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大连化学物理研究所 [19]
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Metabolic map of the antiviral drug podophyllotoxin provides insights into hepatotoxicity
期刊论文
XENOBIOTICA, 2021, 页码: 13
作者:
Sun, Dongxue
;
Gao, Xiaoxia
;
Wang, Qiao
;
Krausz, Kristopher W.
;
Fang, Zhongze
收藏
  |  
浏览/下载:49/0
  |  
提交时间:2021/11/04
CYP
podophyllotoxin metabolism
liver microsomes
recombinant drug-metabolizing enzymes
hepatic and intestinal toxicity
The Nonclinical Pharmacokinetics and Prediction of Human Pharmacokinetics of SPH3127, a Novel Direct Renin Inhibitor
期刊论文
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS, 2020, 卷号: 45, 期号: 1, 页码: 15-26
作者:
Zhang, Leduo
;
Mao, Yu
;
Gao, Zhiwei
;
Chen, Xiaoyan
;
Li, Xin
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  |  
浏览/下载:49/0
  |  
提交时间:2020/07/01
Strategy for Hepatotoxicity Prediction Induced by Drug Reactive Metabolites Using Human Liver Microsome and Online 2D-Nano-LC-MS Analysis
期刊论文
ANALYTICAL CHEMISTRY, 2017, 卷号: 89, 期号: 24, 页码: 13167-13175
作者:
Zhuo, Yue
;
Wu, Jian-Lin
;
Yan, Xiaojing
;
Guo, Ming-Quan
;
Liu, Ning
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  |  
浏览/下载:86/0
  |  
提交时间:2017/12/31
Discovery of a widespread metabolic pathway within and among phenolic xenobiotics
期刊论文
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017
Ashrap, Pahriya
;
Zheng, Guomao
;
Wan, Yi
;
Li, Tong
;
Hu, Wenxin
;
Li, Wenjuan
;
Zhang, Hong
;
Zhang, Zhaobin
;
Hu, Jianying
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  |  
浏览/下载:32/0
  |  
提交时间:2017/12/03
triclosan
phenolic xenobiotic
liver microsome
metabolic kinetics
cross-talk reaction
CONSTITUTIVE ANDROSTANE RECEPTOR
REGULATING TRICLOSAN
UNITED-STATES
BISPHENOL-A
METHYL TRICLOSAN
CYTOCHROMES P450
ENZYMES
LIVER
TRICLOCARBAN
INDUCTION
Pharmacokinetics in Vitro and in Vivo of Two Novel Prodrugs of Oleanolic Acid in Rats and Its Hepatoprotective Effects against Liver Injury Induced by CCl4
期刊论文
MOLECULAR PHARMACEUTICS, 2016, 卷号: 13, 期号: 5, 页码: 1699-1710
作者:
Yu, Zongjiang
;
Sun, Weizhi
;
Peng, Weibing
;
Yu, Rilei
;
Li, Guoqiang
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  |  
浏览/下载:28/0
  |  
提交时间:2016/07/12
oleanolic acid (OA)
prodrug
hepatoprotective
pharmacokinetics
biodistribution
Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2016, 卷号: 26, 期号: 6, 页码: 841-850
作者:
Wang, Wenyi
;
Zhu, Hao
;
Yan, Bing
;
Zhang, Yi
;
Wang, Yabin
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  |  
浏览/下载:19/0
  |  
提交时间:2019/06/20
Combinatorial Chemistry
Cyp450
Functionalized Mwcnts
Human Liver Microsome
Pharmacophores
Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2016, 卷号: 26, 期号: 6, 页码: 841-850
作者:
Zhang, Yi
;
Wang, Yabin
;
Liu, Aijuan
;
Xu, Sherry Li
;
Zhao, Bin
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  |  
浏览/下载:13/0
  |  
提交时间:2017/03/27
combinatorial chemistry
CYP450
functionalized MWCNTs
human liver microsome
pharmacophores
Modulation of Carbon Nanotubes' Perturbation to the Metabolic Activity of CYP3A4 in the Liver
期刊论文
ADVANCED FUNCTIONAL MATERIALS, 2016, 卷号: 26, 期号: 6, 页码: 841-850
作者:
Zhang, Yi
;
Wang, Yabin
;
Liu, Aijuan
;
Xu, Sherry Li
;
Zhao, Bin
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2019/12/16
combinatorial chemistry
CYP450
functionalized MWCNTs
human liver
microsome
pharmacophores
Relative contributions of the major human CYP450 to the metabolism of icotinib and its implication in prediction of drug-drug interaction between icotinib and CYP3A4 inhibitors/inducers using physiologically based pharmacokinetic modeling
期刊论文
2015, 卷号: 11, 期号: 6, 页码: 857-868
作者:
Chen, Jia
;
Liu, Dongyang
;
Zheng, Xin
;
Zhao, Qian
;
Jiang, Ji
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2020/01/13
contribution of CYP450s
drug-drug interaction
human liver microsome
icotinib
physiologically based pharmacokinetic
supersome
Herb-drug interaction prediction based on the high specific inhibition of andrographolide derivatives towards UDP-glucuronosyltransferase (UGT) 2B7
期刊论文
toxicology and applied pharmacology, 2014, 卷号: 277, 期号: 1, 页码: 86-94
作者:
Ma, Hai-Ying
;
Sun, Dong-Xue
;
Cao, Yun-Feng
;
Ai, Chun-Zhi
;
Qu, Yan-Qing
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2015/11/17
Andrographolide derivatives
Herb-drug interaction (HDI)
UDP-glucuronosyltransferases (UGTs)
Adverse effects
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