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碳氮稳定同位素比值在潮间带大型底栖动物组织间差异性研究 期刊论文
海洋学报, 2019, 卷号: 41, 期号: 4, 页码: 74-82
作者:  李宝泉
收藏  |  浏览/下载：38/0  |  提交时间：2020/06/17
潮间带  大型底栖动物  碳氮稳定同位素  食源和营养级分析  采样部位选取  intertidal zone  macrobenthos  carbon and nitrogen stable isotopes  food sources and trophic levels study,sampling parts  The technique of stable isotope analysis has been widely applied for the field of food web studies in recent years.However,few researches concerned about the impacts of different tissues used for analysis on the food web building.With the purpose of accuracy and comparability in the food web studies,the sampling tissues should be standardized.In this study,10macrobenthic species from the intertidal zone of the Yellow River Delta and Yantai were chosen as the target object to test the isotopic characteristic variations ofdelta~(13)C anddelta15 N at different body parts (whole bodies,muscles and gills).Our results show thatdelta~(13)C anddelta15 N values vary in different sampling tissues for most species,which indicates the different tissues used for analysis impact the food web building.To achieve a more accuracy and comparability result,suitable tissue should be primarily chosen for their food sources and trophic levels analysis.Namely,when the organism as predator,their muscles should first be chosen,for examples,adductor and foot muscles of mollusks,leg muscles of crabs and back muscles of fishes  when the organism as prey, most of their tissues,except for indigestible part(for polychaetes,the digestive tract contents should be removed) should be chosen for analysis on food sources and trophic levels of the secondary consumer,for example,whole soft parts of mollusks,the mixture of muscles and gills of crabs.  
基于语料库的中国英语专业学生英语文章中However一词的使用情况调查分析 期刊论文
2017, 卷号: 0, 期号: 12, 页码: 192
作者:  刘倩
收藏  |  浏览/下载：1/0  |  提交时间：2019/12/23
Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 5277-5285
作者:  Huang, Ruixue;  Ding, Ping;  Yang, Fei*
收藏  |  浏览/下载：15/0  |  提交时间：2019/12/03
CDH1  as a tumor suppressor gene  contributes sporadic breast cancer (BC) progression. However  the association between CDH1 hypermethylation and BC  and its clinicopathological significance remains unclear. We conducted a meta-analysis to investigate the relationship between the CDH1 methylation profile and the major clinicopathological features. A detailed literature was searched through the electronic databases PubMed  Web of Science™  and EMBASE™ for related research publications. The data were extracted and assessed by two reviewers independently. Odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated and summarized respectively. The frequency of CDH1 methylation was significantly higher in invasive ductal carcinoma than in normal breast tissues (OR =5.83  95% CI 3.76–9.03  P<0.00001). CDH1 hypermethylation was significantly higher in estrogen receptor (ER)-negative BC than in ER-positive BC (OR =0.62  95% CI 0.43–0.87  P=0.007). In addition  we found that the CDH1 was significantly methylated in HER2-negative BC than in HER2-positive BC (OR =0.26  95% CI 0.15–0.44  P<0.00001). However  CDH1 methylation frequency was not associated with progesterone receptor (PR) status  or with grades  stages  or lymph node metastasis of BC patients. Our results indicate that CDH1 hypermethylation is a potential novel drug target for developing personalized therapy. CDH1 hypermethylation is strongly associated with ER-negative and HER2-negative BC  respectively  suggesting CDH1 methylation status could contribute to the development of novel therapeutic approaches for the treatment of ER-negative or HER2-negative BC with aggressive tumor biology.  
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:  Zhang, Lei;  Xu, Xuan;  Yang, Ruhao;  Chen, Jingwen;  Wang, Shixuan
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However  the underlying molecular mechanism remains unclear. In this study  we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3  and inhibited the expression of fibronectin  alpha-smooth muscle actin (α-SMA)  and collagen I in cultured NRK-49F cells. S3I-201  an STAT3 inhibitor  also suppressed the expression of fibronectin  α-SMA  and collagen I in cultured NRK-49F cells. Mechanistically  paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore  paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin  α-SMA  and collagen I  and suppressed the infiltration of macrophages and production of TNF-α  IL-1β  TGF-β  and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation  consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis  and inhibition of proinflammatory cytokine production.  
