Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria

doi:10.1177/1747519819868198

	Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria
	Chen, Peng 1; Zhang, Yinyong 2; Shi, Chenghui 2; Meng, Xin 2; Yang, Yushe 2; Zhou, Xianli 1; Guo, Bin 2
刊名	JOURNAL OF CHEMICAL RESEARCH
	2019-09-01
卷号	43 期号:9-10 页码:380-385
关键词	chiral separation Gram-positive bacteria oxazolidinone practical synthesis YG-056SP
ISSN号	1747-5198
DOI	10.1177/1747519819868198
通讯作者	Guo, Bin(guobin@simm.ac.cn)
英文摘要	An improved process for the synthesis of YG-056SP, a potent oxazolidinone candidate against multi-drug resistant bacteria, is developed. Compared with the original synthetic route, this new approach is two steps shorter, and all of the steps involve simple purifications without column chromatography. More importantly, it avoids the use of explosive azide compounds and expensive metal catalysts. The new reaction conditions are mild and safe, which is more suitable for the scalable synthesis of YG-056SP for preclinical studies.
资助项目	Youth Innovation Promotion Association of the Chinese Academy of Sciences[2016262]
WOS关键词	ANTIBIOTICS ; INFECTIONS
WOS研究方向	Chemistry
语种	英语
出版者	SAGE PUBLICATIONS LTD
WOS记录号	WOS:000490982700010
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/282580]
专题	中国科学院上海药物研究所
通讯作者	Guo, Bin
作者单位	1.Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu, Sichuan, Peoples R China 2.Univ Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China
推荐引用方式 GB/T 7714	Chen, Peng,Zhang, Yinyong,Shi, Chenghui,et al. Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria[J]. JOURNAL OF CHEMICAL RESEARCH,2019,43(9-10):380-385.
APA	Chen, Peng.,Zhang, Yinyong.,Shi, Chenghui.,Meng, Xin.,Yang, Yushe.,...&Guo, Bin.(2019).Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria.JOURNAL OF CHEMICAL RESEARCH,43(9-10),380-385.
MLA	Chen, Peng,et al."Improved synthesis of YG-056SP, a potent oxazolidinone antibacterial candidate against multi-drug resistant bacteria".JOURNAL OF CHEMICAL RESEARCH 43.9-10(2019):380-385.