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A strategy for comprehensive identification of sequential constituents using ultra-high-performance liquid chromatography coupled with linear ion trap-Orbitrap mass spectrometer, application study on chlorogenic acids in Flos Lonicerae Japonicae 期刊论文
Talanta, 2016, 卷号: 147, 页码: 16-27
作者:  Zhang, Jia-yu;  Wang, Zi-jian;  Li, Yun;  Liu, Ying;  Cai, Wei
收藏  |  浏览/下载:9/0  |  提交时间:2019/12/03
UPLC–LTQ–Orbitrap  ultra-high-performance liquid chromatography coupled with linear ion trap–Orbitrap  MIM  multiple ion monitoring  MTSF  mass spectral trees similarity filter  HRMS  high resolution mass spectrometer  CGAs  chlorogenic acids  FLJ  Flos Lonicerae Japonicae  DPIs  diagnostic product ions  TCMs  Traditional Chinese medicines  LC–MS  liquid chromatography tandem mass spectrometer  FS–PIL–DE  full scan–parent ions list–dynamic exclusion  ESI  electrospray ionization  PMFs  polymethoxylated flavonoids  CID  collision induced dissociation  SIM  selected ion monitoring  TECD  total extraction component detection  CQA  caffeoylquinic acid  DiCQA  dicaffeoylquinic acid  TriCQA  tricaffeoylquinic acid  pCoQA  p-coumaroylquinic acid  FQA  feruloylquinic acid  SQA  sinapoylquinic acid  pCoCQA  p-coumaroylcaffeoylquinic acid  CFQA  caffeoylferuloylquinic acid  pCoSQA  p-coumaroylsinapoylquinic acid  CSQA  caffeoylsinapoylquinic acid  FSQA  feruloylsinapoylquinic acid.  Chlorogenic acids  Ultra-high-performance liquid chromatography coupled with linear ion trap–Orbitrap  Flos Lonicerae Japonicae  Sequential constituents  
Tissue distribution of six major bio-active components after oral administration of Zhenqi Fuzheng capsules to rats using ultra-pressure liquid chromatography-tandem mass spectrometry 期刊论文
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2015, 卷号: 986, 页码: 44-53
作者:  Liu, XH;  Zhu, RJ;  Hu, F;  Guo, L;  Yang, YL
收藏  |  浏览/下载:6/0  |  提交时间:2016/09/02
Alternation of adriamycin penetration kinetics in MCF-7 cells from 2D to 3D culture based on P-gp expression through the Chk2/p53/NF-κB pathway 期刊论文
Biochemical Pharmacology, 2015, 卷号: 93, 期号: 2, 页码: 210-220
作者:  Lu, Meng;  Zhou, Fang;  Hao, Kun;  Liu, Jiali;  Chen, Qianying
收藏  |  浏览/下载:16/0  |  提交时间:2019/12/03
Adriamycin (PubChem CID: 31703)  LY335979 (PubChem CID: 153997)  AZD7762 (PubChem CID: 11152667)  Nutlin-3 (PubChem CID: 216345)  DMSO (PubChem CID: 679)  Propidium iodide (PubChem CID: 104981)  MTT formazan (PubChem CID: 16218671)  ADR  adriamycin  AUC  area under the concentration–time curve  ECM  extracellular matrix  ESI  electrospray ionization  HBSS  Hank's balanced salt solution  LC–MS/MS  liquid chromatography tandem mass spectrometry  MCL  multi-cellular layer  MCR  multi-cellular resistance  MCS  multi-cellular spheroid  MDR  multi-drug resistance  MRM  multiple reaction monitoring  P-gp  P-glycoprotein  PI  propidium iodide  qPCR  quantitative real-time PCR  S.E.  standard error  Multi-cellular layer  Penetration kinetics  P-gp  Chk2/p53/NF-κB pathway  
质子化胞嘧啶碰撞诱导解离的实验和理论研究 期刊论文
质谱学报, 2015, 卷号: 36, 页码: 385-393
作者:  陈华鹏[1];  张淑琴[2];  董俊国[3];  翁端[4];  程平[5]
收藏  |  浏览/下载:4/0  |  提交时间:2019/04/30
Characterization of laminaran and a highly sulfated polysaccharide from Sargassum fusiforme 期刊论文
CARBOHYDRATE RESEARCH, 2014, 卷号: 385, 页码: 58-64
作者:  Jin, Weihua;  Zhang, Wenjing;  Wang, Jing;  Ren, Sumei;  Song, Ni
收藏  |  浏览/下载:24/0  |  提交时间:2015/06/11
Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller 期刊论文
Journal of Ethnopharmacology, 2014, 卷号: 152, 期号: 3, 页码: 470-477
作者:  Xie, Lian-Wu;  Atanasov, Atanas G.;  Guo, De-An;  Malainer, Clemens;  Zhang, Jing-Xian
收藏  |  浏览/下载:8/0  |  提交时间:2019/12/28
