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CORC

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Recyclable Surface-Enhanced Raman Scattering Substrate-Based Sensors for Various Applications 期刊论文
ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 2023, 卷号: 11, 期号: 4, 页码: 1278-1293
作者:  Zhang, Zhiyang;  Yang, Shixuan;  Zhao, Rongfang;  Chen, Jiadong;  Wang, Shasha
收藏  |  浏览/下载：12/0  |  提交时间：2023/08/17
Intense high-frequency laser-field control of spin-orbit coupling in GaInAs/AlInAs quantum wells: A laser dressing effect 期刊论文
PHYSICAL REVIEW B, 2022, 卷号: 106
作者:  Li, Xue;  Wang, Wei;  Zhao, Ning;  Yang, Hao;  Han, Shixuan
收藏  |  浏览/下载：19/0  |  提交时间：2022/12/23
A deep-learning-based framework for severity assessment of COVID-19 with CT images 期刊论文
EXPERT SYSTEMS WITH APPLICATIONS, 2021, 卷号: 185, 页码: 11
作者:  Li, Zhidan;  Zhao, Shixuan;  Chen, Yang;  Luo, Fuya;  Kang, Zhiqing
收藏  |  浏览/下载：48/0  |  提交时间：2021/12/01
SCOAT-Net: A novel network for segmenting COVID-19 lung opacification from CT images 期刊论文
PATTERN RECOGNITION, 2021, 卷号: 119, 页码: 12
作者:  Zhao, Shixuan;  Li, Zhidan;  Chen, Yang;  Zhao, Wei;  Xie, Xingzhi
收藏  |  浏览/下载：18/0  |  提交时间：2021/12/01
Non-powered capillary force-driven stamped approach for directly printing nanomaterials aqueous solution on paper substrate 期刊论文
LAB ON A CHIP, 2020, 卷号: 20, 期号: 5, 页码: 931-941
作者:  Yi, Langlang;  Zhao, Lei;  Xue, Qilu;  Cheng, He;  Shi, Hongyan
收藏  |  浏览/下载：17/0  |  提交时间：2020/06/02
Slowing down DNA translocation by a nanofiber meshed layer 期刊论文
JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2018, 卷号: 51, 期号: 4, 页码: 6
作者:  Zhao, Yue;  Xie, Wanyi;  Tian, Enling;  Ren, Yiwei;  Zhu, Jifeng
收藏  |  浏览/下载：47/0  |  提交时间：2018/03/05
Thrombopoietin knock-in augments platelet generation from human embryonic stem cells 期刊论文
2018, 卷号: 9, 期号: 1, 页码: 194
作者:  Zhang, Leisheng;  Liu, Cuicui;  Wang, Hongtao;  Wu, Dan;  Su, Pei
收藏  |  浏览/下载：14/0  |  提交时间：2020/01/03
Prognostic risk model development and prospective validation among patients with cervical cancer stage IB2 to IIB submitted to neoadjuvant chemotherapy 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6
作者:  Huang, Kecheng;  Sun, Haiying;  Li, Xiong;  Hu, Ting;  Yang, Ru
收藏  |  浏览/下载：9/0  |  提交时间：2019/12/05
Optimal pathological response indicated better long-term outcome among patients with stage IB2 to IIB cervical cancer submitted to neoadjuvant chemotherapy 期刊论文
SCIENTIFIC REPORTS, 2016, 卷号: 6
作者:  Huang, Kecheng;  Sun, Haiying;  Chen, Zhilan;  Li, Xiong;  Wang, ShaoShuai
收藏  |  浏览/下载：7/0  |  提交时间：2019/12/05
Paclitaxel attenuates renal interstitial fibroblast activation and interstitial fibrosis by inhibiting STAT3 signaling 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 2139-2148
作者:  Zhang, Lei;  Xu, Xuan;  Yang, Ruhao;  Chen, Jingwen;  Wang, Shixuan
收藏  |  浏览/下载：4/0  |  提交时间：2019/12/03
Recent studies have demonstrated that paclitaxel might inhibit renal fibrosis. However  the underlying molecular mechanism remains unclear. In this study  we hypothesized that low-dose paclitaxel may block the STAT3 (signal transducer and activator of transcription 3) signaling to attenuate fibrosis in a mouse model with unilateral ureteral obstruction. Both NRK-49F cells and mice with unilateral ureteral obstruction were treated with paclitaxel. The results showed that paclitaxel treatment resulted in a dose- and time-dependent decrease in tyrosine-phosphorylated STAT3  and inhibited the expression of fibronectin  alpha-smooth muscle actin (α-SMA)  and collagen I in cultured NRK-49F cells. S3I-201  an STAT3 inhibitor  also suppressed the expression of fibronectin  α-SMA  and collagen I in cultured NRK-49F cells. Mechanistically  paclitaxel treatment blocked the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation. Furthermore  paclitaxel also ameliorated renal fibrosis by down-regulating the expression of fibronectin  α-SMA  and collagen I  and suppressed the infiltration of macrophages and production of TNF-α  IL-1β  TGF-β  and ICAM-1 (intercellular adhesion molecule 1) by inhibition of STAT3 activity in obstructive nephropathy. These results suggest that paclitaxel may block the STAT3 activity by disrupting the association of STAT3 with tubulin and inhibiting STAT3 nucleus translocation  consequently leading to the suppression of renal interstitial fibroblast activation and the development of renal fibrosis  and inhibition of proinflammatory cytokine production.  

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