Slowing down DNA translocation by a nanofiber meshed layer

doi:10.1088/1361-6463/aa9ec8

CORC > 重庆绿色智能技术研究院 > 中国科学院重庆绿色智能技术研究院 > 精准医疗单分子诊断技术研究中心

	Slowing down DNA translocation by a nanofiber meshed layer
	Zhao, Yue; Xie, Wanyi; Tian, Enling; Ren, Yiwei; Zhu, Jifeng; Deng, Yunsheng; He, Shixuan; Liang, Liyuan; Wang, Yunjiao; Zhou, Daming
刊名	JOURNAL OF PHYSICS D-APPLIED PHYSICS
	2018-01-31
卷号	51 期号:4 页码:6
关键词	solid-state nanopore nanofiber DNA sequencing Poisson-Nernst-Planck equation
ISSN号	0022-3727
DOI	10.1088/1361-6463/aa9ec8
英文摘要	Due to the weak interaction between DNA molecules and the inner surface of nanopores, DNA translocation is very fast, just leaving a short current drop without sufficient information to recognise the nucleotide sequence in the strand. In this paper, we propose a nanopore-nanofiber mesh hybridized structure to decelerate DNA translocation speed. Experimental results reveal that due to hydrophobic interaction between the DNA fragments and the nanofibers, the DNA moving speed can be retarded to two orders of magnitude slower. Furthermore, according to theory simulations, the additional fiber layer will reduce the electric field in the channel but elongate the capture region at the pore orifice, which will be helpful for increasing the capture rate and extending the DNA dwelling time in the meanwhile.
资助项目	Instrument Development Program of Chinese Academy of Sciences[YZ201568] ; National Natural Science Foundations of China NNSFC[61701474] ; West Light Foundation of CAS ; Chongqing Sci. & Technol. Commission ; NNSFC[61471336] ; NNSFC[21507131] ; NNSFC[51503206] ; NNSFC[61504146]
WOS研究方向	Physics
语种	英语
出版者	IOP PUBLISHING LTD
WOS记录号	WOS:000419615200001
内容类型	期刊论文
源URL	[http://172.16.51.4:88/handle/2HOD01W0/81]
专题	精准医疗单分子诊断技术研究中心中国科学院重庆绿色智能技术研究院
通讯作者	Zhao, Yue
作者单位	Chongqing Inst Green & Intelligent Technol, Chongqing Key Lab Multiscale Mfg Technol, Chongqing 400714, Peoples R China
推荐引用方式 GB/T 7714	Zhao, Yue,Xie, Wanyi,Tian, Enling,et al. Slowing down DNA translocation by a nanofiber meshed layer[J]. JOURNAL OF PHYSICS D-APPLIED PHYSICS,2018,51(4):6.
APA	Zhao, Yue.,Xie, Wanyi.,Tian, Enling.,Ren, Yiwei.,Zhu, Jifeng.,...&Wang, Deqiang.(2018).Slowing down DNA translocation by a nanofiber meshed layer.JOURNAL OF PHYSICS D-APPLIED PHYSICS,51(4),6.
MLA	Zhao, Yue,et al."Slowing down DNA translocation by a nanofiber meshed layer".JOURNAL OF PHYSICS D-APPLIED PHYSICS 51.4(2018):6.