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中南大学 [7]
南华大学 [5]
山东大学 [5]
中国医学科学院 北京... [5]
西安交通大学 [4]
复旦大学上海医学院 [4]
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期刊论文 [40]
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Activation of the mammalian target of rapamycin signaling pathway underlies a novel inhibitory role of ring finger protein 182 in ventricular remodeling after myocardial ischemia-reperfusion injury
期刊论文
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 卷号: 120, 期号: 5
作者:
Wei, Zhi-Feng
;
Wang, Jing-Hua
;
Gao, Yan-Li
;
Liu, Cong-Cong
;
Sun, Jing-Hui
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/12/05
gene silencing
mammalian target of rapamycin (mTOR) signaling pathway
myocardial ischemia-reperfusion injury (MIRI)
ring finger protein 182 (RNF182)
ventricular remodeling
Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway
期刊论文
BIOLOGICAL TRACE ELEMENT RESEARCH, 2019, 卷号: 190, 期号: 2, 页码: 327-335
作者:
Zhou, Hongming
;
Jiao, Guangjun
;
Dong, Meng
;
Chi, Hai
;
Wang, Hongliang
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/12/11
Orthosilicic acid
Phosphatidylinositol-4
5-bisphosphate 3-kinase
(PI3K)
Protein kinase B (PKB
Akt)
Mammalian target of rapamycin
(mTOR)
Osteoporosis
Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K–Akt–mTOR Pathway
期刊论文
Biological Trace Element Research, 2018
作者:
Zhou H.
;
Jiao G.
;
Dong M.
;
Chi H.
;
Wang H.
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
Mammalian target of rapamycin (mTOR)
Orthosilicic acid
Osteoporosis
Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)
Protein kinase B (PKB/Akt)
Methyl cinnamate alleviated CCI-induced upregualtion of spinal AMPA receptors and pain hypersensitivity by targeting AMPK
期刊论文
European Journal of Pharmacology, 2018, 卷号: 833, 页码: 183-189
作者:
Gui, Yulong
;
Chen, Liang
;
Duan, Shunyuan
;
Li, Guan
;
Tang, Jing
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/27
AMP-activated protein kinase (AMPK)
L-alpha-amino-3-hydroxy-5-methylisoxazole- 4-propionate receptors (AMPARs)
Methyl cinnamate(MC)
Neuropathic pain
The mammalian target of rapamycin(mTOR)
The preclinical assessment of XL388, a mTOR kinase inhibitor, as a promising anti-renal cell carcinoma agent
期刊论文
ONCOTARGET, 2017, 卷号: 8, 期号: 18
作者:
Xiong, Zuquan
;
Zang, Yiwen
;
Zhong, Shan
;
Zou, Lujia
;
Wu, Yishuo
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/05
renal cell carcinoma (RCC)
mammalian target of rapamycin (mTOR)
apoptosis
XL388
MEK-ERK
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
Combination of metformin with chemotherapeutic drugs via different molecular mechanisms
期刊论文
Cancer Treatment Reviews, 2017, 卷号: 54, 页码: 24-33
作者:
Peng, Mei*
;
Darko, Kwame Oteng
;
Tao, Ting
;
Huang, Yanjun
;
Su, Qiongli
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/12/03
AIs
aromatase inhibitors
AMPK
Adenosine Monophosphate-Activated Protein Kinase
AR
androgen
ATM
Ataxia Telangiectasia Mutated
ATP
Adenosine Triphosphate
BCSS
breast cancer specific survival
CK-MB
Creatine Kinase-MB
CREB1
cAMP Response Element-Binding Protein 1
CSC
cancer stem cell
DFS
disease-free survival
DHFU
dihydrofluorouracil
DPD
dihydropyrimidine dehydrogenase
EpCAM
Epithelial Cell Adhesion Molecule
ER
estrogen
ERCC1
excision repair cross-complementary 1
ERK
extracellular signal-regulated kinases
EZH2
enhancer of zeste homolog 2
FdUMP
fluorodeoxyuridine monophosphate
FdUTP
fluorodeoxyuridine triphosphate
FHC
ferritin heavy chain
FUTP
fluorouridine triphosphate
HbA1C
hemoglobin A1c
HER
Human Epidermal Growth Factor Receptor
HIF-1α
hypoxia-inducible factor-1α
HK
hexokinase
IGF1R
insulin growth factor 1 receptor
LDH
lactate dehydrogenase
MDA
Muscular Dystrophy Association
MMP
Matrix Metallopeptidase
MRP1
multidrug resistance-associated protein 1
mTOR
mammalian target of rapamycin
MTX
methotrexate
NCCN
National Comprehensive Cancer Network
OS
overall survival
pCR
Pathologic Complete Response
PDGFR
platelet-derived growth factor receptors
PFS
progression-free survival
PKA
protein kinase A
PR
progesterone receptor
RFS
relapse-free survival
SOD
superoxide dismutase
TAM
tamoxifen
TCA
tricarboxlic acid
TS
thymidylate synthase
Combination
Mechanisms
Metformin
Chemotherapeutic drugs
Restoration of autophagy by puerarin in lead-exposed primary rat proximal tubular cells via regulating AMPK-mTOR signaling
期刊论文
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2017, 卷号: 31, 期号: 3
作者:
Song, Xiangbin
;
Li, Zifa
;
Liu, Fei
;
Wang, Zhenyong
;
Wang, Lin
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/11
Puerarin
lead
autophagy
5 ' AMP-activated protein kinase (AMPK)
mammalian target of rapamycin (mTOR)
Protective effects of luteolin-7-O-glucoside against starvation-induced injury through upregulation of autophagy in H9c2 Cells
期刊论文
BIOSCIENCE TRENDS, 2017, 卷号: 11, 期号: 5, 页码: 557-564
作者:
Yao, Hong
;
Zhou, Lichun
;
Tang, Linlin
;
Guan, Yanhui
;
Chen, Shang
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/12
Luteolin-7-O-glucoside (LUTG)
starvation
autophagy
extracellular
signal regulated kinase (ERK)
mammalian target of rapamycin (mTOR)
IL-12 Influence mTOR to Modulate CD8(+) T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis
期刊论文
2017, 卷号: 14, 期号: 10, 页码: 977-983
作者:
Wang, Hao
;
Li, Jingdong
;
Han, Qiyang
;
Yang, Fei
;
Xiao, Yu
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/04
IL-12
Mammalian target of rapamycin (mTOR)
CD8(+) effect memory T cells (Tem)
Invasive Pulmonary Aspergillosis (IPA)
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