一种稀土取代类Dawson结构硒钨酸盐的合成及性质研究 会议论文
2015年中西部地区无机化学化工学术研讨会, 2015-04-22
作者:  李海楼[1];  陈利娟[2];  赵俊伟[3]
收藏  |  浏览/下载：6/0  |  提交时间：2019/12/23
Molecular Weight Dependency of Crystallization and Melting Behavior of beta-Nucleated Isotactic Polypropylene 期刊论文
journal of polymer science part b-polymer physics, 2014, 卷号: 52, 期号: 19, 页码: 1301-1308
Lu, Ying; Wang, Qiao; Men, Yongfeng
收藏  |  浏览/下载：30/0  |  提交时间：2015/10/19
Compounds of isotactic polypropylene (iPP) and beta-nucleating agent were used to investigate the relationship between the development of beta phase and molecular weight in iPP under quiescent crystallization conditions by using wide angle X-ray diffraction and differential scanning calorimetry techniques. In all cases  the dependency of the formation of beta phase in iPP on molecular weight of iPP at a defined crystallization temperature range was found. The iPP with high molecular weight possessed a wide range of crystallization temperature in inducing rich beta phase. However  poor or even no beta phase was obtained for the samples with low molecular weight in the same range. In addition  an upper critical crystallization temperature of producing dominant beta phase was found at 125 degrees C. Beyond this temperature  a phenomenon of prevailing alpha phase became obvious. (C) 2014 Wiley Periodicals  Inc.  
An Approach for Identifying Cytokines Based on a Novel Ensemble Classifier 期刊论文
http://dx.doi.org/10.1155/2013/686090, 2013
Quan Zou; Zhen Wang; Xinjun Guan; Bin Liu; Yunfeng Wu; Ziyu Lin; 林子雨
收藏  |  浏览/下载：4/0  |  提交时间：2013/12/26
Increased expression of microRNA-335 predicts a favorable prognosis in primary gallbladder carcinoma 期刊论文
OncoTargets and Therapy, 2013, 卷号: 6, 页码: 1625-1630
作者:  Peng, Hong-hua;  Zhang, Yang-de;  Gong, Lian-sheng;  Liu, Wei-dong;  Zhang, Yang*
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
The application of adaptive enhancement algorithm based on gray entropy in mammary gland CR image (EI CONFERENCE) 会议论文
2012 2nd International Conference on Consumer Electronics, Communications and Networks, CECNet 2012, April 21, 2012 - April 23, 2012, Three Gorges, China
Zhang M.-H.; Zhang Y.-Y.
收藏  |  浏览/下载：26/0  |  提交时间：2013/03/25
Mammary gland is composed entirely of soft tissue with approximate density  therefore mammary gland CR medicine radiation image presents a low contrast  and slight difference changes may be a manifestation of tumor  so it is necessary to enhance mammary gland CR image to improve its visual quality in order to meet the demands of doctor's clinical diagnosis. However the general enhancement algorithms over enhance the contrast and noise  due to image details lost  aiming at the defects  a mammary gland CR medicine image adaptive enhancement arithmetic based on image gray entropy is put forward. The arithmetic adapts dizzy image to magnify selected spatial frequency response in order to enhance the edge details of mammary gland CR images. It can adjust weighted factor K according to image gray characteristics namely pixel gray entropy. Experiments results demonstrate that mammary gland CR image enhanced by the algorithm has abundant details and high signal-to-noise ratio  moreover  CR image enhanced has good visual effect. So the method is effective and fit for enhancing CR medical radiation image edge details. 2012 IEEE.  
Design of the real-time autofocusing system for collimator with long focus length and large aperture (EI CONFERENCE) 会议论文
2011 International Academic Conference on Numbers, Intelligence, Manufacturing Technology and Machinery Automation, MAMT 2011, December 24, 2011 - December 25, 2011, Wuhan, China
Li X.; Zhang X.
收藏  |  浏览/下载：35/0  |  提交时间：2013/03/25
Large aperture collimator which has been widely used for calibrating and testing various optical devices plays an essential role in correlative laboratories. As being the basic testing and calibration equipment  the large aperture collimator's accuracy should be much higher than the device under testing in order to ensure the accuracy of the measurement. However  the process of adjusting the collimator is extremely complicated due to the collimator's large aperture and long focal length. So it is difficult to ensure the measurement's quality and easy to cause the system being vulnerable to the surrounding environment. One of the most common problems is defocus. In order to solve the problem above  this issue presents a new type of autocollimator autofocusing system which uses pentaprism instead of using large-aperture plane mirror  semiconductor lasers as light source and CCD sensor as receiver. The system is smaller  lighter  and more convenient when using. The computer simulation shows that the autofocusing system's resolution could reach the accuracy of 40m. If we use the relevant algorithms to execute the sub-pixel scanning  the resolution could reach the accuracy of 10m. It shows that the system could satisfy the required testing precision of testing large aperture optical device.  

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