The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in   PP2-induced apoptosis in human breast cancer MCF-7 cells

doi:10.1016/j.febslet.2010.06.002

CORC > 北京大学 > 生命科学学院

	The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells
	Liu, Xiang ; Feng, Renqing ; Du, Liying
刊名	欧洲生化学会联合会快报
	2010
关键词	Breast cancer Apoptosis 4-Amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine Enoyl-CoA hydratase short chain 1 Peroxiredoxin 3 TYROSINE KINASE INHIBITOR BCL-2 FAMILY-MEMBERS LUNG-CANCER ANTIESTROGEN RESISTANCE BAX TRANSLOCATION DEATH PATHWAYS CYTOCHROME-C SRC ACTIVATION OVEREXPRESSION
DOI	10.1016/j.febslet.2010.06.002
英文摘要	We show that 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine (PP2) induces apoptosis and down-regulates the expression of enoyl-CoA hydratase short chain 1 (ECHS1) and peroxiredoxin 3 (PRDX3) in human breast cancer MCF-7 cells. The decrease of ECHS1 and PRDX3 was validated by Western blot and quantitative real-time reverse transcription-PCR in MCF-7 and other carcinoma cells. Knockdown and over-expression of ECHS1 and/or PRDX3 further supported the key role of ECHS1 and PRDX3 in regulation of PP2-induced apoptosis. These results suggest a possible apoptotic pathway whereby down-regulation of ECHS1 and PRDX3 potentiates PP2-induced apoptosis in MCF-7 cells. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000279438800037&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Biophysics; Cell Biology; SCI(E); PubMed; 26; ARTICLE; 14; 3185-3192; 584
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/195294]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, Xiang,Feng, Renqing,Du, Liying. The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells[J]. 欧洲生化学会联合会快报,2010.
APA	Liu, Xiang,Feng, Renqing,&Du, Liying.(2010).The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells.欧洲生化学会联合会快报.
MLA	Liu, Xiang,et al."The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells".欧洲生化学会联合会快报 (2010).