时间：2019/12/03 Accumulating evidence suggests that neuroinflammation affecting microglia plays an important role in the etiology of schizophrenia  and appropriate control of microglial activation may be a promising therapeutic strategy for schizophrenia. Minocycline  a second-generation tetracycline that inhibits microglial activation  has been shown to have a neuroprotective effect in various models of neurodegenerative disease  including anti-inflammatory  antioxidant  and antiapoptotic properties  and an ability to modulate glutamate-induced excitotoxicity. Given that these mechanisms overlap with neuropathologic pathways  minocycline may have a potential role in the adjuvant treatment of schizophrenia  and improve its negative symptoms. Here  we review the relevant studies of minocycline  ranging from preclinical research to human clinical trials.