Anti-inflammatory  BMD, bone mineral density  BSA, bovine serum albumin  Bmp4, bone morphogenic protein 4  CRE, cyclic adenosine monophosphate response element  CREB, cyclic adenosine monophosphate response element binding protein  DEXA, dual-energy X-ray absorptiometry  DMSO, Dimethyl sulfoxide  Drynaria fortunei  E2, estradiol  ER, estrogen receptor  ERE, estrogen response element  Epimedium brevicornu  Estrogenic  FBS, fetal bovine serum  Fsk, forskolin  Hprt, hypoxanthine-guanine phosphoribosyl-transferase  IL-1, interleukin 1  LBD, ligand binding domain  LBM, low bone mass  M-CSF, macrophage colony-stimulating factor  MAPK, mitogen activated protein kinase  NF-κβ, nuclear factor kappa beta  OP, osteoporosis  Osteoporosis  PTH, parathyroid hormone  PTHrp, PTH related peptide  RANKL, receptor activator of nuclear factor kappa beta ligand  RLU, relative luminescence unit  ROI, region of interest  Runx2, runt-related transcription factor 2  SFM, serum free media  TCM, traditional Chinese medicine  TNFα, tumor necrosis factor alpha  TRAP, tartrate-resistant acid phosphatase  UAS, upstream activating sequence  cAMP, cyclic adenosine monophosphate  qPCR, quantitative polymerase chain reaction  

myasthenia gravis  interleukin-4 receptor  polymorphism  susceptibility  severity  

Akt  protein kinase B  Atg  autophagy related gene  CNS  central nervous system  COX-2  cyclooxygenase-2  CQ  chloroquine  ERK  extracellular signal-regulated kinase  IL-1β  interleukin-1β  iNOS  inducible nitric oxide synthase  JNK  c-jun NH2-terminal kinase  LPS  Lipopolysaccharide  MAPKs  mitogen-activated protein kinases  mTOR  mechanistic target of rapamycin  NO  nitric oxide  PI3K  phosphatidylinositol 3-kinase  PRR  pattern recognition receptor  TLR4  toll like receptor 4  TNF-α  tumor necrosis factor-α  20C  Autophagy  Mitogen-activated protein kinases (MAPKs)  Toll like receptor 4 (TLR4)  Protein kinase B (Akt)  Mechanistic target of rapamycin (mTOR)  

Akt  protein kinase B  Atg  autophagy related gene  CNS  central nervous system  COX-2  cyclooxygenase-2  CQ  chloroquine  ERK  extracellular signal-regulated kinase  IL-1β  interleukin-1β  iNOS  inducible nitric oxide synthase  JNK  c-jun NH2-terminal kinase  LPS  Lipopolysaccharide  MAPKs  mitogen-activated protein kinases  mTOR  mechanistic target of rapamycin  NO  nitric oxide  PI3K  phosphatidylinositol 3-kinase  PRR  pattern recognition receptor  TLR4  toll like receptor 4  TNF-α  tumor necrosis factor-α  20C  Autophagy  Mitogen-activated protein kinases (MAPKs)  Toll like receptor 4 (TLR4)  Protein kinase B (Akt)  Mechanistic target of rapamycin (mTOR)  

A1c  glycated hemoglobin  AACE  American Association of Clinical Endocrinologists  ACC  acetyl-CoA carboxylase  ADA  American Diabetes Association  Akt/PKB  tyrosine kinase/protein kinase B  AMP  adenosine monophosphate  AMPK  adenosine monophosphate-activated protein  Ang II  angiotensin II  ATP  adenosine triphosphate  BAT  brown adipose tissue  CHOP  CEBP-homologous protein  CEBP  CCAAT enhancer binding protein  CoA  coenzyme A  DPP  Diabetes Prevention Program  EASD  European Association for the Study of Diabetes  eNOS  endothelial nitric oxide synthase  ER  endoplasmic reticulum  FDA  Food and Drug Administration  FFA  free fatty acid  FOXO1  forkhead box protein O1  G6P  glucose 6-phosphate  GDM  gestational diabetes mellitus  GIPR  glucose-dependent insulinotropic polypeptide receptor  GLP-1R  glucagon-like peptide-1 receptor  GLUT1  glucose transporter-1  GLUT4  glucose transporter type 4  GLUTs  glucose transporters  G6P  glucose 6-phosphate, glucose transporter-1  GPR40  G protein-coupled receptor 40  HbA1c  hemoglobin A1c  HGP  hepatic glucose production  HSL  hormone sensitive lipase  IL-6  interleukin 6  INS-1  insulinoma cells in rat  IR  insulin resistance  IRS-1  insulin receptor substrate 1  JNK  c-Jun. N-terminal kinase  Kir6.2  inwardly rectifying potassium/kalium channel  LDs  lipid droplets  LDL  low density lipoprotein  LV  left ventricular  MIN6 cells  mouse insulinoma cells  MAPK  mitogen-activated protein kinases  mPTP  mitochondrial permeability transition pore opening  mTOR  mammalian target of rapamycin  NADPH  nicotinamide adenine dinucleotide phosphate  NF-kappaB  nuclear factors-kappa B  NIT-1 cells  insulinoma cells  p70S6K  p70 ribosomal S6 kinase  PA  palmitic acid  NOS  NADPH oxidase  p38 MAPK  p38 mitogen-activated protein kinase  PA  palmitic acid  PCOS  polycystic ovary syndrome  PGC-1α  peroxisome proliferator-activated receptor-g coactivator-1α  PI3K  phosphatidylinositol 3-kinase  PKB  protein kinase B  PKC  protein kinase C  PPARα  peroxisome-proliferator activated receptor α  PTP  permeability transition pore  RCT  randomized controlled trial  RISK  reperfusion injury salvage kinase  ROS  reactive oxygen species  SERCA2  reticulum sarcoplasmic Ca2 +-ATPase  RISK  reperfusion injury salvage kinase  Smad3  mothers against decapentaplegic homolog 3  SRC-2  steroid receptor coactivator 2  T1DM  Type 1 diabetes mellitus  T2DM  Type 2 diabetes mellitus  TGFβ1  transforming growth factor β1  TLR4  Toll-like receptor  TNF-α  tumor necrosis factor α  TR4  testicular receptor 4  UKPDS  United Kingdom Prospective Diabetes Study  VLDL  very low density lipoprotein  Metformin  Pancreatic β Cells  Heart failure  Insulin sensitizer