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	Profile of minocycline and its potential in the treatment of schizophrenia
	Zhang, Lulu; Zhao, Jingping*
刊名	Neuropsychiatric Disease and Treatment
	2014
卷号	10页码:1103-1111
关键词	Accumulating evidence suggests that neuroinflammation affecting microglia plays an important role in the etiology of schizophrenia and appropriate control of microglial activation may be a promising therapeutic strategy for schizophrenia. Minocycline a second-generation tetracycline that inhibits microglial activation has been shown to have a neuroprotective effect in various models of neurodegenerative disease including anti-inflammatory antioxidant and antiapoptotic properties and an ability to modulate glutamate-induced excitotoxicity. Given that these mechanisms overlap with neuropathologic pathways minocycline may have a potential role in the adjuvant treatment of schizophrenia and improve its negative symptoms. Here we review the relevant studies of minocycline ranging from preclinical research to human clinical trials.
ISSN号	1176-6328
DOI	10.2147/NDT.S64236
URL标识	查看原文
WOS记录号	WOS:000338423700002
内容类型	期刊论文
URI标识	http://www.corc.org.cn/handle/1471x/3322710
专题	中南大学
作者单位	1.[Zhang, Lulu 2.Zhao, Jingping] Cent S Univ, Mental Hlth Inst, Xiangya Hosp 2, Key Lab Psychiat & Mental Hlth Hunan Prov, Changsha 410011, Hunan, Peoples R China.
推荐引用方式 GB/T 7714	Zhang, Lulu,Zhao, Jingping*. Profile of minocycline and its potential in the treatment of schizophrenia[J]. Neuropsychiatric Disease and Treatment,2014,10:1103-1111.
APA	Zhang, Lulu,&Zhao, Jingping*.(2014).Profile of minocycline and its potential in the treatment of schizophrenia.Neuropsychiatric Disease and Treatment,10,1103-1111.
MLA	Zhang, Lulu,et al."Profile of minocycline and its potential in the treatment of schizophrenia".Neuropsychiatric Disease and Treatment 10(2014):1103-1111.

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