Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives

doi:10.1021/acsinfecdis.8b00337

	Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives
	Yang, Li 2; Liu, Feifei 2,3; Tong, Xiankun 2; Hoffmann, Daniel 1; Zuo, Jianping 2; Lu, Mengji 4
刊名	ACS INFECTIOUS DISEASES
	2019-05-01
卷号	5 期号:5 页码:713-724
关键词	hepatitis B virus HBV core protein HBcAg capsid assembly capsid assembly modulators (CAMs) antiviral therapy clinical trials
ISSN号	2373-8227
DOI	10.1021/acsinfecdis.8b00337
通讯作者	Lu, Mengji(mengji.li@uni-due.de)
英文摘要	On the basis of the recent advance of basic research on molecular biology of hepatitis B virus (HBV) infection, novel antiviral drugs targeting various steps of the HBV life cycle have been developed in recent years. HBV nucleocapsid assembly is now recognized as a hot target for anti-HBV drug development. Structural and functional analysis of HBV nucleocapsid allowed rational design and improvement of small molecules with the ability to interact with the components of HBV nucleocapsid and modulate the viral nucleocapsid assembly process. Prototypes of small molecule modulators targeting HBV nucleocapsid assembly are being preclinically tested or have moved forward in clinical trials, with promising results. This Review summarizes the recent advances in the approach to develop antiviral drugs based on the modulation of HBV nucleocapsid assembly. The antiviral mechanisms of small molecule modulators beyond the capsid formation and the potential implications will be discussed.
资助项目	National Science Foundation of Shanghai[DFG TRR60] ; [17ZR1436400]
WOS关键词	CORE PROTEIN ; PEGYLATED INTERFERON ; CRYSTAL-STRUCTURE ; NVR 3-778 ; REPLICATION ; DERIVATIVES ; INHIBITORS ; PARTICLES ; GENOME ; COMBINATION
WOS研究方向	Pharmacology & Pharmacy ; Infectious Diseases
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000468015100007
内容类型	期刊论文
源URL	[http://119.78.100.183/handle/2S10ELR8/289793]
专题	中国科学院上海药物研究所
通讯作者	Lu, Mengji
作者单位	1.Univ Duisburg Essen, Inst Bioinformat, Univ Str 1, D-45117 Essen, Germany 2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Lab Immunopharmacol, Zhangjiang Hitech Pk,555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Univ Duisburg Essen, Univ Hosp Essen, Inst Virol, Hufelandstr 55, D-45122 Essen, Germany
推荐引用方式 GB/T 7714	Yang, Li,Liu, Feifei,Tong, Xiankun,et al. Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives[J]. ACS INFECTIOUS DISEASES,2019,5(5):713-724.
APA	Yang, Li,Liu, Feifei,Tong, Xiankun,Hoffmann, Daniel,Zuo, Jianping,&Lu, Mengji.(2019).Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives.ACS INFECTIOUS DISEASES,5(5),713-724.
MLA	Yang, Li,et al."Treatment of Chronic Hepatitis B Virus Infection Using Small Molecule Modulators of Nucleocapsid Assembly: Recent Advances and Perspectives".ACS INFECTIOUS DISEASES 5.5(2019):713-724.