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科研机构
上海药物研究所 [13]
上海中医药大学 [2]
内容类型
期刊论文 [15]
发表日期
2021 [1]
2020 [1]
2019 [3]
2018 [1]
2017 [1]
2014 [3]
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Synthesis and pharmacological evaluation of choroquine derivatives bearing long aminated side chains as antivirus and anti-inflammatory agents
期刊论文
BIOORGANIC CHEMISTRY, 2021, 卷号: 116, 页码: 8
作者:
Song, Zilan
;
Liu, Yuting
;
Xie, Chenghu
;
Tong, Xiankun
;
Wang, Xue
收藏
  |  
浏览/下载:77/0
  |  
提交时间:2021/11/04
Choroquine
Aminochloroquine
Antivirus
Anti-inflammatory
Cytokines
Discovery of Phthalazinone Derivatives as Novel Hepatitis B Virus Capsid Inhibitors
期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 63, 期号: 15, 页码: 8134-8145
作者:
Chen, Wuhong
;
Liu, Feifei
;
Zhao, Qiliang
;
Ma, Xinna
;
Lu, Dong
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2020/12/24
CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 515, 期号: 3, 页码: 403-409
作者:
Liu, Jianan
;
Yang, Li
;
Liu, Feifei
;
Li, Heng
;
Tang, Wei
收藏
  |  
浏览/下载:65/0
  |  
提交时间:2020/07/01
CNOT2
Dengue virus
IFN
JAK-STAT pathway
ISGs
Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives
期刊论文
ACS INFECTIOUS DISEASES, 2019, 卷号: 5, 期号: 5, 页码: 713-724
作者:
Yang, Li
;
Liu, Feifei
;
Tong, Xiankun
;
Hoffmann, Daniel
;
Zuo, Jianping
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
hepatitis B virus
HBV core protein
HBcAg
capsid assembly
capsid assembly modulators (CAMs)
antiviral therapy
clinical trials
CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway
期刊论文
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 卷号: 515, 期号: 3
作者:
Liu, Jianan
;
Yang, Li
;
Liu, Feifei
;
Li, Heng
;
Tang, Wei
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2019/12/05
CNOT2
Dengue virus
IFN
JAK-STAT pathway
ISGs
Discovery and optimization of phthalazinone derivatives as a new class of potent dengue virus inhibitors
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 卷号: 145, 页码: 328-337
作者:
Lu, Dong
;
Liu, Jianan
;
Zhang, Yunzhe
;
Liu, Feifei
;
Zeng, Limin
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Phthalazinone
Dengue virus
Inhibitor
Optimization
SAR
Optimization and Synthesis of Pyridazinone Derivatives as Novel Inhibitors of Hepatitis B Virus by Inducing Genome-free Capsid Formation
期刊论文
ACS INFECTIOUS DISEASES, 2017, 卷号: 3, 期号: 3, 页码: 199-205
作者:
Lu, Dong
;
Liu, Feifei
;
Xing, Weiqiang
;
Tong, Xiankun
;
Wang, Lang
收藏
  |  
浏览/下载:36/0
  |  
提交时间:2019/01/08
pyridazinone
HBV DNA-free capsids
drug-like optimization
SAR study
lead candidate
discoveringnovelantihcvcompoundswithinhibitoryactivitiestowardhcvns34aprotease
期刊论文
actapharmacologicasinica, 2014, 卷号: 35, 期号: 8, 页码: 1074
作者:
Yu Ye
;
Jing Jingfeng
;
Tong Xiankun
;
He Peilan
;
Li Yuanchao
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2020/07/01
HEPATITIS-C VIRUS
PLUS RIBAVIRIN
REPLICATION
TELAPREVIR
POTENT
EPIDEMIOLOGY
BOCEPREVIR
hepatitis C virus
NS3/4A protease
secreted embryonic alkaline phosphatase (Seap)
2,4-diaminoquinazoline
carboxamide
telaprevir
lsothlafliudilne, a novel non-nucleoside compound, inhibits hepatitis B virus replication through blocking pregenomic RNA encapsidation
期刊论文
Acta Pharmacologica Sinica, 2014, 卷号: 35, 期号: 3, 页码: 410
作者:
Yang Li
;
Shi Liping
;
Chen Haijun
;
Tong Xiankun
;
Wang Guifeng
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2020/12/24
hepatitis B
virus replication
capsid assembly
pregenomic RNA
non-nucleoside compound
isothiafludine
lamivudine
adefovir
entecavir
lsothlafliudilneanovelnonnucleosidecompoundinhibitshepatitisbvirusreplicationthroughblockingpregenomicrnaencapsidation
期刊论文
actapharmacologicasinica, 2014, 卷号: 35, 期号: 3, 页码: 410
作者:
Yang Li
;
Shi Liping
;
Chen Haijun
;
Tong Xiankun
;
Wang Guifeng
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2020/07/01
hepatitis B
virus replication
capsid assembly
pregenomic RNA
non-nucleoside compound
isothiafludine
lamivudine
adefovir
entecavir
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