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科研机构
上海药物研究所 [2]
兰州大学 [1]
昆明植物研究所 [1]
中南大学 [1]
复旦大学上海医学院 [1]
湖南大学 [1]
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期刊论文 [9]
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2020 [1]
2019 [4]
2018 [1]
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2015 [1]
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chemistry [1]
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Preliminary study on radiosensitivity to carbon ions in human breast cancer
期刊论文
JOURNAL OF RADIATION RESEARCH, 2020, 卷号: 61, 期号: 3, 页码: 399-409
作者:
Zhang, Qiuning
;
Kong, Yarong
;
Yang, Zhen
;
Liu, Yang
;
Liu, Ruifeng
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/01/12
carbon ions
breast cancer
MDA-MB-231
MCF-7
Akt/mTOR/p70S6K pathway
radiosensitivity
Blocking ROR1 enhances the roles of erlotinib in lung adenocarcinoma cell lines
期刊论文
ONCOLOGY LETTERS, 2019, 卷号: 18, 期号: 3, 页码: 2977-2984
作者:
Wang, Hui-Li
;
Liu, Yan-Chun
;
Long, Ming-Peng
;
Zheng, Chuan
;
Yang, Jia-Hui
收藏
  |  
浏览/下载:98/0
  |  
提交时间:2019/11/07
receptor tyrosine kinase-like orphan receptor 1
lung adenocarcinoma
erlotinib resistance
AKT
mammalian target of rapamycin
small interfering RNA
Astragaloside IV ameliorates high glucose-induced renal tubular epithelial-mesenchymal transition by blocking mTORC1/p70S6K signaling in HK-2 cells
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2019, 卷号: 43, 期号: 2
作者:
Chen, Xiao
;
Yang, Yang
;
Liu, Chenxu
;
Chen, Zhigao
;
Wang, Dongdong
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2019/12/05
astragaloside IV
renal tubular
epithelial-mesenchymal transition
mammalian target of rapamycin complex 1
ribosomal protein S6 kinase-1 signaling
Astragaloside IV ameliorates high glucose-induced renal tubular epithelial-mesenchymal transition by blocking mTORC1/p70S6K signaling in HK-2 cells
期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2019, 卷号: Vol.43 No.2, 页码: 709-716
作者:
Chen, Xiao
;
Yang, Yang
;
Liu, Chenxu
;
Chen, Zhigao
;
Wang, Dongdong
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2019/12/17
astragaloside IV
renal tubular
epithelial-mesenchymal transition
mammalian target of rapamycin complex 1
ribosomal protein S6 kinase-1 signaling
aberrantmodulationofribosomalproteins6phosphorylationconfersacquiredresistancetomapkpathwayinhibitorsinbrafmutantmelanoma
期刊论文
中国药理学报英文版, 2019, 卷号: 040, 期号: 002, 页码: 268
作者:
Mingzhao Gao
;
Hongbin Wang
;
Xiangling Chen
;
Wenting Cao
;
Li Fu
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2020/07/01
BRAF-mutant
melanoma
MAPK
pathway
inhibitors
acquired
resistance
P70S6K
RSK
rpS6
G1/G0
phase
arrest
mTOR
inhibitor
Aberrant modulation of ribosomal protein S6 phosphorylation confers acquired resistance to MAPK pathway inhibitors in BRAF-mutant melanoma
期刊论文
Acta pharmacologica Sinica, 2018
作者:
Gao, Ming-Zhao
;
Wang, Hong-Bin
;
Chen, Xiang-Ling
;
Cao, Wen-Ting
;
Fu, Li
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2019/01/08
Metformin, beyond an insulin sensitizer, targeting heart and pancreatic β cells
期刊论文
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2017, 卷号: 1863, 期号: 8, 页码: 1984-1990
作者:
Yang, Xin
;
Xu, Zhipeng
;
Zhang, Chunlan
;
Cai, Zixin
;
Zhang, Jingjing*
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2019/12/03
A1c
glycated hemoglobin
AACE
American Association of Clinical Endocrinologists
ACC
acetyl-CoA carboxylase
ADA
American Diabetes Association
Akt/PKB
tyrosine kinase/protein kinase B
AMP
adenosine monophosphate
