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科研机构
上海药物研究所 [68]
上海大学 [2]
复旦大学上海医学院 [2]
内容类型
期刊论文 [72]
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2021 [4]
2019 [5]
2018 [5]
2017 [3]
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2015 [3]
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Design, Synthesis, and Biological Evaluation of Novel Pyrimido[4,5-b]indole Derivatives Against Gram-Negative Multidrug-Resistant Pathogens
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2021, 卷号: 64, 期号: 12, 页码: 8644-8665
作者:
Kong, Qidi
;
Pan, Wei
;
Xu, Heng
;
Xue, Yaru
;
Guo, Bin
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2021/08/17
Improved Practical Synthesis of DY-038, an Oral Available Antiplatelet Agent
期刊论文
CHEMISTRYSELECT, 2021, 卷号: 6, 期号: 13, 页码: 3183-3186
作者:
Cao, Yangzhi
;
Kong, Deyu
;
Sun, Lulu
;
Meng, Xin
;
Zhang, Yinyong
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2021/08/17
antiplatelet agent
cyclization
DY-038
process development
sulfonamides
Recent advances in antibacterial agents
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 卷号: 35, 页码: 8
作者:
Kong, Qidi
;
Yang, Yushe
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2021/05/24
Antimicrobial resistance
Antibacterial agents
Gram-negative bacteria
Gram-positive bacteria
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2021, 卷号: 31, 页码: 13
作者:
Wang, Ao
;
Wang, Yawan
;
Meng, Xin
;
Yang, Yushe
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2021/05/24
Androgen receptor
Novel thiohydantoin derivatives
Androgen receptor antagonists
Prostate cancer
Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria
期刊论文
JOURNAL OF CHEMICAL RESEARCH, 2019, 卷号: 43, 期号: 9-10, 页码: 380-385
作者:
Chen, Peng
;
Zhang, Yinyong
;
Shi, Chenghui
;
Meng, Xin
;
Yang, Yushe
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2020/07/01
chiral separation
Gram-positive bacteria
oxazolidinone
practical synthesis
YG-056SP
Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 6, 页码: 2950-2973
作者:
Shi, Chenghui
;
Zhang, Yinyong
;
Wang, Ting
;
Lu, Wenchao
;
Zhang, Shuhua
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Optimization of P2Y(12) Antagonist Ethyl 6-(4-((Benzylsulfonyl)carbarnoyl)piperidin-1-yl)-5-cyano-2-methylnicotinate (AZD1283) Led to the Discovery of an Oral Antiplatelet Agent with Improved Druglike Properties
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 6, 页码: 3088-3106
作者:
Kong, Deyu
;
Xue, Tao
;
Guo, Bin
;
Cheng, Jianjun
;
Liu, Shunyin
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2020/07/01
Synthesis and biological evaluation of novel potent FFA1 agonists containing 2,3-dihydrobenzo[b][1,4]dioxine
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 卷号: 29, 期号: 6, 页码: 848-852
作者:
Kong, Deyu
;
Guo, Shimeng
;
Yang, Yushe
;
Guo, Bin
;
Xie, Xin
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2020/07/01
FFA1 agonist
2,3-Dihydrobenzo[b][1,4]dioxine
Insulin secretion
Type 2 diabetes mellitus
Synthesis and Biological Evaluation of Oxopyrido[2,3-d] Pyrimidine-7-ones Derivatives as Covalent L85812/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors
期刊论文
LETTERS IN DRUG DESIGN & DISCOVERY, 2019, 卷号: 16, 期号: 8, 页码: 826-834
作者:
Niu, Ao
;
Wang, Yang
;
Yang, Yushe
;
Wei, Jianhai
;
Ding, Jian
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2020/07/01
Non-small cell lung cancer
irreversible inhibitors
EGFR(T79014)( )mutant
anti-tumor
xenograft model
cell proliferation
Design and optimization of 2,3-dihydrobenzo[b][1,4]dioxine propanoic acids as novel GPR40 agonists with improved pharmacokinetic and safety profiles
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 22, 页码: 5780-5791
作者:
Guo, Bin
;
Guo, Shimeng
;
Huang, Jing
;
Li, Jingya
;
Li, Jia
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2019/01/08
GPR40 agonist
2,3-Dihydrobenzo[b][1,4]dioxine
Insulin secretion
Type 2 diabetes mellitus
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