1D NMR  one-dimensional nuclear magnetic resonance spectroscopy  2D NMR  two-dimensional nuclear magnetic resonance spectroscopy  ANOVA  analysis of variance  AP-1  activator protein 1  CC  column chromatography  CDCl3  deuterated chloroform  C/EBP  CCAAT/enhancer binding protein  CHCl3  chloroform  COSY  correlation spectroscopy in 2D NMR  DCM  dichloromethane  EGFP  enhanced green fluorescent protein  ESI-MS  electrospray ionization mass spectrometry  DMEM  Dulbecco׳s modified Eagle׳s medium  DMSO  dimethyl sulfoxide  EtOAc  ethyl acetate  EtOH  ethanol  FBS  fetal bovine serum  HEK293  human embryonic kidney 293  HMBC  heteronuclear multiple-bond correlation spectroscopy in 2D NMR  HPLC  high performance liquid chromatography  HSQC  heteronuclear single-quantum correlation spectroscopy in 2D NMR  IC50  half maximal inhibitory concentration  IκB  inhibitor of kappa B  IL-6  interleukin 6  IL-1β  interleukin-1 beta  MeOH  methanol  NF-κB  nuclear factor κB  NMR  nuclear magnetic resonance spectroscopy  PE  petroleum ether  PPARγ  peroxisome proliferator-activated receptor γ  TCM  traditional Chinese medicine  TLC  thin layer chromatography  TNF-α  tumor necrosis factor α  Trans-N-(p-coumaroyl)tyramine (PubChem CID: 5372945)  Trans-N-feruloyltyramine (PubChem CID: 5280537)  Trans-N-caffeoyltyramine (PubChem CID: 9994897)  Dihydro-N-caffeoyltyramine (PubChem CID: 16119668)  CHEMBL2337120 (PubChem CID: 71524307)  CHEMBL2337119 (PubChem CID: 71524308)  CHEMBL2337118 (PubChem CID: 71524309)  CHEMBL2337115 (PubChem CID: 71719510)  CHEMBL2337117 (PubChem CID: 71524310)  Lycium chinense Miller  Lycii Radicis Cortex  NF-κB  PPARγ  Phenolic amides  Fatty acids  
Activity-guided isolation of NF-κB inhibitors and PPARγ agonists from the root bark of Lycium chinense Miller 期刊论文
Journal of Ethnopharmacology, 2014, 卷号: 152, 期号: 3, 页码: 470-477
作者:  Xie, Lian-Wu;  Atanasov, Atanas G.;  Guo, De-An;  Malainer, Clemens;  Zhang, Jing-Xian
收藏  |  浏览/下载:4/0  |  提交时间:2019/12/27
1D NMR  one-dimensional nuclear magnetic resonance spectroscopy  2D NMR  two-dimensional nuclear magnetic resonance spectroscopy  ANOVA  analysis of variance  AP-1  activator protein 1  CC  column chromatography  CDCl3  deuterated chloroform  C/EBP  CCAAT/enhancer binding protein  CHCl3  chloroform  COSY  correlation spectroscopy in 2D NMR  DCM  dichloromethane  EGFP  enhanced green fluorescent protein  ESI-MS  electrospray ionization mass spectrometry  DMEM  Dulbecco׳s modified Eagle׳s medium  DMSO  dimethyl sulfoxide  EtOAc  ethyl acetate  EtOH  ethanol  FBS  fetal bovine serum  HEK293  human embryonic kidney 293  HMBC  heteronuclear multiple-bond correlation spectroscopy in 2D NMR  HPLC  high performance liquid chromatography  HSQC  heteronuclear single-quantum correlation spectroscopy in 2D NMR  IC50  half maximal inhibitory concentration  IκB  inhibitor of kappa B  IL-6  interleukin 6  IL-1β  interleukin-1 beta  MeOH  methanol  NF-κB  nuclear factor κB  NMR  nuclear magnetic resonance spectroscopy  PE  petroleum ether  PPARγ  peroxisome proliferator-activated receptor γ  TCM  traditional Chinese medicine  TLC  thin layer chromatography  TNF-α  tumor necrosis factor α  Trans-N-(p-coumaroyl)tyramine (PubChem CID: 5372945)  Trans-N-feruloyltyramine (PubChem CID: 5280537)  Trans-N-caffeoyltyramine (PubChem CID: 9994897)  Dihydro-N-caffeoyltyramine (PubChem CID: 16119668)  CHEMBL2337120 (PubChem CID: 71524307)  CHEMBL2337119 (PubChem CID: 71524308)  CHEMBL2337118 (PubChem CID: 71524309)  CHEMBL2337115 (PubChem CID: 71719510)  CHEMBL2337117 (PubChem CID: 71524310)  Lycium chinense Miller  Lycii Radicis Cortex  NF-κB  PPARγ  Phenolic amides  Fatty acids  
Structural analysis of sulfated fucan from Saccharina japonica by electrospray ionization tandem mass spectrometry 期刊论文
CARBOHYDRATE RESEARCH, 2013, 卷号: 369, 页码: 63-67
作者:  Jin, Weihua;  Guo, Zhimou;  Wang, Jing;  Zhang, Wenjing;  Zhang, Quanbin
收藏  |  浏览/下载:24/0  |  提交时间:2014/07/17
Structural analysis of sulfated fucan from Saccharina japonica by electrospray ionization tandem mass spectrometry 期刊论文
carbohydrate research, 2013, 卷号: 369, 页码: 63-67
作者:  Jin, Weihua;  Guo, Zhimou;  Wang, Jing;  Zhang, Wenjing;  Zhang, Quanbin
收藏  |  浏览/下载:16/0  |  提交时间:2015/11/09
Structural analysis of sulfated fucan from Saccharina japonica by electrospray ionization tandem mass spectrometry 期刊论文
carbohydrate research, 2013, 卷号: 369, 页码: 63-67
作者:  Jin, Weihua;  Guo, Zhimou;  Wang, Jing;  Zhang, Wenjing;  Zhang, Quanbin
收藏  |  浏览/下载:16/0  |  提交时间:2015/11/09


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