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上海药物研究所 [4]
中南大学 [4]
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期刊论文 [49]
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Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell
期刊论文
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 卷号: 23, 期号: 2
作者:
Si, Yibing
;
Liu, Junfeng
;
Shen, Hongliang
;
Zhang, Chen
;
Wu, Yuanhao
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2019/12/05
5-hydroxymethylation
cell cyclin-dependent kinases
fisetin
renal cancer stem cells
Fisetin decreases TET1 activity and CCNY/CDK16 promoter 5hmC levels to inhibit the proliferation and invasion of renal cancer stem cell
期刊论文
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 2019, 卷号: 23, 期号: 2
作者:
Si, Yibing
;
Liu, Junfeng
;
Shen, Hongliang
;
Zhang, Chen
;
Wu, Yuanhao
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/12/05
5-hydroxymethylation
cell cyclin-dependent kinases
fisetin
renal cancer stem cells
Regulatory role of calpain in neuronal death
期刊论文
Neural Regeneration Research, 2018, 卷号: 13, 期号: 3, 页码: 556-562
作者:
Cheng, Si-ying
;
Wang, Shu-chao
;
Lei, Ming
;
Wang, Zhen
;
Xiong, Kun*
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/03
nerve regeneration
calpain
calpastatin
central nervous system
apoptosis
autophagy
B-cell lymphoma
cyclin-dependent kinases
mitochondrial permeability transition
neural regeneration
Progress of CDK4/6 Inhibitor Palbociclib in the Treatment of Cancer
期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2018, 卷号: 18, 期号: 9, 页码: 1241-1251
作者:
Chen, Fengquan
;
Liu, Chunxi
;
Zhang, Jian
;
Xu, Wenfang
;
Zhang, Yingjie
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2019/12/11
Cyclin-Dependent Kinases (CDKs)
palbociclib
monotherapy
combined
therapy
anti-cancer
cell cycle arrest
Epigenetic Dysregulation of the Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increases Mitotic Mitochondrial Fission and Promotes Pulmonary Arterial Hypertension: Mechanistic and Therapeutic Implications
期刊论文
2018, 卷号: 138, 期号: 3, 页码: 287-304
作者:
Chen, Kuang-Hueih
;
Dasgupta, Asish
;
Lin, Jianhui
;
Potus, Francois
;
Bonnet, Sebastien
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/03
cell cycle
cyclin-dependent kinases
dynamin-related protein 1
microRNAs
mitochondrial dynamics
mitochondrial fission
pulmonary arterial hypertension
A2-type cyclin is required for the asymmetric entry division in rice stomatal development
期刊论文
JOURNAL OF EXPERIMENTAL BOTANY, 2018, 卷号: 69, 期号: 15, 页码: 3587-3599
作者:
Qu, Xiaoxiao
;
Yan, Min
;
Zou, Junjie
;
Jiang, Min
;
Yang, Kezhen
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2022/02/25
Cyclin-dependent kinases
cell differentiation
cell division
guard mother cells
cyclin
rice
stomata
Kinases Involved in Both Autophagy and Mitosis
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 卷号: 18, 期号: 9, 页码: 1-15
作者:
Li, Zhiyuan
;
Zhang, Xin
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2018/08/17
Kinases
Autophagy
Mitosis
Cyclin-dependent Kinases
Aurora
Polo-like Kinases
Development of Selective Cyclin-Dependent Kinase 4 Inhibitors for Antineoplastic Therapies
期刊论文
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2017, 卷号: 17, 期号: 5
作者:
Guan, Haixing
;
Du, Yongli
;
Han, Weiwei
;
Shen, Jingkang
;
Li, Qunyi
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2019/12/05
Anti-cancer agents
cell cycle
clinical trials
cyclin-dependent kinases 4
selective inhibitors
structure activity relationship (SAR)
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
Computational study of non-catalytic T-loop pocket on CDK proteins for drug development
期刊论文
Chinese Physics B, 2017, 卷号: 26, 期号: 12, 页码: 128702-1-128702-9
作者:
Wang, Huiwen
;
Wang, Kaili
;
Guan, Zeyu
;
Jian, Yiren
;
Jia, Ya
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2019/12/23
cyclin-dependent kinases
non-catalytic
TL pocket
inhibitor design
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