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浏览/检索结果: 共5条，第1-5条 帮助 已选(0)清除 条数/页：5101520253035404550556065707580859095100   排序方式：请选择作者升序作者降序题名升序题名降序发表日期升序发表日期降序提交时间升序提交时间降序 Apoptosis induction and G2/M arrest of 2-methyl-1,3,6-trihydroxy-9,10-anthraquinone from Rubia yunnanensis in human cervical cancer HeLa cells 期刊论文 PHARMAZIE, 2013, 卷号: 68, 期号: 4, 页码: 293-299 作者:  Zeng, Guang-Zhi;  Fan, Jun-Ting;  Xu, Jun-Ju;  Li, Yan;  Tan, Ning-Hua 收藏  |  浏览/下载：28/0  |  提交时间：2015/05/14 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone (MTA)  one of the major components isolated from the traditional  Chinese medicine Rubia yunnanensis  exhibited inhibitory activity on the proliferation of several  human cancer cell lines. The results from an annexin V-FITC (fluoresein-5-isothiocyanate) apoptosis assay  and DNA content analysis showed that MTA exerted cytotoxicity via apoptosis induction and G2/M cell cycle  arrest in human cervical carcinoma HeLa cells. Further  MTA was found to induce apoptosis of HeLa cells  through the mitochondria-mediated pathway. It caused the translocation of Bax to the mitochondria and  release of cytochrome c into the cytosol  which caused the cleavage of caspase and poly(ADP-ribose)  polymerase and finally triggered the apoptosis. Furthermore  the p53/p21/Cdc2-cyclin B1 signaling was  found related to the G2/M arrest caused by MTA. The over-expression of p21 and down-expression of  cyclin B1 caused by MTA inactivated the Cdc2-cyclin B1 complex of G2/M checkpoint and finally caused  the G2/M arrest in HeLa cells. This study demonstrated that MTA is a potential anti-cancer component of  R. yunnanensis  a folk anti-cancer herb used in Yunnan  China.   Galanin Protects Amyloid-beta-Induced Neurotoxicity on Primary Cultured Hippocampal Neurons of Rats 期刊论文 journal of alzheimers disease, 2010 Cheng, Yong; Yu, Long-Chuan 收藏  |  浏览/下载：2/0  |  提交时间：2015/11/14 Amyloid-beta  Bax  Bcl-2  caspase-3  Gal2-11  galanin  galanin receptor 2  hippocampal neuron  MAP2  Morris water maze  neuroprotective effect  p53  ALZHEIMERS-DISEASE  A-BETA  TAUROURSODEOXYCHOLIC ACID  P53-MEDIATED APOPTOSIS  PRECURSOR PROTEIN  BAX TRANSLOCATION  NUCLEUS BASALIS  NERVOUS-SYSTEM  CELL-DEATH  PEPTIDE   The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells 期刊论文 欧洲生化学会联合会快报, 2010 Liu, Xiang; Feng, Renqing; Du, Liying 收藏  |  浏览/下载：3/0  |  提交时间：2015/11/11 Breast cancer  Apoptosis  4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine  Enoyl-CoA hydratase short chain 1  Peroxiredoxin 3  TYROSINE KINASE INHIBITOR  BCL-2 FAMILY-MEMBERS  LUNG-CANCER  ANTIESTROGEN RESISTANCE  BAX TRANSLOCATION  DEATH PATHWAYS  CYTOCHROME-C  SRC  ACTIVATION  OVEREXPRESSION   ga3anewgambogicacidderivativeexhibitspotentantitumoractivitiesinvitroviaapoptosisinvolvedmechanisms 期刊论文 actapharmacologicasinica, 2009, 卷号: 30, 期号: 3, 页码: 346 作者:  Hua XIE;  Yuxin QIN;  Yunlong ZHOU;  Linjiang TONG;  Liping LIN 收藏  |  浏览/下载：3/0  |  提交时间：2020/07/01 DRUG DISCOVERY  CELLS  BAX  PROTEIN  TRANSLOCATION  CYTOTOXICITY  PATHWAY  BINDING  DOMAIN  DEATH  gambogic acid  GA3  antitumor  apoptosis  caspase  Bcl-2  cytochrome c