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CORC

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Live or let die: Neuroprotective and anti-cancer effects of nutraceutical antioxidants 期刊论文
Pharmacology and Therapeutics, 2018, 卷号: 183, 页码: 137-151
作者:  Mao, Xiao-Yuan*;  Jin, Ming-Zhu;  Chen, Jin-Fei*;  Zhou, Hong-Hao;  Jin, Wei-Lin*
收藏  |  浏览/下载：13/0  |  提交时间：2019/12/03
PD  Parkinson's disease  AD  Alzheimer's disease  EGCG  (−)-Epigallocatechin-3-gallate  NRF2  NF-E2-related factor 2  ROS  reactive oxygen species  H2O2  hydrogen peroxide  ER  endoplasmic reticulum  GPX  glutathione-peroxidase  NOX  NADPH oxidases (NOXs)  LOX  lipoxygenases  ERK  extracellular signal-regulated kinase  JNK  c-Jun amino-terminal kinase  MAPK  mitogen-activated protein kinase  HNE  4-hydroxy-2-nonenol  ARE  antioxidant responsive element  GST  glutathione S-transferase  IFNγ  interferon-γ  LPS  lipopolysaccharide  SOD  superoxide dismutase  TNF-α  tumor necrosis factor-α  APP  β-amyloid precursor protein  SAM  S-adenosylmethionine  MAT  methionine adenosyltransferase  SAH  Sadenosyl homocysteine  MT  methyltransferases  BDNF  brain-derived neurotrophic factor  Nutraceuticals  Neuroprotection  Anti-cancer  ROS addiction  Ferroptosis  Oxidative stress  
Visualization of Alzheimer's Disease Related alpha-/beta-/gamma-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer 期刊论文
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 卷号: 11, 期号: 1, 页码: 431
作者:  Wang, Xin;  Pei, Gang
收藏  |  浏览/下载：29/0  |  提交时间：2019/04/28
Defining the minimum substrate and charge recognition model of gamma-secretase 期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 10, 页码: 1412-1424
作者:  Yan, Yan;  Xu, Ting-Hai;  Melcher, Karsten;  Xu, H. Eric
收藏  |  浏览/下载：16/0  |  提交时间：2019/01/08
The small molecule luteolin inhibits N-acetyl--galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 卷号: 292, 期号: 52
作者:  Liu, Feng;  Xu, Kai;  Xu, Zhijue;  de las Rivas, Matilde;  Wang, Congrong
收藏  |  浏览/下载：10/0  |  提交时间：2019/12/06
Fluorescent turn-on determination of the activity of peptidases using peptide templated gold nanoclusters 期刊论文
Microchimica Acta, 2016, 卷号: 183, 期号: 2, 页码: 605-610
作者:  Luo, Junjun;  Rasooly, Avraham;  Wang, Liqiang;  Zeng, Ke;  Shen, Congcong
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
BACE1 in the retina: a sensitive biomarker for monitoring early pathological changes in Alzheimer's disease 期刊论文
Neural Regeneration Research, 2016, 卷号: 11, 期号: 3, 页码: 447-453
作者:  Lan Li;  Jia Luo;  Dan Chen;  Jian-bin Tong;  Le-ping Zeng
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/03
Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein 期刊论文
NEUROSCIENCE BULLETIN, 2016
Yu, You; Li, Yinan; Zhang, Yan
收藏  |  浏览/下载：5/0  |  提交时间：2017/12/03
The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect 期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 162, 页码: 179-187
作者:  Chu, Shifeng;  Liu, Shaolin;  Duan, Wenzhen;  Cheng, Yong;  Jiang, Xueying
收藏  |  浏览/下载：9/0  |  提交时间：2019/12/27
Chirality  Clausenamide  Dementia  Long-term potentiation  Signaling pathway  Calcium  6-OHDA  6-hydroxyldopamine  ACE  acetylcholinesterase  ACh  acetylcholine  AD  Alzheimer's disease  AUC0–12 h  0–12 h area under curve  APP  amyloid precursor protein  APV  R-2-amino-5-phosphonopentanoate  AUC0−∝  whole area under curve  BBB  blood–brain barrier  BDNF  brain-derived neurotrophic factor  CaM  calmodulin  CaMKII  calmodulin kinase II  ChAT  choline acetyltransferase  CREB  cAMP responding element binding  CHM  Chinese herbal medicine  clau  clausenamide  CL  clearance  Cmax  maximum concentration  CDK-5  cyclin-dependent kinase-5  DM  diabetes mellitus  DAG  diacylglycerol  ER  endoplasmic reticulum  ERK  extracellular signal-regulated kinases  GSK-3  glycogen synthase kinase-3  IP3  inositol triphosphate  LTP  long term potentiation  MWM  Morris water maze  NGF  nerve growth factor  NMDA  N-Methyl-D-aspartate  D  nNOS  neural nitric oxide synthase  PAT  passive avoidance tasks  Pir  piracetam  PLC  phospholipase C  PP1  phosphate 1  PKC  protein kinase C  tmax  time of peak concentration  t1/2α  absorption half-life  t1/2β  elimination half-life  Tau  microtubule-associated proteins  TCM  traditional Chinese medicine  Vd  apparent volume of distribution  VDCC  voltage-dependent calcium channel  
Amyloid Precursor Protein Enhances Nav1.6 Sodium Channel Cell Surface Expression 期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 卷号: 290, 期号: 19
作者:  Liu, Chao;  Tan, Francis Chee Kuan;  Xiao, Zhi-Cheng;  Dawe, Gavin S.
收藏  |  浏览/下载：9/0  |  提交时间：2019/12/04
Association of IL-1, IL-18, and IL-33 gene polymorphisms with late-onset Alzheimer's disease in a Hunan Han Chinese population 期刊论文
Brain Research, 2015, 卷号: 1596, 期号: Volume 1596, 页码: 136-145
作者:  Tian, M;  Deng, Y Y;  Hou, D R;  Li, W;  Feng, X L
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
AD  Alzheimer׳s disease  LOAD  late-onset Alzheimer׳s disease  EOAD  early-onset Alzheimer׳s disease  Aβ  amyloid-beta  APOE  apolipoprotein E  APP  amy1iod precursor protein  CAA  cerebral amyloid angiopathy  CNS  central nervous system  IL  interleukin  ACT  alpha1-antichymotrypsin  TNF  tumor necrosis factor  BMI  body mass index  TC  total cholesterol  TG  triglycerides  HDL-c  high-density lipoprotein cholesterol  LDL-c  low-density lipoprotein cholesterol  OR  odds ratio  CI  confidence interval  MMSE  Mini-Mental State Examination  ADL  activities of daily living scale  CDT  clock drawing task  HAMD  hamilton depression scale  SNP  single nucleotide polymorphism  PCR  polymerase chain reaction  MALDI-TOF-MS  Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry  Alzheimer׳s disease  Inflammatory cytokines  IL-1 family  Single nucleotide polymorphism  

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