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Elevation of arachidonoylethanolamide levels by activation of the endocannabinoid system protects against colitis and ameliorates remote organ lesions in mice
期刊论文
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2017, 卷号: 14, 期号: 6
作者:
Zhao, Xiaolin
;
Liang, Peng
;
Liu, Jin
;
Jiang, Haixia
;
Fan, Xiaoshuai
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/04
URB597
fatty acid amide hydrolase
endocannabinoid system
colitis
blood-brain-barrier integrity
Docosahexaenoyl serotonin, an endogenously formed n-3 fatty acid-serotonin conjugate has anti-inflammatory properties by attenuating IL-23–IL-17 signaling in macrophages
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2016, 卷号: 1861, 期号: 12, 页码: 2020-2028
作者:
Poland, Mieke
;
ten Klooster, Jean Paul
;
Wang, Zheng
;
Pieters, Raymond
;
Boekschoten, Mark
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  |  
浏览/下载:9/0
  |  
提交时间:2019/12/23
AA-5-HT
arachidonoyl serotonin
AEA
arachidonoyl ethanolamide (anandamide)
COX-2
cyclooxygenase 2
DHA
docosahexaenoic acid (22:6n-3)
DHA-5-HT
docosahexaenoyl serotonin
DHEA
docosahexaenoyl ethanolamine
EPA-5-HT
eicosapentaenoyl serotonin
FAA
fatty acid amides
FAAH
fatty acid amide hydrolase
FDR
false discovery rate
GSEA
gene-set enrichment analysis
IL
Interleukin
n-3 LC PUFA
(n-3) long chain polyunsaturated fatty acid
LPS
lipopolysaccharide
NO
nitric oxide
NOS2
nitric oxide synthase 2
NES
normalized Enrichment Score
OA-5-HT
oleoyl serotonin
OEA
oleoyl ethanolamine
PA-5-HT
palmitoyl serotonin
TRPV1
transient receptor potential channel type V1
Acyl serotonines
DHA
DHA-5-HT
Nrf2
Intestine
Endocannabinoids
Structural and energetic insights into the selective interactions of monoacylglycerol lipase with its natural substrate and small-molecule inhibitors
期刊论文
MEDICINAL CHEMISTRY RESEARCH, 2014, 卷号: 23, 期号: 5, 页码: 2391-2404
作者:
Chen, Huayou
;
Sun, Tengyun
;
Chen, Hongzhang
;
Tian, Rui
;
Zhang, Tianxi
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浏览/下载:22/0
  |  
提交时间:2014/05/06
Monoacylglycerol lipase
Fatty acid amide hydrolase
Inhibitor selectivity
Quantum mechanics/molecular mechanics
Quantitative structure-selectivity relationship
抗肿瘤活性天然产物长链反侧-2-氨基-3-醇的不对称合成和cytosporone B的合成
学位论文
2011, 2011
陈碧双
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  |  
浏览/下载:3/0
  |  
提交时间:2016/02/14
丙氨酸
丝氨酸
长链反侧-2-氨基-3-醇
不对称合成
格氏加成
抗肿瘤活性
脂肪酸酰胺水解酶(FAAH)抑制剂
alanine
serine
long-chain anti-2-amino-3-alkanols
asymmetric synthesis
Grignard addition
antitumor activity
fatty acid amide hydrolase (FAAH)
cytosporone B
Quantitative structure-activity relationship study on the inhibitors of fatty acid amide hydrolase
期刊论文
JOURNAL OF CHEMOMETRICS, 2010, 卷号: 24, 期号: 9-10
-
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浏览/下载:3/0
  |  
提交时间:2014/12/05
QSAR
fatty acid amide hydrolase
molecular descriptor
heuristic method
support vector machine
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