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Association analysis of interleukin-18 gene promoter region polymorphisms and susceptibility to sporadic breast cancer in Chinese Han women 期刊论文
2018, 卷号: 32, 期号: 9, 页码: e22591
作者:  Qiao, Xuefeng;  Xu, Danfei;  Sun, Dandan;  Sun, Sijin;  Huang, Zhiping
收藏  |  浏览/下载：9/0  |  提交时间：2020/01/03
FOXC1 overexpression is a marker of poor response to anthracycline-based adjuvant chemotherapy in sporadic triple-negative breast cancer 期刊论文
2017, 卷号: 79, 期号: 6, 页码: 1205-1213
作者:  Xu Y L;  Yao R;  Li J;  Zhou Y D;  Mao F
收藏  |  浏览/下载：2/0  |  提交时间：2020/01/04
Association between genetic variants of EGF-containing fibulin-like extracellular matrix protein1 gene and sporadic breast cancer in a Chinese Han population 期刊论文
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY, 2016, 卷号: 37, 期号: 1
作者:  Li, X.;  Quan, Y.;  Tang, C.;  Chen, Y.
收藏  |  浏览/下载：3/0  |  提交时间：2019/12/13
DNA Repair Genes XRCC1 and ERCC1 Polymorphisms and the Risk of Sporadic Breast Cancer in Han Women in the Gansu Province of China 期刊论文
GENETIC TESTING AND MOLECULAR BIOMARKERS, 2015, 卷号: 19, 期号: 7, 页码: 387-393
作者:  Zhu, GJ;  Wang, L;  Guo, HY;  Lu, LG;  Yang, SS
收藏  |  浏览/下载：4/0  |  提交时间：2017/01/13
Clinicopathological significance and potential drug target of CDH1 in breast cancer: a meta-analysis and literature review 期刊论文
Drug Design, Development and Therapy, 2015, 卷号: 9, 页码: 5277-5285
作者:  Huang, Ruixue;  Ding, Ping;  Yang, Fei*
收藏  |  浏览/下载：15/0  |  提交时间：2019/12/03
CDH1  as a tumor suppressor gene  contributes sporadic breast cancer (BC) progression. However  the association between CDH1 hypermethylation and BC  and its clinicopathological significance remains unclear. We conducted a meta-analysis to investigate the relationship between the CDH1 methylation profile and the major clinicopathological features. A detailed literature was searched through the electronic databases PubMed  Web of Science™  and EMBASE™ for related research publications. The data were extracted and assessed by two reviewers independently. Odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated and summarized respectively. The frequency of CDH1 methylation was significantly higher in invasive ductal carcinoma than in normal breast tissues (OR =5.83  95% CI 3.76–9.03  P<0.00001). CDH1 hypermethylation was significantly higher in estrogen receptor (ER)-negative BC than in ER-positive BC (OR =0.62  95% CI 0.43–0.87  P=0.007). In addition  we found that the CDH1 was significantly methylated in HER2-negative BC than in HER2-positive BC (OR =0.26  95% CI 0.15–0.44  P<0.00001). However  CDH1 methylation frequency was not associated with progesterone receptor (PR) status  or with grades  stages  or lymph node metastasis of BC patients. Our results indicate that CDH1 hypermethylation is a potential novel drug target for developing personalized therapy. CDH1 hypermethylation is strongly associated with ER-negative and HER2-negative BC  respectively  suggesting CDH1 methylation status could contribute to the development of novel therapeutic approaches for the treatment of ER-negative or HER2-negative BC with aggressive tumor biology.  
The possible role of EZH2 and DNMT1 polymorphisms in sporadic triple-negative breast carcinoma in southern Chinese females 期刊论文
TUMOR BIOLOGY, 2015, 卷号: 36, 期号: 12
作者:  Tao, Ran;  Chen, Zekun;  Wu, Pingping;  Liu, Cuicui;  Peng, You
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/06
Hypermethylation of BRCA1 gene: implication for prognostic biomarker and therapeutic target in sporadic primary triple-negative breast cancer 期刊论文
2015, 卷号: 150, 期号: 3, 页码: 479-486
作者:  Zhu, X.;  Shan, L.;  Wang, F.;  Wang, J.;  Shen, G.
收藏  |  浏览/下载：2/0  |  提交时间：2020/01/13
Gender-specific association of NFKBIA promoter polymorphisms with the risk of sporadic colorectal cancer 期刊论文
Medical oncology, 2013, 期号: 4, 页码: 1-6
作者:  Zheng,L.;  Liang,W.;  Guo,Q.;  Liu,Y.;  Roncati,L.
收藏  |  浏览/下载：2/0  |  提交时间：2019/12/23
Epstein-Barr Virus Infection and Sporadic Breast Cancer Risk: A Meta-Analysis 期刊论文
PLOS ONE, 2012, 卷号: 7, 期号: 2
作者:  Huo, Qiang;  Zhang, Ning;  Yang, Qifeng
收藏  |  浏览/下载：11/0  |  提交时间：2019/12/23
BRCA基因的克隆，表达与纯化 学位论文
2011, 2011
李振
收藏  |  浏览/下载：3/0  |  提交时间：2016/02/14

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