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科研机构
四川大学 [1]
内容类型
期刊论文 [1]
发表日期
2010 [1]
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Design, Synthesis and Biological Evaluation of Lipophilic Analogs of Anethol Trithione
期刊论文
Letters in Drug Design & Discovery, 2010, 卷号: Vol.7 No.10, 页码: 747-753
作者:
Xiao-Cen Li
;
Wei Fan
;
Li Hai
;
Shan Qian
;
Qui-Qi Xiao and Mei Guan
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提交时间:2019/03/26
Synthesis
Anethol
trithione
Lipophilicity
Bioavailability
Prodrugs
ATT
glutamyl
cysteine
synthetase
glutathione
GSH
IR
HNMR
ESI-MS
pyridine
hydrochloride
HPLC
alanine
transaminases
aspartate
transaminases
AST
Acute
Toxicity
Test
maximum
tolerated
dose
YRT-3
melting
point
apparatus
IR
spectra
Perkin-Elmer983
NMR
spectra
INOVA400
Bruker
AC-E200
Agilent
1946B
ESI-MS
instrument
5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
acetate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
propionate
(E)-4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
but-2-enoate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
isobutyrate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
benzoate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
2-phenylacetate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
stearate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
pivalate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
cinnamate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
2-fluorobenzoate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
4-chlorobenzoate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
3-phenylpropanoate
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
3,3-diphenylpropan-oate
(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
1,2,3,4-tetrahydro-naphthalene-1-carboxylate
(3o)
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl
5,6,7,8-tetrahydro-naphthalene-1-carboxylate
SPD-10A
variable
UV-VIS
detector
ODS
column
ICR
mice
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