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中南大学 [5]
上海药物研究所 [3]
复旦大学上海医学院 [3]
清华大学 [2]
厦门大学 [2]
北京大学 [2]
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期刊论文 [26]
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2017 [2]
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Live or let die: Neuroprotective and anti-cancer effects of nutraceutical antioxidants
期刊论文
Pharmacology and Therapeutics, 2018, 卷号: 183, 页码: 137-151
作者:
Mao, Xiao-Yuan*
;
Jin, Ming-Zhu
;
Chen, Jin-Fei*
;
Zhou, Hong-Hao
;
Jin, Wei-Lin*
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2019/12/03
PD
Parkinson's disease
AD
Alzheimer's disease
EGCG
(−)-Epigallocatechin-3-gallate
NRF2
NF-E2-related factor 2
ROS
reactive oxygen species
H2O2
hydrogen peroxide
ER
endoplasmic reticulum
GPX
glutathione-peroxidase
NOX
NADPH oxidases (NOXs)
LOX
lipoxygenases
ERK
extracellular signal-regulated kinase
JNK
c-Jun amino-terminal kinase
MAPK
mitogen-activated protein kinase
HNE
4-hydroxy-2-nonenol
ARE
antioxidant responsive element
GST
glutathione S-transferase
IFNγ
interferon-γ
LPS
lipopolysaccharide
SOD
superoxide dismutase
TNF-α
tumor necrosis factor-α
APP
β-amyloid precursor protein
SAM
S-adenosylmethionine
MAT
methionine adenosyltransferase
SAH
Sadenosyl homocysteine
MT
methyltransferases
BDNF
brain-derived neurotrophic factor
Nutraceuticals
Neuroprotection
Anti-cancer
ROS addiction
Ferroptosis
Oxidative stress
Visualization of Alzheimer's Disease Related alpha-/beta-/gamma-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer
期刊论文
FRONTIERS IN MOLECULAR NEUROSCIENCE, 2018, 卷号: 11, 期号: 1, 页码: 431
作者:
Wang, Xin
;
Pei, Gang
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2019/04/28
Amyloid Precursor Protein
Beta-secretase
App
Site
Cleavage
Adam10
Bace1
Localization
Dimerization
Endocytosis
Defining the minimum substrate and charge recognition model of gamma-secretase
期刊论文
ACTA PHARMACOLOGICA SINICA, 2017, 卷号: 38, 期号: 10, 页码: 1412-1424
作者:
Yan, Yan
;
Xu, Ting-Hai
;
Melcher, Karsten
;
Xu, H. Eric
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2019/01/08
Alzheimer's disease
amyloid beta (A beta)
amyloid precursor protein (APP)
C99, gamma-secretase
minimum substrate
Notch protein
recognition model
The small molecule luteolin inhibits N-acetyl--galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2017, 卷号: 292, 期号: 52
作者:
Liu, Feng
;
Xu, Kai
;
Xu, Zhijue
;
de las Rivas, Matilde
;
Wang, Congrong
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2019/12/06
amyloid precursor protein (APP)
crystal structure
glycoprotein
glycosylation inhibitor
glycosyltransferase
O-glycosylation
luteolin
ppGalNAc-T
Fluorescent turn-on determination of the activity of peptidases using peptide templated gold nanoclusters
期刊论文
Microchimica Acta, 2016, 卷号: 183, 期号: 2, 页码: 605-610
作者:
Luo, Junjun
;
Rasooly, Avraham
;
Wang, Liqiang
;
Zeng, Ke
;
Shen, Congcong
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
beta-Secretases
APP cleaving enzyme
BACE1
beta-amyloid precursor protein
Transmission electron microscopy
Fluorometry
BACE1 in the retina: a sensitive biomarker for monitoring early pathological changes in Alzheimer's disease
期刊论文
Neural Regeneration Research, 2016, 卷号: 11, 期号: 3, 页码: 447-453
作者:
Lan Li
;
Jia Luo
;
Dan Chen
;
Jian-bin Tong
;
Le-ping Zeng
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/03
nerve
regeneration
neurodegenerative
disease
Alzheimer’s
disease
RETINA
amyloid-β
β-site
amyloid
precursor
protein
cleaving
enzyme
APP/PS-1
transgenic
mouse
neural
regeneration
nerve regeneration neurodegenerative disease Alzheimer's disease retina amyloid-β β-site amyloid precursor protein cleaving enzyme 1 APP/PS-1 transgenic mouse neural regeneration
