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上海药物研究所 [12]
西北高原生物研究所 [9]
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期刊论文 [37]
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Efficacy and safety of anlotinib with and without EGFR-TKIs or immunotherapy in the treatment of elder patients with non-small-cell lung cancer: a retrospective study
期刊论文
BMC PULMONARY MEDICINE, 2022, 卷号: 22
作者:
Wang, Wenxian
;
Shao, Lan
;
Xu, Yibing
;
Song, Zhengbo
;
Lou, Guangyuan
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2022/12/23
Non-small cell lung cancer
Prognosis
Angiogenesis
Tyrosine kinase inhibitors
Recent advances in dopaminergic strategies for the treatment of Parkinson's disease
期刊论文
ACTA PHARMACOLOGICA SINICA, 2020, 页码: 12
作者:
Mao, Qi
;
Qin, Wang-zhi
;
Zhang, Ao
;
Ye, Na
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2020/07/01
Parkinson's disease
dopamine
D-1 receptor
D-2 receptor
allosteric modulator
neuroprotection
multitarget
drug discovery and development
neurodegenerative diseases
Design, synthesis and evaluation of vilazodone-tacrine hybrids as multitarget-directed ligands against depression with cognitive impairment
期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 卷号: 26, 期号: 12, 页码: 3117-3125
作者:
Liu, Wenwen
;
Wang, Huan
;
Li, Xiaokang
;
Xu, Yixiang
;
Zhang, Jian
收藏
  |  
浏览/下载:40/0
  |  
提交时间:2019/01/08
Depression
Cognitive impairment
Multitarget-directed ligand
5-HT1A agonist
5-HT reuptake inhibition
ChE inhibition
Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetyicholinesterase (AChE) and Phosphodiesterase 5 (PDE5)
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 7, 页码: 1625-1636
作者:
Ni, Wei
;
Wang, Huan
;
Li, Xiaokang
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:44/0
  |  
提交时间:2019/01/08
Multifunctional agents
AChE inhibitors
PDE5 inhibitors
Alzheimer's disease
Discovery of Novel Topoisomerase II Inhibitors by Medicinal Chemistry Approaches.
期刊论文
Journal of Medicinal Chemistry, 2018, 期号: ~, 页码: ~
作者:
Wei Hu
;
Yue-Mao Shen
;
Zhi-Yu Li
;
Xun Li
;
Yong-Tang Zheng
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2018/09/20
Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2018, 卷号: 9, 期号: 2, 页码: 328-345
作者:
Mao, Fei
;
Wang, Huan
;
Ni, Wei
;
Zheng, Xinyu
;
Wang, Manjiong
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2019/01/08
Alzheimer's disease
drug repositioning
dual-target inhibitor
AChE inhibition
PDE5 inhibition
Design, Synthesis and in Combo Antidiabetic Bioevaluation of Multitarget Phenylpropanoic Acids
期刊论文
MOLECULES, 2018, 卷号: 23, 期号: 2
作者:
Colin-Lozano, Blanca
;
Estrada-Soto, Samuel
;
Chavez-Silva, Fabiola
;
Gutierrez-Hernandez, Abraham
;
Ceron-Romero, Litzia
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2019/01/08
diabetes
GPR40
AKRB1
PPAR gamma
GLUT-4
Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation
期刊论文
BIOORGANIC CHEMISTRY, 2018, 卷号: 81
作者:
He, Qi
;
Liu, Jing
;
Lan, Jin-Shuai
;
Ding, Jiaoli
;
Sun, Yongbing
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2019/12/05
Coumarin
Dithiocarbamate
Cholinesterase
Monoamine oxidase
Alzheimer's disease
Novel Vilazodone Tacrine Hybrids as Potential Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease Accompanied with Depression: Design, Synthesis, and Biological Evaluation
期刊论文
ACS CHEMICAL NEUROSCIENCE, 2017, 卷号: 8, 期号: 12, 页码: 2708-2721
作者:
Li, Xiaokang
;
Wang, Huan
;
Xu, Yixiang
;
Liu, Wenwen
;
Gong, Qi
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2019/01/08
Alzheimer's disease
depression
multitarget-directed ligand
ChE inhibition
5-HT1A agonist
5-HT reuptake inhibition
Discovery of novel anti-angiogenesis agents. Part 7: Multitarget inhibitors of VEGFR-2, TIE-2 and EphB4
期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 卷号: 141, 页码: 506-518
作者:
Li, Chuansheng
;
Shan, Yuanyuan
;
Sun, Ying
;
Si, Ru
;
Liang, Liyuan
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2019/11/26
Hinge-binding group
Anti-angiogenesis agents
Triple inhibitors
Angiogenic RTKs
N-(pyridin-2-yl)acrylamide
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