AMPK
adenosine monophosphate-activated protein
Ang II
angiotensin II
ATP
adenosine triphosphate
BAT
brown adipose tissue
CHOP
CEBP-homologous protein
CEBP
CCAAT enhancer binding protein
CoA
coenzyme A
DPP
Diabetes Prevention Program
EASD
European Association for the Study of Diabetes
eNOS
endothelial nitric oxide synthase
ER
endoplasmic reticulum
FDA
Food and Drug Administration
FFA
free fatty acid
FOXO1
forkhead box protein O1
G6P
glucose 6-phosphate
GDM
gestational diabetes mellitus
GIPR
glucose-dependent insulinotropic polypeptide receptor
GLP-1R
glucagon-like peptide-1 receptor
GLUT1
glucose transporter-1
GLUT4
glucose transporter type 4
GLUTs
glucose transporters
G6P
glucose 6-phosphate, glucose transporter-1
GPR40
G protein-coupled receptor 40
HbA1c
hemoglobin A1c
HGP
hepatic glucose production
HSL
hormone sensitive lipase
IL-6
interleukin 6
INS-1
insulinoma cells in rat
IR
insulin resistance
IRS-1
insulin receptor substrate 1
JNK
c-Jun. N-terminal kinase
Kir6.2
inwardly rectifying potassium/kalium channel
LDs
lipid droplets
LDL
low density lipoprotein
LV
left ventricular
MIN6 cells
mouse insulinoma cells
MAPK
mitogen-activated protein kinases
mPTP
mitochondrial permeability transition pore opening
mTOR
mammalian target of rapamycin
NADPH
nicotinamide adenine dinucleotide phosphate
NF-kappaB
nuclear factors-kappa B
NIT-1 cells
insulinoma cells
p70S6K
p70 ribosomal S6 kinase
PA
palmitic acid
NOS
NADPH oxidase
p38 MAPK
p38 mitogen-activated protein kinase
PA
palmitic acid
PCOS
polycystic ovary syndrome
PGC-1α
peroxisome proliferator-activated receptor-g coactivator-1α
PI3K
phosphatidylinositol 3-kinase
PKB
protein kinase B
PKC
protein kinase C
PPARα
peroxisome-proliferator activated receptor α
PTP
permeability transition pore
RCT
randomized controlled trial
RISK
reperfusion injury salvage kinase
ROS
reactive oxygen species
SERCA2
reticulum sarcoplasmic Ca2 +-ATPase
RISK
reperfusion injury salvage kinase
Smad3
mothers against decapentaplegic homolog 3
SRC-2
steroid receptor coactivator 2
T1DM
Type 1 diabetes mellitus
T2DM
Type 2 diabetes mellitus
TGFβ1
transforming growth factor β1
TLR4
Toll-like receptor
TNF-α
tumor necrosis factor α
TR4
testicular receptor 4
UKPDS
United Kingdom Prospective Diabetes Study
VLDL
very low density lipoprotein
Metformin
Pancreatic β Cells
Heart failure
Insulin sensitizer
The synergistic inhibition of breast cancer proliferation by combined treatment with 4EGI-1 and MK2206
期刊论文
2015, 卷号: 14, 期号: 2, 页码: 232-242
作者:
Wang, Hongtao
;
Huang, Fang
;
Wang, Jian
;
Wang, Peng
;
Lv, Wenjie
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2020/01/13
AKT
eIF4E
eIF4F complex
cap-dependent translation
4EBP1
4EGI-1
mTORC1
mTORC2
eIF4E
eukaryotic translation initiation factor 4E
4EBP1
eIF4E-binding protein 1
p70S6K
ribosomal p70 S6 kinase
mTORC1
mammalian target of rapamycin complex 1
mTORC2 mammalian target of rapamycin complex 2
PI3K
phosphatidylinositol 3-kinase
ER stress
endoplasmic reticulum stress
Trans-3,4,5,4 '-tetramethoxystilbene, a resveratrol analog, potently inhibits angiogenesis in vitro and in vivo
期刊论文
ACTA PHARMACOLOGICA SINICA, 2013, 卷号: 34, 期号: 9
作者:
Chen, LK
;
Qiang, PF
;
Xu, QP
;
Zhao, YH
;
Dai, F
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2014/12/05
angiogenesis
trans-3,4,5,4 '-tetramethoxystilbene
resveratrol
endothelial cell
VEGF
VEGF receptor 2
c-Src
Erk1/2
Akt
mTOR
focal adhesion kinase (FAK)
ribosomal protein S6 kinase (p70S6K)
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