Yeast Two-Hybrid Screening for Proteins that Interact with the Extracellular Domain of Amyloid Precursor Protein
期刊论文
NEUROSCIENCE BULLETIN, 2016
Yu, You
;
Li, Yinan
;
Zhang, Yan
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2017/12/03
Amyloid precursor protein
Alzheimer&apos
Yeast two-hybrid screening
Cell death
Pelizaeus-Merzbacher disease
PELIZAEUS-MERZBACHER DISEASE
APP-BINDING
SURFACE
FLRT3
CELL
OUTGROWTH
ADHESION
NEURONS
SYSTEM
FE65
s disease
The anti-dementia drug candidate, (-)-clausenamide, improves memory impairment through its multi-target effect
期刊论文
Pharmacology and Therapeutics, 2016, 卷号: 162, 页码: 179-187
作者:
Chu, Shifeng
;
Liu, Shaolin
;
Duan, Wenzhen
;
Cheng, Yong
;
Jiang, Xueying
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/27
Chirality
Clausenamide
Dementia
Long-term potentiation
Signaling pathway
Calcium
6-OHDA
6-hydroxyldopamine
ACE
acetylcholinesterase
ACh
acetylcholine
AD
Alzheimer's disease
AUC0–12 h
0–12 h area under curve
APP
amyloid precursor protein
APV
R-2-amino-5-phosphonopentanoate
AUC0−∝
whole area under curve
BBB
blood–brain barrier
BDNF
brain-derived neurotrophic factor
CaM
calmodulin
CaMKII
calmodulin kinase II
ChAT
choline acetyltransferase
CREB
cAMP responding element binding
CHM
Chinese herbal medicine
clau
clausenamide
CL
clearance
Cmax
maximum concentration
CDK-5
cyclin-dependent kinase-5
DM
diabetes mellitus
DAG
diacylglycerol
ER
endoplasmic reticulum
ERK
extracellular signal-regulated kinases
GSK-3
glycogen synthase kinase-3
IP3
inositol triphosphate
LTP
long term potentiation
MWM
Morris water maze
NGF
nerve growth factor
NMDA
N-Methyl-D-aspartate
D
nNOS
neural nitric oxide synthase
PAT
passive avoidance tasks
Pir
piracetam
PLC
phospholipase C
PP1
phosphate 1
PKC
protein kinase C
tmax
time of peak concentration
t1/2α
absorption half-life
t1/2β
elimination half-life
Tau
microtubule-associated proteins
TCM
traditional Chinese medicine
Vd
apparent volume of distribution
VDCC
voltage-dependent calcium channel
Amyloid Precursor Protein Enhances Nav1.6 Sodium Channel Cell Surface Expression
期刊论文
JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 卷号: 290, 期号: 19
作者:
Liu, Chao
;
Tan, Francis Chee Kuan
;
Xiao, Zhi-Cheng
;
Dawe, Gavin S.
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2019/12/04
Amyloid Precursor Protein (APP)
JNK
G Protein
Membrane Protein
Sodium Channel
Trafficking
Duolink
G(o) Protein
Nav1
6 Sodium Channels
Cell Surface Expression
Association of IL-1, IL-18, and IL-33 gene polymorphisms with late-onset Alzheimer's disease in a Hunan Han Chinese population
期刊论文
Brain Research, 2015, 卷号: 1596, 期号: Volume 1596, 页码: 136-145
作者:
Tian, M
;
Deng, Y Y
;
Hou, D R
;
Li, W
;
Feng, X L
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/03
AD
Alzheimer׳s disease
LOAD
late-onset Alzheimer׳s disease
EOAD
early-onset Alzheimer׳s disease
Aβ
amyloid-beta
APOE
apolipoprotein E
APP
amy1iod precursor protein
CAA
cerebral amyloid angiopathy
CNS
central nervous system
IL
interleukin
ACT
alpha1-antichymotrypsin
TNF
tumor necrosis factor
BMI
body mass index
TC
total cholesterol
TG
triglycerides
HDL-c
high-density lipoprotein cholesterol
LDL-c
low-density lipoprotein cholesterol
OR
odds ratio
CI
confidence interval
MMSE
Mini-Mental State Examination
ADL
activities of daily living scale
CDT
clock drawing task
HAMD
hamilton depression scale
SNP
single nucleotide polymorphism
PCR
polymerase chain reaction
MALDI-TOF-MS
Matrix Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry
Alzheimer׳s disease
Inflammatory cytokines
IL-1 family
Single nucleotide polymorphism
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