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Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria
Chen, Peng1; Zhang, Yinyong2; Shi, Chenghui2; Meng, Xin2; Yang, Yushe2; Zhou, Xianli1; Guo, Bin2
刊名JOURNAL OF CHEMICAL RESEARCH
2019-09-01
卷号43期号:9-10页码:380-385
关键词chiral separation Gram-positive bacteria oxazolidinone practical synthesis YG-056SP
ISSN号1747-5198
DOI10.1177/1747519819868198
通讯作者Guo, Bin(guobin@simm.ac.cn)
英文摘要An improved process for the synthesis of YG-056SP, a potent oxazolidinone candidate against multi-drug resistant bacteria, is developed. Compared with the original synthetic route, this new approach is two steps shorter, and all of the steps involve simple purifications without column chromatography. More importantly, it avoids the use of explosive azide compounds and expensive metal catalysts. The new reaction conditions are mild and safe, which is more suitable for the scalable synthesis of YG-056SP for preclinical studies.
资助项目Youth Innovation Promotion Association of the Chinese Academy of Sciences[2016262]
WOS关键词ANTIBIOTICS ; INFECTIONS
WOS研究方向Chemistry
语种英语
出版者SAGE PUBLICATIONS LTD
WOS记录号WOS:000490982700010
内容类型期刊论文
源URL[http://119.78.100.183/handle/2S10ELR8/282580]  
专题中国科学院上海药物研究所
通讯作者Guo, Bin
作者单位1.Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu, Sichuan, Peoples R China
2.Univ Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714
Chen, Peng,Zhang, Yinyong,Shi, Chenghui,et al. Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria[J]. JOURNAL OF CHEMICAL RESEARCH,2019,43(9-10):380-385.
APA Chen, Peng.,Zhang, Yinyong.,Shi, Chenghui.,Meng, Xin.,Yang, Yushe.,...&Guo, Bin.(2019).Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria.JOURNAL OF CHEMICAL RESEARCH,43(9-10),380-385.
MLA Chen, Peng,et al."Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria".JOURNAL OF CHEMICAL RESEARCH 43.9-10(2019):380-385.
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